ADME/TK Evaluation (S0876) of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super®; OTNE) (54464-57-2) in F344 Rats Exposed via Gavage Administration or Dermal Application
Radiolabel Description:
Carbon-14 in the C-8 position as shown by the manufacturer structure; Iso E Super, [8-14C]- (> 95% 1a-beta isomer)
Vehicles:
Oral, 0.9% saline:Alkamuls (9:1); Dermal, 100% ethanol.
Waidyanatha S, Ryan K.
Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application.
Xenobiotica. 2014 Aug;44(8):749-56. doi: https://doi.org/10.3109/00498254.2014.888489. Epub 2014 Feb 17. PMID: 24533629
Summary Data - Male Rats
- Dermal Single Dose (55 mg/kg Covered, Study Duration 24 hours) (50KB)
- Dermal Single Dose (55 mg/kg Covered, Study Duration 48 hours) (69KB)
- Dermal Single Dose (55 mg/kg Covered, Study Duration 96 hours) (50KB)
- Dermal Single Dose (55 mg/kg Uncovered, Study Duration 24 hours) (50KB)
- Dermal Single Dose (55 mg/kg Uncovered, Study Duration 24 hours, Reduced Air Flow) (35KB)
- Dermal Single Dose (55 mg/kg Uncovered, Study Duration 48 hours) (50KB)
- Dermal Single Dose (55 mg/kg Uncovered, Study Duration 96 hours) (50KB)
- Dermal Single Dose (550 mg/kg Covered, Study Duration 24 hours) (50KB)
- Dermal Single Dose (550 mg/kg Covered, Study Duration 48 hours) (51KB)
- Dermal Single Dose (550 mg/kg Covered, Study Duration 96 hours) (50KB)
- Dermal Single Dose (550 mg/kg Uncovered, Study Duration 24 hours) (51KB)
- Dermal Single Dose (550 mg/kg Uncovered, Study Duration 48 hours) (51KB)
- Dermal Single Dose (550 mg/kg Uncovered, Study Duration 96 hours) (50KB)
- Gavage Single Dose (20 mg/kg, Excreta with Bile, Study Duration 48 hours) (68KB)
- Gavage Single Dose (20 mg/kg, Study Duration 24 hours) (95KB)
- Gavage Single Dose (20 mg/kg, Study Duration 4 hours) (93KB)
- Gavage Single Dose (20 mg/kg, Study Duration 48 hours) (76KB)
- Gavage Single Dose (20 mg/kg, Study Duration 8 hours) (94KB)
- Gavage and Dermal Toxicokinetics for Male Rats (284KB)
- Individual Animal Data (Toxicokinetics) (106KB)