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Toxicity Effects

CAS Registry Number: 504-29-0

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • 2-Pyridinamine (9ci)
  • 2-Pyridylamine
  • O-Aminopyridine

Human Toxicity Excerpts

  • ... CHEM OPERATOR ... MILLING 2-AMINOPYRIDINE WITHOUT PROTECTIVE EQUIPMENT ... DEVELOPED SEVERE POUNDING HEADACHE, NAUSEA, FLUSHING OF EXTREMITIES, & ELEVATED BLOOD PRESSURE, BUT RECOVERED FULLY NEXT DAY. SUBSEQUENT DETERMINATIONS ON THIS OPERATION REVEALED AIR CONCN OF 0.02 MG/L (5.2 PPM).[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 3366] **PEER REVIEWED**
  • ACUTE POISONING CAN OCCUR EITHER FROM INHALATION OF THE DUST OR VAPOR @ RELATIVELY LOW CONCN, OR BY SKIN ABSORPTION FOLLOWING DIRECT CONTACT.[International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1811] **PEER REVIEWED**
  • FATAL INTOXICATION OCCURRED IN A CHEMICAL OPERATOR WHO SPILLED 2-AMINOPYRIDINE DURING DISTILLATION. HE CONTINUED TO WORK IN CONTAMINATED CLOTHING FOR 1 1/2 HR. 2 HR LATER HE DEVELOPED DIZZINESS, HEADACHE, RESP DISTRESS, & CONVULSIONS THAT PROGRESSED TO RESP FAILURE & DEATH.[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 3366] **PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ... TEST APPLICATIONS OF 0.02 M SOLN @ PH 5 TO 7 FOR TEN MIN TO RABBIT EYES FROM WHICH CORNEAL EPITHELIUM HAS BEEN REMOVED PRODUCED RELATIVELY SLIGHT OR NO INJURY WITH ... 2-AMINOPYRIDINE ... .[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 383] **PEER REVIEWED**
  • Aminopyridines: ... cause contraction of skeletal muscle and smooth muscle producing vasoconstriction and increased blood pressure. It has been reported that aminopyridines and some alkyl pyridines exert inotropic and chronotropic action on the heart. /Aminopyridines/[International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1811] **PEER REVIEWED**
  • 2-AMINOPYRIDINE TESTED IN 0.02 M AQ SOLN @ PH 9.4 BY DROPPING FOR 10 MIN ON RABBIT'S CORNEA FROM WHICH EPITHELIUM HAD BEEN REMOVED CAUSED ONLY TRANSIENT CORNEAL HAZE & SLIGHT DELAY IN RETURN TO NORMAL ... .[Grant, W. M. Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974., p. 118] **PEER REVIEWED**
  • 2-Aminopyridine was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using the standard protocol approved by the National Toxicology Program. 2-Aminopyridine was tested at doses of 0, 33, 100, 333, 1000, and 10,000 ug/plate in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. 2-Aminopyridine was negative in these tests and the highest ineffective dose tested in any Salmonella tester strain was 10,000 ug/plate.[Zeiger E et al; Environ Mutagen 9 (9): 1-110 (1987)] **PEER REVIEWED**
  • 2-Aminopyridine was shown to cause a slight, transient eye injury when applied as a 0.02 M aqueous solution (pH > 9.4) on the rabbit cornea. N dermal or eye irritation studies were found.[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 3365] **PEER REVIEWED**
  • IN CHICK NERVE-MUSCLE PREPN & IN FROG SARTORIUS MUSCLE, AMINOPYRIDINES FACILITATE NEUROMUSCULAR TRANSMISSION BY PREJUNCTIONAL ACTION THROUGH WHICH EVOKED & SPONTANEOUS RELEASE OF ACETYLCHOLINE IS INCR.[BOWMAN ET AL; J PHARM PHARMACOL 28(SUPPL) 79 PP (1976)] **PEER REVIEWED**
  • IN RABBIT VAS DEFERENS, RESPONSES TO TRANSMURAL STIMULATION WERE POTENTIATED BY 2-AMINOPYRIDINE.[JOHNS ET AL; EUR J PHARMACOL 38(1): 71-8 (1976)] **PEER REVIEWED** PubMed Abstract
  • IV INJECTION OF 1 MG/KG OF 2-AMINOPYRIDINE IN CATS CAUSES AN INCR IN BLOOD PRESSURE & RESP RATE WITH SYMPTOMS OF CNS STIMULATION & MUSCLE TWITCHING.[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2731] **PEER REVIEWED**
  • LETHAL DOSES IN EXPTL ANIMALS PRODUCE EXCITEMENT WITH TREMORS PROGRESSING TO CONVULSIONS, TETANY, & DEATH. CONVULSIONS OCCUR RAPIDLY & ARE ALMOST ALWAYS FATAL. ... MIN DOSES FOR CONVULSIONS BY IP INJECTION IN MICE ARE 2-AMINOPYRIDINE, 15 MG/KG; 4-AMINOPYRIDINE, 3 MG/KG; AND 3-AMINOPYRIDINE, 10 MG/KG. THE CORRESPONDING IP LD50 IN MICE ARE 35, 9, AND 28 MG/KG. ... AMINO DERIV OF PYRIDINE DO NOT PRODUCE SIGNIFICANT METHEMOGLOBINEMIA IN RATS.[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2731] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • LD50 Guinea pig dermal 500 mg/kg[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 3365] **PEER REVIEWED**
  • LD50 Mouse ip 23 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 193] **PEER REVIEWED**
  • LD50 Mouse ip 35 mg/kg[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2731] **PEER REVIEWED**
  • LD50 Mouse oral 0.05 g/kg[Verschueren, K. Handbook of Environmental Data of Organic Chemicals. 2nd ed. New York, NY: Van Nostrand Reinhold Co., 1983., p. 192] **PEER REVIEWED**
  • LD50 Mouse oral 50 mg/kg[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 3365] **PEER REVIEWED**
  • LD50 Mouse sc 70 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 193] **PEER REVIEWED**
  • LD50 Rat oral 0.2 g/kg[Verschueren, K. Handbook of Environmental Data of Organic Chemicals. 2nd ed. New York, NY: Van Nostrand Reinhold Co., 1983., p. 192] **PEER REVIEWED**
  • LD50 Rat oral 200 mg/kg[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 3365] **PEER REVIEWED**

