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ADME/TK Evaluation (S0876) of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super®; OTNE) (54464-57-2) in F344 Rats Exposed via Gavage Administration or Dermal Application

Radiolabel Description:
Carbon-14 in the C-8 position as shown by the manufacturer structure; Iso E Super, [8-14C]- (> 95% 1a-beta isomer)

Oral, 0.9% saline:Alkamuls (9:1); Dermal, 100% ethanol.

Waidyanatha S, Ryan K.
Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application.
Xenobiotica. 2014 Aug;44(8):749-56. doi: Epub 2014 Feb 17. PMID: 24533629

Summary Data - Male Rats