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ADME/TK Evaluation (K88007) of Butyl Paraben (94-26-8) in Harlan Sprague-Dawley Rats Exposed via Gavage Administration, Intravenous Injection or Dermal Application

Radiolabel Description:
Carbon-14 uniformly in the ring; Butyl Paraben [Phenyl ring-14C(U)]-

Intravenous, propylene glycol:0.9% saline:ethanol (60:30:10, v:v:v); Oral, Cremophor; Dermal, 95% ethanol.

Mathews JM, Brown SS, Patel PR, Black SR, Banks TT, Etheridge AS, Fennell TR, Snyder RW, Blystone CR, Waidyanatha S.
Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application.
Xenobiotica. 2013 Feb;43(2):169-81. doi: Epub 2012 Jul 25. PMID: 22830980

Summary Data - Male Rats

Summary Data - Female Rats