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Toxicity Effects

CAS Registry Number: 926-06-7

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • Isopropyl methanesulfonate

Human Toxicity Excerpts

  • None found

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Non-Human Toxicity Excerpts

  • GENOTOXICITY: ... Isopropyl methanesulfonate ... /induces dominant lethal mutations/ in meiotic and premeiotic sperm /of mice and rats/.[Searle, C. E. (ed.). Chemical Carcinogens. ACS Monograph 173. Washington, DC: American Chemical Society, 1976., p. 127] **PEER REVIEWED**
  • GENOTOXICITY: Storage of isopropylmethanesulfonate-treated seeds at 30% water content resulted in recovery from induced mutagenic effects, while at 5% seed water content no significant changes in frequency of chromosome aberrations or in frequency of m2 chlorophyll mutants were detected.[Gichner T, Veleminsky J; Mutat Res 16 (1): 35 (1972)] **PEER REVIEWED**
  • LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity: Isopropyl methanesulfonate, a direct-acting SN1 alkylating agent, induced thymic lymphomas in 29 of 30 female Hsd: (ICR)BR mice by the 139th day following once a week subcutaneous injections at a dose of 10 umol/mouse. No such neoplasms were observed at the 450th day following 52 once a week subcutaneous injections (20 umol/mouse) of the borderline SN1/SN2 alkylating agent ethyl methanesulfonate. Local sarcomas were observed in 2 and pulmonary adenomas in 20 of the 30 ethyl methanesulfonate treated mice, 70% of which were alive at the 450th day. Neoplasms were not observed at local or at distant sites other than the thymus gland following treatment with isopropyl methanesulfonate.[Segal A, Sellakumar A; Cancer Lett 44 (3): 199-204 (1989)] **PEER REVIEWED** PubMed Abstract
  • LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity: Six-wk-old female HSD:(ICR)BR mice were divided into three groups: 1) vehicle control (30 mice), 2) untreated control (60 mice), and 3) isopropyl methanesulfonate treated (32 mice). Group 1 received 0.05 mL trioctanoin subcutaneously once per week for 288 days, group 2 received no treatment, and group 3 received all injections of IMS in 0.05 mL trioctanoin once per week subcutaneously. The dose of isopropyl methanesulfonate was 2.8 mg (20 micromoles) for 63 days, 1.4 mg (10 micromoles) for the next 57 days, and then 0.7 mg (5 micromoles) for the final 82 days of treatment. Animals were necropsied when moribund. None of the group 1 or group 2 animals had died by day 288, when the report was written. By 63 days, 2 of 7 moribund animals in group 3 had lymphoid neoplasms (therefore the dose was halved); from 63 to 120 days, 10 of 15 treated mice had lymphoid neoplasms (again the dose was halved); and the remainder of the animals in group 3 were moribund by 202 days. Of group 3, 5 animals died with no evidence of neoplasia and 7 animals were too autolysed to autopsy. The mean survival time of tumor bearing animals was 118 days after initiation of treatment. Altogether 20 of 32 treated mice (group 3) developed lymphoid neoplasms of thymus origin.[Segal A et al; Proc Soc Exp Biol Med 183: 132-5 (1986)] **PEER REVIEWED** PubMed Abstract
  • LABORATORY ANIMALS: Developmental or Reproductive Toxicity: Decreased fertility in female mice following single ip injection of isopropyl methanesulfonate has been observed ...[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2093] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • None found

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Absorption, Distribution And Excretion

  • None found

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Metabolism/Metabolites

  • ... Isopropyl methanesulfonate ... in rat was found to yield isopropanol and methanesulfonic acid.[Testa, B. and P. Jenner. Drug Metabolism: Chemical & Biochemical Aspects. New York: Marcel Dekker, Inc., 1976., p. 141] **PEER REVIEWED**
  • ... Low quantities of 75 mg/kg were promptly metabolized producing urinary metabolites, S-isopropylcysteine and S-isopropylcysteine N-acetate, accounting for 30% of the administered dose.[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2093] **PEER REVIEWED**

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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