ADME/TK Evaluation (S0977) of 2,2-Bis(bromomethyl)-1,3-propanediol (329-6-90-0) in F344 Rats and B6C3F1 Mice Exposed via Gavage Administration or Intravenous Injection
Radiolabel Description:
Carbon-14 positions C-1 and C-2; (S)-2-Amino-3-(methylamino)propionic acid hydrochloride, [propionyl-1,2-14C]-
Vehicles:
Intravenous, ethanol: water: Cremophore EL 1:1:3 (v:v:v); Oral, ethanol:water:Cremophore EL 1:1:3 (v:v:v).
Summary Data - Male Rats
- Gavage Multiple Dose 1, 5 or 10-Day (100 mg/kg, Study Duration 24 hours) (43KB)
- Gavage Single Dose (10 mg/kg, Study Duration 72 hours) (27KB)
- Gavage Single Dose (100 mg/kg, Study Duration 72 hours) (65KB)
- IV Single Dose (10 mg/kg, Study Duration 72 hours) (146KB)
- IV Toxicokinetics for Male Rats (123KB)