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ADME/TK Evaluation (K20239) of 2-Ethylhexyl p-Methoxycinnamate (5466-77-3) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration, Intravenous Injection or Dermal Application

Radiolabel Description:
Carbon-14; 2-Ethylhexyl p-Methoxycinnamate [ring-1-14C, ethylhexyl-1-14C]-

Intravenous, Cremophor:saline:ethanol (20:70:10); Oral, Cremophor; Dermal, olive oil:emulsifying wax: water (15:15:70 v/w/v) (lotion) or ethanol or acetone.

Fennell TR, Mathews JM, Snyder RW, Hong Y, Watson SL, Black SR, McIntyre BS, Waidyanatha S.
Metabolism and disposition of 2-ethylhexyl-p-methoxycinnamate following oral gavage and dermal exposure in Harlan Sprague Dawley rats and B6C3F1/N mice and in hepatocytes in vitro.
Xenobiotica. 2018 Nov;48(11):1142-1156. doi: href=" Epub 2017 Nov 23. PMID: 29111853

Summary Data - Male Rats

Summary Data - Female Rats

Summary Data - Male Mice

Summary Data - Female Mice