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Toxicity Effects

CAS Registry Number: 473-55-2

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • Dihydropinene (9ci)
  • Pinane

Human Toxicity Excerpts

  • None found

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Non-Human Toxicity Excerpts

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Human Toxicity Values

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Non-Human Toxicity Values

  • None found

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Absorption, Distribution And Excretion

  • None found

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Metabolism/Metabolites

  • The biotransformation of (+)-, (-)-, and (+-)-alpha-pinenes, (-)-beta-pinene (nopinene), (-)-cis-pinane, (+)-3-carene, (-)-cis-carane, myrcene, and p-cymene in rabbits was investigated. The major metabolites were as follows: (-)-trans-verbenol from (+)-, (-)-, and (+/-)-alpha-pinenes; (-)-10-pinanol and (-)-1-p-menthene-7,8-diol from (-)-beta-pinene; (-)-alpha-terpineol and (-)-trans-sobrerol from (-)-cis-pinane; (-)-m-mentha-4,6-dien-8-ol, 3-caren-9-ol, (-)-3-carene-9-carboxylic acid, and 3-carene-9,10-dicarboxylic acid from (+)-3-carene; carane-9,10-dicarboxylic acid from (-)-cis-carane; and myrcene-3(10)-glycol, myrcene-1,2-glycol, uroterpenol, and p-cymene-9-carboxylic acid from p-cymene. These metabolisms include allylic oxidation, epoxidation, stereoselective gem-dimethyl hydroxylation and its oxidation, cleavage of a conjugated double bond by epoxidation, and regioselective oxidation, some of which are not found usually in chemical reactions, and due to which various new compounds were determined. This biotransformation of the monoterpene hydrocarbons gave some insect pheromones in high yield.[Ishidata T et al; J Pharm Sci 70 (4): 406-15 (1981) Apr;70(4):406-15] **PEER REVIEWED** PubMed Abstract
  • The major metabolite of pinane was alpha-terpineol and minor metabolites were pinan-2-ol and pinan-3-ol.[ISHIDA T ET AL; TERPENE METABOLITES IN RABBIT URINE. IV. METABOLISM OF PINAN, CARAN, AND MYRCENE; KOEN YOSHISHU- KORYO, TERUPEN OYOBI SEIYU KAGAKU NI KANSURU TORONKAI, 23RD: 39 (1979)] **PEER REVIEWED**

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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