ADME/TK Evaluation (K20239) of 2-Ethylhexyl p-Methoxycinnamate (5466-77-3) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration, Intravenous Injection or Dermal Application

Radiolabel Description:
Carbon-14; 2-Ethylhexyl p-Methoxycinnamate [ring-1-¹⁴C, ethylhexyl-1-¹⁴C]-

Vehicles:
Intravenous, Cremophor:saline:ethanol (20:70:10); Oral, Cremophor; Dermal, olive oil:emulsifying wax: water (15:15:70 v/w/v) (lotion) or ethanol or acetone.

Fennell TR, Mathews JM, Snyder RW, Hong Y, Watson SL, Black SR, McIntyre BS, Waidyanatha S.
Metabolism and disposition of 2-ethylhexyl-p-methoxycinnamate following oral gavage and dermal exposure in Harlan Sprague Dawley rats and B6C3F1/N mice and in hepatocytes in vitro.
Xenobiotica. 2018 Nov;48(11):1142-1156. doi: href="https://doi.org/10.1080/00498254.2017.1400129. Epub 2017 Nov 23. PMID: 29111853

Summary Data - Male Rats

• Dermal Single Dose (8 mg/kg in Ethanol, Study Duration 72 hours) (69KB)
• Dermal Single Dose (8 mg/kg in Lotion, Study Duration 72 hours) (67KB)
• Gavage Single Dose (8 mg/kg, Study Duration 24 hours) (50KB)
• Gavage Single Dose (8 mg/kg, Study Duration 72 hours) (52KB)
• Gavage Single Dose (80 mg/kg, Study Duration 72 hours) (52KB)
• Gavage Single Dose (800 mg/kg, Study Duration 72 hours) (78KB)
• IV Single Dose (8 mg/kg, Study Duration 24 hours) (53KB)

Summary Data - Female Rats

• Dermal Single Dose (8 mg/kg in Ethanol, Study Duration 72 hours) (69KB)
• Gavage Single Dose (8 mg/kg, Study Duration 72 hours) (54KB)
• IV Single Dose (8 mg/kg, Study Duration 24 hours) (70KB)

Summary Data - Male Mice

• Dermal Single Dose (0.8 mg/kg in Ethanol, Study Duration 72 hours) (101KB)
• Dermal Single Dose (8 mg/kg Uncovered, Study Duration 72 hours) (95KB)
• Dermal Single Dose (8 mg/kg in Ethanol, Study Duration 72 hours) (65KB)
• Dermal Single Dose (80 mg/kg in Acetone, Study Duration 72 hours) (85KB)
• Dermal Single Dose (80 mg/kg in Ethanol, Study Duration 72 hours) (110KB)
• Gavage Single Dose (8 mg/kg, Study Duration 72 hours) (63KB)
• IV Single Dose (8 mg/kg, Study Duration 72 hours) (73KB)

Summary Data - Female Mice

• Dermal Single Dose (8 mg/kg in Ethanol, Study Duration 72 hours) (67KB)
• Gavage Single Dose (8 mg/kg, Study Duration 72 hours) (72KB)
• IV Single Dose (8 mg/kg, Study Duration 72 hours) (89KB)