ADME/TK Evaluation (K88007) of Butyl Paraben (94-26-8) in Harlan Sprague-Dawley Rats Exposed via Gavage Administration, Intravenous Injection or Dermal Application
Radiolabel Description:
Carbon-14 uniformly in the ring; Butyl Paraben [Phenyl ring-14C(U)]-
Vehicles:
Intravenous, propylene glycol:0.9% saline:ethanol (60:30:10, v:v:v); Oral, Cremophor; Dermal, 95% ethanol.
Mathews JM, Brown SS, Patel PR, Black SR, Banks TT, Etheridge AS, Fennell TR, Snyder RW, Blystone CR, Waidyanatha S.
Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application.
Xenobiotica. 2013 Feb;43(2):169-81. doi: https://doi.org/10.3109/00498254.2012.702935. Epub 2012 Jul 25. PMID: 22830980
Summary Data - Male Rats
- Dermal Single Dose (10 mg/kg, Study Duration 72 hours) (53KB)
- Dermal Single Dose (100 mg/kg, Study Duration 24 hours) (167KB)
- Dermal Single Dose (100 mg/kg, Study Duration 72 hours) (59KB)
- Gavage Single Dose (10 mg/kg, Study Duration 72 hours) (50KB)
- Gavage Single Dose (100 mg/kg, Study Duration 24 hours) (47KB)
- Gavage Single Dose (100 mg/kg, Study Duration 72 hours) (57KB)
- Gavage Single Dose (1000 mg/kg, Study Duration 2 hours) (41KB)
- Gavage Single Dose (1000 mg/kg, Study Duration 72 hours) (58KB)
- IV Single Dose (10 mg/kg, Study Duration 24 hours) (51KB)
- IV Single Dose (10 mg/kg, Study Duration 72 hours) (50KB)