ADME/TK Evaluation (S0930) of Ionic Liquid (1-Butyl-3-methylimidazolium chloride) (79917-90-1) in F344 Rats Exposed via Gavage Administration, Intravenous Injection or Dermal Application
Radiolabel Description:
Carbon-14; N-[1-14C]Butyl-3methylimidazolium chloride
Vehicles:
Intravenous, not specified; Oral, 0.9% Sodium chloride; Dermal, Nanopure water or ethanol:water (63.7:37.3) or Dimethylformamide:water (63.7:37.3).
Summary Data - Male Rats
- Dermal Single Dose (5 mg/kg in DMF, Study Duration 48 hours) (41KB)
- Dermal Single Dose (5 mg/kg in Ethanol, Study Duration 48 hours) (40KB)
- Dermal Single Dose (5 mg/kg in Nanopure Water, Study Duration 72 hours) (43KB)
- Gavage Multiple Dose 5-Day (50 mg/kg, Study Duration 24 hours) (54KB)
- Gavage Single Dose (0.5, 5, and 50 mg/kg, Study Duration 72 hours) (39KB)
- Gavage Single Dose (50 mg/kg, Study Duration 24 hours) (36KB)
- Gavage and IV Toxicokinetics for Male Rats (352KB)
- IV Single Dose (5 mg/kg, Study Duration 48 hours) (32KB)