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Toxicity Effects

CAS Registry Number: 9004-67-5

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • 0.5% Methylcellulose

Human Toxicity Excerpts

  • ...TABLETS OF METHYLCELLULOSE HAVE CAUSED FECAL IMPACTION & INTESTINAL OBSTRUCTION WHEN TAKEN WITH LIMITED AMT OF WATER.[Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1244] **PEER REVIEWED**
  • THIS AGENT IS NONIRRITATING TO OCULAR TISSUE & CAN BE USED FOR PROLONGED PERIODS WITHOUT CAUSING DAMAGE TO EYE. IT MAY CAUSE DISCOMFORT IF EXCESS SOLN IS ALLOWED TO DRY ON UPPER LID.[American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 992] **PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ...WHEN...INJECTED INTO RAT IT ULTIMATELY GIVES RISE TO CARDIOVASCULAR TROUBLES...[Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 282] **PEER REVIEWED**
  • Researchers: repeatedly admin low viscosity (15 cP) methyl cellulose intravenously to dogs and observed serious effects characterized by a progressive decrease in the volume of urine and the presence in the urine of albumin, casts, and both red and white blood cells. Nonprotein nitrogen levels of blood rose sharply but blood pressure was not increased.[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 511] **PEER REVIEWED**
  • BULK FILLERS (EG, METHYLCELLULOSE) HAVE BEEN SHOWN IN ANIMALS TO HAVE ONLY TRANSIENT ANORECTIC EFFECT.[American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 487] **PEER REVIEWED**
  • GIVEN PARENTERALLY, HOWEVER, METHYL CELLULOSE PRODUCES GLOMERULONEPHRITIS & HYPERTENSION IN RATS.[Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-167] **PEER REVIEWED**
  • Groups of rats were injected ip with methyl cellulose (400 cP) twice weekly for 15 weeks. Animals observations were made of grossly enlarged spleens, changes in the bone marrow and cellular elements of the blood, ascites, and infiltration of the spleen, liver, and kidneys with "storage-cell" macrophages.[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 511] **PEER REVIEWED**
  • Injected into the anterior chamber of rabbits, 0.1 ml of 0.5-1% methyl cellulose in 0.9% sodium chloride soln causes mild iridocyclitis ... in balanced salt soln ... causes no clinically evident reaction. ... when AQ humor is replaced by 0.5% methyl cellulose in rabbit intraocular pressure may rise to 60 mm Hg during next hr or 2.[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 611] **PEER REVIEWED**
  • Low viscosity (15 cP) methylcellulose /admin/ iv to dogs produced serious ... necrotizing vascular disease was frequently observed and death was generally due to renal failure.[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 511] **PEER REVIEWED**
  • METHYL CELLULOSE IS ARTIFICIAL HIGH POLYMER & IV INJECTIONS OF IT HAVE BEEN TRIED OUT ON DOGS... IT WAS SHOWN THAT REPEATED SMALL DOSES GAVE RISE TO KIDNEY LESIONS SIMILAR TO THOSE FOUND IN GLOMERULAR NEPHRITIS. ...CANNOT BE USED AS PLASMA SUBSTITUTE.[Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 282] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • LD50 Mouse ip 275 g/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2206] **PEER REVIEWED**

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Absorption, Distribution And Excretion

  • ... Reported that when methylcellulose was given iv to dog and rabbit ... aside from effect upon circulating blood, inability of body to degrade substance led to its retention & accumulation in liver, spleen, lymph nodes, kidney, and vascular walls.[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 511] **PEER REVIEWED**
  • When swallowed they are not absorbed to any appreciable degree and appear unchanged in feces. /Cellulose ethers/[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 510] **PEER REVIEWED**

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Metabolism/Metabolites

  • None found

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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