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Absorption, Distribution And Excretion

  • It may enter the body through the skin.[Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 1] **PEER REVIEWED**
  • MAJORITY OF /PYRIDINE/ DERIVATIVES TESTED ... PENETRATE INTACT GUINEA PIG SKIN READILY. AMINOPYRIDINES, VINYLPYRIDINES & 4-PICOLINE PENETRATE SKIN MOST RAPIDLY & AMYL DERIV & 5-ETHYL-2-METHYLPYRIDINE ARE LEAST READILY ABSORBED. /AMINOPYRIDINES/[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2724] **PEER REVIEWED**
  • PYRIDINE & ITS ALKYL DERIVATIVES ARE ABSORBED FROM GI TRACT, INTRAPERITONEAL CAVITY & LUNGS. PERITONEAL ABSORPTION IS APPARENTLY ONLY SLIGHTLY MORE RAPID & COMPLETE THAN GI ABSORPTION... IN GENERAL THE BASES ARE RAPIDLY ABSORBED THROUGH INTACT SKIN. /ALKYL DERIVATIVES OF PYRIDINE/[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2719] **PEER REVIEWED**

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Metabolism/Metabolites

  • Rats were fed 100 or 1000 ppm methapyrilene in their diet for 1, 2, 4, 8 or 16 weeks. Liver microsomes were prepared from both control and treated rats. After incubation with 1 mM methapyrilene, eight metabolites were detected and six were quantitated. /One/ ... metabolites /was/ identified as ... 2-aminopyridine. ...[Lampe MA, Kammerer RC; Carcinogenesis 8 (2): 221-6 (1987)] **PEER REVIEWED** PubMed Abstract

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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