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TOX-99: Toxicity Report Tables & Curves

Pathology Tables, Survival and Growth Curves from NTP
Short-Term, Immunotoxicology, In Vitro Activity (Human), and Micronucleus Studies

https://doi.org/10.22427/NTP-DATA-TOX-99

TOX-99: Gum Guggul Extract

Short-Term

28-Day Interim Study Tables - Rats

E03 - Growth Curves (369KB)
E04 - Mean Body Weights and Survival Table (12KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (21KB)
P04 - Neoplasms by Individual Animal (146KB)
P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (22KB)
P08 - Statistical Analysis of Primary Tumors (7KB)
P09 - Non-Neoplastic Lesions by Individual Animal (138KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (59KB)
P14 - Individual Animal Pathology Data (163KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (21KB)
P40 - Survival Curves (395KB)
PA06 - Organ Weights Summary (153KB)
PA41 - Clinical Chemistry Summary (508KB)
PA43 - Hematology Summary (582KB)
PA49 - Cytochrome Activity Summary (78KB)
R07 - Hormone Summary (102KB)

28-Day Individual Animal Data - Rats

Female Individual Animal BodyWeight (18KB)
Female Individual Animal Non Neoplastic Pathology Data (12KB)
Female Individual Animal Survival Data (11KB)
Female Individual Animal Terminal Body Weight Data (19KB)
Male Individual Animal Body Weight Data (18KB)
Male Individual Animal Non Neoplastic Pathology Data (10KB)
Male Individual Animal Survival Data (11KB)
Male Individual Animal Terminal Body Weight Data (19KB)
Individual Animal Clinical Chemistry Data (24KB)
Individual Animal Cytochrome Activity Data (14KB)
Individual Animal Hematology Data (32KB)
Individual Animal Hormone Data (14KB)
Individual Animal Organ Weight Data (20KB)

28-Day Interim Study Tables - Mice

E03 - Growth Curves (406KB)
E04 - Mean Body Weights and Survival Table (13KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (19KB)
P04 - Neoplasms by Individual Animal (138KB)
P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (23KB)
P08 - Statistical Analysis of Primary Tumors (8KB)
P09 - Non-Neoplastic Lesions by Individual Animal (74KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (24KB)
P14 - Individual Animal Pathology Data (155KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (20KB)
P40 - Survival Curves (390KB)
PA06 - Organ Weights Summary (152KB)
PA41 - Clinical Chemistry Summary (174KB)
PA49 - Cytochrome Activity Summary (78KB)

28-Day Individual Animal Data - Mice

Female Individual Animal Body Weight Data (18KB)
Female Individual Animal Neoplastic Pathology Data (2KB)
Female Individual Animal Non Neoplastic Pathology Data (2KB)
Female Individual Animal Survival Data (11KB)
Female Individual Animal Terminal Body Weight Data (19KB)
Male Individual Animal Body Weight Data (18KB)
Male Individual Animal Non Neoplastic Pathology Data (3KB)
Male Individual Animal Survival Data (11KB)
Male Individual Animal Terminal Body Weight Data (19KB)
Individual Animal Clinical Chemistry Data (17KB)
Individual Animal Cytochrome Activity Data (9KB)
Individual Animal Organ Weight Data (15KB)

3-Month Study Tables - Rats

E03 - Growth Curves (455KB)
E04 - Mean Body Weights and Survival Table (18KB)
E05 - Clinical Observations Summary (14KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (34KB)
P04 - Neoplasms by Individual Animal (231KB)
P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (34KB)
P09 - Non-Neoplastic Lesions by Individual Animal (237KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (191KB)
P14 - Individual Animal Pathology Data (265KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (35KB)
P40 - Survival Curves (435KB)
PA06 -Organ Weights Summary (153KB)
PA41 -Clinical Chemistry Summary (508KB)
PA43 -Hematology Summary (582KB)
PA49 -Cytochrome Activity Summary (78KB)
R06 -Andrology Summary (51KB)
R07 -Hormone Summary (102KB)

