ADME/TK Evaluation (S0829) of 1-Bromopropane (106-94-5) in F344 Rats and B6C3F1 Mice Exposed via Intravenous Injection or Dermal Application

Radiolabel Description:
Carbon-14 in the C-1 position, 1-Bromopropane, [1-¹⁴C]; Study I [¹³C, ¹⁴C]1-Bromopropane carbon-13 in the C-3 position, 1-Bromopropane [3-¹³C] 20 mg/kg combined with [¹⁴C]1-Bromopropane 0.8 mg/kg Carbon-14 in the C-1 position.

Vehicles:
Intravenous, 0.9% saline and 5% alkamuls; Dermal, ethanol.

Summary Data - Male Rats

• Dermal Single Dose (100 mg/kg, Study Duration 48 hours) (45KB)
• IV 3 min Infusion (20 mg/kg, Study Duration 48 hours, high radioactivity) (35KB)
• IV 3 min Infusion (20 mg/kg, Study Duration 48 hours, low radioactivity) (35KB)
• IV 3 min Infusion (5 mg/kg, Study Duration 48 hours) (35KB)
• IV Single Bolus Dose (100 mg/kg, Study Duration 48 hours) (37KB)
• IV Single Bolus Dose (20 mg/kg & Pretreat, Study Duration 48 hours) (66KB)
• IV Single Bolus Dose (20 mg/kg, Study Duration 48 hours, bolus injection) (38KB)
• IV Single Bolus Dose (5 mg/kg, Study Duration 48 hours, bolus injection) (38KB)
• IV Toxicokinetics for Male Rats (115KB)
• Individual Animal Data (Toxicokinetics) (14KB)

Summary Data - Male Mice

• IV Single Dose (100 mg/kg, Study Duration 48 hours) (38KB)
• IV Single Dose (20 mg/kg, Study Duration 48 hours) (47KB)
• IV Single Dose (5 mg/kg, Study Duration 48 hours) (56KB)

Summary Data - Rats and Mice

• IV Single Bolus Dose (5, 20, & 100 mg/kg, Study Duration 48 hours) (24KB)