ADME/TK Evaluation (S0840) of Androstenedione (63-05-8) in F344 Rats, B6C3F1 Mice and Beagle Dogs Exposed via Gavage Administration, Intravenous Injection or Dermal Application

Radiolabel Description:
Carbon-14; Androst-4-ene-3,17-dione, [4-¹⁴C]-

Vehicles:
Intravenous, ethanol: PEG300: saline (8.6:45.7:45.7); Oral, 0.5% methyl cellulose; Dermal, 50% ethanol:50% propylene glycol.

Summary Data - Rats

• Dermal or Gavage Single Dose (1, 10, or 100 mg/kg, Study Duration 24 hours) (46KB)
• Gavage Single Dose (1, 10, or 100 mg/kg, Study Duration 72 hours) (53KB)

Summary Data - Mice

• Gavage Single Dose (1, 10, or 100 mg/kg, Study Duration 72 hours) (53KB)

Summary Data - Beagle Dogs

• Gavage Single Dose (1 mg/kg, Study Duration 120 hours) (36KB)
• Gavage Single Dose (100 mg/kg, Study Duration 120 hours) (36KB)
• IV Single Dose (1 mg/kg, Study Duration 120 hours) (38KB)

Summary and Individual Data – Toxicokinetics

• Gavage, IV, and Dermal Toxicokinetics for Male and Female Rats and Dogs (333KB)
• Individual Animal Data (Toxicokinetics) (21KB)