3-Month Individual Animal Data - Rats

Female Individual Animal Body Weight Data (35KB)
Female Individual Animal Neoplastic Pathology Data (2KB)
Female Individual Animal Non Neoplastic Pathology Data (27KB)
Female Individual Animal Survival Data (11KB)
Female Individual Animal Terminal Body Weight Data (19KB)
Female Individual Clinical Observations (2KB)
Male Individual Animal Body Weight Data (35KB)
Male Individual Animal Non Neoplastic Pathology Data (27KB)
Male Individual Animal Survival Data (11KB)
Male Individual Animal TerminalBody Weight Data (19KB)
Male Individual Clinical Observations (2KB)
Individual Animal Andrology Data (8KB)
Individual Animal Clinical Chemistry Data (24KB)
Individual Animal Cytochrome Activity Data (14KB)
Individual Animal Hematology Data (32KB)
Individual Animal Hormone Data (14KB)
Individual Animal Organ Weight Data (20KB)

3-Month Study Tables - Mice

E03 - Growth Curves (419KB)
E04 - Mean Body Weights and Survival Table (18KB)
E05 - Clinical Observations Summary (14KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (28KB)
P04 - Neoplasms by Individual Animal (193KB)
P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (34KB)
P09 - Non-Neoplastic Lesions by Individual Animal (125KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (48KB)
P14 - Individual Animal Pathology Data (364KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (29KB)
P40 - Survival Curves (433KB)
PA06-Organ Weights Summary (152KB)
PA41-Clinical Chemistry Summary (174KB)
PA49-Cytochrome Activity Summary (78KB)
R06 Andrology Summary (51KB)

3-Month Individual Animal Data - Mice

Female Individual Animal Body Weight Data (50KB)
Female Individual Animal Neoplastic Pathology Data (2KB)
Female Individual Animal Non Neoplastic Pathology Data (8KB)
Female Individual Animal Survival Data (16KB)
Female Individual Animal Terminal Body Weight Data (27KB)
Male Individual Animal Body Weight Data (50KB)
Male Individual Animal Non Neoplastic Pathology Data (5KB)
Male Individual Animal Survival Data (16KB)
Male Individual Animal TerminalBody Weight Data (27KB)
Male Individual Clinical Observations (2KB)
Individual Animal Andrology Data (8KB)
Individual Animal Clinical Chemistry Data (17KB)
Individual Animal Cytochrome Activity Data (9KB)
Individual Animal Organ Weight Data (15KB)

Immunotoxicology

4-Week Immunotoxicity Study Tables

E03 - Growth Curves (181KB)
E04 - Mean Body Weights and Survival Table (15KB)
E05 - Clinical Observations Summary (11KB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (22KB)
P04 - Neoplasms by Individual Animal (121KB)
P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (22KB)
P09 - Non-Neoplastic Lesions by Individual Animal (127KB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (87KB)
P14 - Individual Animal Pathology Data (121KB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (23KB)
P40 - Survival Curves (209KB)

4-Week Immunotoxicity Individual Animal Data

Female Individual Animal Body Weight Data (12KB)
Female Individual Animal Non Neoplastic Pathology Data (19KB)
Female Individual Animal Survival Data (11KB)
Female Individual Animal Terminal Body Weight Data (18KB)
Individual Animal ANTI-CD3 Proliferation Data (20KB)
Individual Animal Body Weight Data (106KB)
Individual Animal Gross Observations Data (61KB)
Individual Animal Hematology Data (22KB)
Individual Animal Histo Pathology Data (9KB)
Individual Animal In Vitro Cytotoxic T Lymphocyte Data (30KB)
Individual Animal Leukocyte Cell Differential Data (9KB)
Individual Animal Mixed Leukocyte Response Data (23KB)
Individual Animal Mononuclear Phagocytic System Data (36KB)
Individual Animal Natural Killer Cell Activity Data (23KB)
Individual Animal Organ Weight Data (36KB)
Individual Animal Periodic Weight Gain Data (93KB)
Individual Animal Reticulocytes Data (7KB)
Individual Animal Serum Anti-KLH ELISA Data (7KB)
Individual Animal Serum IgM Data (18KB)
Individual Animal Surface Markers Absolute Data (22KB)
Individual Animal Surface Markers Percentage Data (22KB)
Individual Animal T-Dependent Antibody Response Data (21KB)

In Vitro Activity (Human)

Micronucleus