DART-08: Developmental and Reproductive Toxicity
Growth and Clinical Finding Tables (I), Pathology Tables (PA), Developmental and Reproductive Tables (R) from NTP Modified One Generation Dose Range Finding Study and Modified One Generation Main Study Studies
Pup Body Weight tables (R19/R19G/R19C) were added on September 4, 2020.
Analysis for Gross Pathology table (PA46R) was updated on 14Aug2020. The following tables were updated on November 4, 2020 for clarity in presentation and statistical updates: I04G, I06, R09, R10, R19, R19C and R19G. Gross Pathology table (PA46R) was replaced on November 9, 2020 with additional analysis included.
The R03 report for the Main Study was replaced on January 7,2021.
The following tables were replaced for the Main study on February 3, 2021 due to reanalysis of data: I03, I03C, I04, I04G, and PA06. The Dose range finding study tables (I06 and I08) were reanalyzed and replaced on February 3, 2021.
Note:The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.