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Toxicity Effects

CAS Registry Number: 346-18-9

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • 2h-1,2,4-Benzothiadiazine-7-Sulfonamide, 6-Chloro-3,4-Dihydro-2-Methyl-3-(((2,2,2-Trifluoroethyl)Thio)Methyl)-, 1,1-Dioxide (9ci)

Human Toxicity Excerpts

  • ...HAS CAUSED ACUTE TRANSITORY MYOPIA IN THIRTY-ONE-YR-OLD WOMAN WHO TOOK DRUG AS DIURETIC SEVERAL MO AFTER NORMAL PREGNANCY IN HOPES OF LOSING WT, & NEXT DAY HAD BLURRED VISION... INTRAOCULAR PRESSURE...SUBNORMAL...[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 754] **PEER REVIEWED**
  • A SINGLE DOSE OF POLYTHIAZIDE UNDER CONDITIONS OF MAXIMAL WATER DIURESIS INCREASED RENAL EXCRETION OF MAGNESIUM.[SOTORNIK I, SCHUCK O; CAS LEK CESK 114(16) 500 (1975)] **PEER REVIEWED**
  • May suppress lactation, but compatible /SRP: with breast feeding/. /Thiazide diuretics, from table/[Young, L.Y., M.A. Koda-Kimble (eds.). Applied Therapeutics. The Clinical Use of Drugs. 6th ed. Vancouver, WA., Applied Therapeutics, Inc. 1995., p. 45-29] **PEER REVIEWED**
  • ONE HUNDRED MOTHERS HAD RECEIVED ORAL DIURETICS FOR AT LEAST 3 WK PRIOR TO ADMISSION & CONTROLS RECEIVED NONE. NO EFFECTS WERE OBSERVED IN PLATELET COUNTS IN EITHER.[JERKNER K, VICTORIN L; ACTA MED SCAND 194: 473 (1973)] **PEER REVIEWED** PubMed Abstract

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Non-Human Toxicity Excerpts

  • ADMIN OF POLYTHIAZIDE 2.5 MG/KG IV TO ANESTHETIZED RATS MARKEDLY DECR THE ATPASE ACTIVITY IN THE KIDNEY CORTEX, BUT NOT IN THE MEDULLA.[TUREK ET AL; PHYSIOL BOHEMOSLOV (1956-65) 18(2) 157 (1969)] **PEER REVIEWED**
  • AFTER 3 CONTROL DAYS, RATS ADMIN 0.1 MG/100 G/DAY OF POLYTHIAZIDE FOR 6 DAYS. IN INTACT RATS HYPOCALCIURIA ASSOC WITH INCR SODIUM EXCRETION & URINE OUTPUT ON TREATMENT DAY 1. IN THYROPARATHYROIDECTOMIZED RATS HYPOCALCIURIA OCCURRED WITHOUT CHANGES IN NA EXCRETION OR BODY WT.[EDWARDS BR, STERN P; NEPHRON 22(4-6) 432 (1978)] **PEER REVIEWED**
  • CHRONIC ADMIN OF 0.1 MG OF POLYTHIAZIDE IV TO RATS INCR LACTATE CONCN IN KIDNEY CORTEX & INCREASED LACTATE & LACTATE DEHYDROGENASE IN THE MEDULLA.[JANATA V, LEGE L; INT Z KLIN PHARMAKOL, THER TOXIKOL 6(2) 125 (1972)] **PEER REVIEWED**
  • IN ACUTE EXPERIMENTS, IP INJECTION OF 0.1 MG OF POLYTHIAZIDE TO RATS INCREASED RENIN ACTIVITY WITHOUT SIGNIFICANTLY CHANGING ERYTHROPOIETIN ACTIVITY.[DONATI RM ET AL; CIRC RES 22(1) 91 (1968)] **PEER REVIEWED**
  • IN RABBITS, POLYTHIAZIDE DEPRESSED URIC ACID URINARY EXCRETION & INCREASED THE BLOOD URIC ACID LEVEL; THE FORMER EFFECT WAS NOT RELATED TO THE DIURETIC EFFECTS OF POLYTHIAZIDE.[MUKHERJEE PK ET AL; INDIAN MED GAZ 15(10) 396 (1976)] **PEER REVIEWED**
  • POLYTHIAZIDE EFFECTED METABOLISM IN RAT KIDNEY.[JANATA V ET AL; CESK FARM 19(MAR) 53 (1970)] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • LD50 Dog oral 450 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2744] **PEER REVIEWED**
  • LD50 Rat ip 400 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2744] **PEER REVIEWED**

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Absorption, Distribution And Excretion

  • IN DOGS...ABOUT 30% OF DRUG IS METABOLIZED & ITS METABOLITES ARE EXCRETED PRIMARILY IN URINE. ABOUT 60 TO 90% OF DRUG & METABOLITE ARE EXCRETED WITHIN 24 HR IN DOG; PRIMARILY IN URINE, BUT UP TO 20% MAY BE EXCRETED IN FECES.[American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 40:28] **PEER REVIEWED**
  • STUDY OF NORMAL HUMAN SUBJECTS RECEIVING SINGLE 1 MG ORAL DOSES REVEALED MEAN PLASMA T/2 FOR ABSORPTION & ELIMINATION OF 1.2 & 25.7 HR, RESPECTIVELY. APPROX 25% OF DRUG WAS EXCRETED UNCHANGED IN THE URINE.[HOBBS DC; CLIN PHARMACOL THER 23(2) 241 (1978)] **PEER REVIEWED**
  • THIAZIDES ARE RAPIDLY ABSORBED FROM GI TRACT... IN GENERAL, THIAZIDES WITH RELATIVELY LONG DURATIONS OF ACTION SHOW...HIGH DEGREES OF BOTH BINDING TO PLASMA PROTEINS & ARE REABSORBED TO GREATER EXTENT BY RENAL TUBULES. ... POLYTHIAZIDE.../HAS/ LONGER DURATION OF ACTION THAT IS CORRELATED WITH SLOWER EXCRETION.[Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 902] **PEER REVIEWED**
  • THIAZIDES CROSS PLACENTA & APPEAR IN CORD BLOOD. /THIAZIDE DIURETICS/[American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 40:28] **PEER REVIEWED**
  • THIAZIDES...APPEAR IN MILK OF NURSING MOTHER. /THIAZIDES/[American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 40:28] **PEER REVIEWED**

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Metabolism/Metabolites

  • YIELDS 5-CHLORO-2-METHYLSULFAMYL-4-SULFAMYLANILINE IN DOG. /FROM TABLE/[Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. 36] **PEER REVIEWED**

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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