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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: beta-Picoline
CASRN: ="108-99-6"
Study Number: C20009
Exposure Route: DOSED WATER
TDMS Number: 2000904
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
201 Vehicle Control Eye Abnormality 07/17/2006 11/08/04 617.00 No
201 Vehicle Control Eye Abnormality 08/14/2006 11/08/04 645.00 No
201 Vehicle Control Eye Abnormality 09/11/2006 11/08/04 673.00 No
201 Vehicle Control Eye Abnormality 10/09/2006 11/08/04 701.00 No
201 Vehicle Control Eye Abnormality 11/08/2006 11/08/04 731.00 Yes
202 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 10/09/2006 11/08/04 701.00 No
202 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 11/08/2006 11/08/04 731.00 Yes
204 Vehicle Control Thin 09/18/2006 11/08/04 680.00 Yes
204 Vehicle Control Paralysis 09/18/2006 11/08/04 680.00 Yes
204 Vehicle Control Abnormal Breathing 09/18/2006 11/08/04 680.00 Yes
204 Vehicle Control Lethargic 09/18/2006 11/08/04 680.00 Yes
207 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 10/06/2006 11/08/04 698.00 Yes
208 Vehicle Control Mass Torso/Lateral, Medium (6mm-15mm) 1 09/11/2006 11/08/04 673.00 No
208 Vehicle Control Mass Torso/Lateral, Medium (6mm-15mm) 1 10/09/2006 11/08/04 701.00 No
208 Vehicle Control Mass Torso/Lateral, Medium (6mm-15mm) 1 11/08/2006 11/08/04 731.00 Yes
212 Vehicle Control Ulcer/Abscess Appendage 1 11/03/2006 11/08/04 726.00 Yes
219 Vehicle Control Eye Abnormality 08/14/2006 11/08/04 645.00 No
219 Vehicle Control Mass Head, Medium (6mm-15mm) 1 09/06/2006 11/08/04 668.00 Yes
219 Vehicle Control Eye Abnormality 09/06/2006 11/08/04 668.00 Yes
223 Vehicle Control Thin 09/07/2006 11/08/04 669.00 Yes
223 Vehicle Control Abnormal Breathing 09/07/2006 11/08/04 669.00 Yes
223 Vehicle Control Ruffled Fur 09/07/2006 11/08/04 669.00 Yes
223 Vehicle Control Lethargic 09/07/2006 11/08/04 669.00 Yes
232 Vehicle Control Mass Head, Small (1mm-5mm) 1 09/11/2006 11/08/04 673.00 No
232 Vehicle Control Mass Head, Small (1mm-5mm) 1 10/09/2006 11/08/04 701.00 No
232 Vehicle Control Mass Head, Small (1mm-5mm) 1 11/06/2006 11/08/04 729.00 Yes
238 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 06/19/2006 11/08/04 589.00 No
238 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 07/17/2006 11/08/04 617.00 No
238 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 08/14/2006 11/08/04 645.00 No
238 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 09/11/2006 11/08/04 673.00 No
238 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 10/09/2006 11/08/04 701.00 No
238 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 11/08/2006 11/08/04 731.00 Yes
245 Vehicle Control Ruffled Fur 06/19/2006 11/08/04 589.00 No
245 Vehicle Control Mass Torso/Dorsal, Small (1mm-5mm) 2 06/19/2006 11/08/04 589.00 No
245 Vehicle Control Thin 06/28/2006 11/08/04 598.00 Yes
245 Vehicle Control Mass Torso/Dorsal, Large (16mm And Larger) 1 06/28/2006 11/08/04 598.00 Yes
245 Vehicle Control Abnormal Breathing 06/28/2006 11/08/04 598.00 Yes
245 Vehicle Control Ruffled Fur 06/28/2006 11/08/04 598.00 Yes
245 Vehicle Control Lethargic 06/28/2006 11/08/04 598.00 Yes
253 312.5 mg/l Mass Torso/Lateral, Medium (6mm-15mm) 1 05/22/2006 11/08/04 561.00 No
253 312.5 mg/l Mass Torso/Lateral, Medium (6mm-15mm) 1 06/18/2006 11/08/04 588.00 Yes
265 312.5 mg/l Thin 05/14/2006 11/08/04 553.00 Yes
269 312.5 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 08/14/2006 11/08/04 645.00 No
269 312.5 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 09/11/2006 11/08/04 673.00 No
269 312.5 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 10/09/2006 11/08/04 701.00 No
269 312.5 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 11/07/2006 11/08/04 730.00 Yes
272 312.5 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 10/08/2006 11/08/04 700.00 Yes
275 312.5 mg/l Mass Head, Small (1mm-5mm) 1 09/11/2006 11/08/04 673.00 No
275 312.5 mg/l Mass Head, Small (1mm-5mm) 1 10/09/2006 11/08/04 701.00 No
275 312.5 mg/l Ulcer/Abscess Head 1 11/07/2006 11/08/04 730.00 Yes
275 312.5 mg/l Mass Head, Small (1mm-5mm) 1 11/07/2006 11/08/04 730.00 Yes
286 312.5 mg/l Mass Torso/Lateral, Medium (6mm-15mm) 1 07/17/2006 11/08/04 617.00 No
286 312.5 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 08/14/2006 11/08/04 645.00 No
286 312.5 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 09/11/2006 11/08/04 673.00 No
286 312.5 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 10/09/2006 11/08/04 701.00 No
286 312.5 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 10/19/2006 11/08/04 711.00 Yes
287 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 02/27/2006 11/08/04 477.00 No
287 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 03/27/2006 11/08/04 505.00 No
287 312.5 mg/l Diarrhea 03/27/2006 11/08/04 505.00 No
287 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 04/24/2006 11/08/04 533.00 No
287 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 05/22/2006 11/08/04 561.00 No
287 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 06/19/2006 11/08/04 589.00 No
287 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 07/17/2006 11/08/04 617.00 No
287 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 08/14/2006 11/08/04 645.00 No
287 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 09/11/2006 11/08/04 673.00 No
287 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 10/09/2006 11/08/04 701.00 No
287 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 11/06/2006 11/08/04 729.00 Yes
289 312.5 mg/l Abnormal Breathing 11/07/2006 11/08/04 730.00 Yes
289 312.5 mg/l Ruffled Fur 11/07/2006 11/08/04 730.00 Yes
289 312.5 mg/l Lethargic 11/07/2006 11/08/04 730.00 Yes
289 312.5 mg/l Thin 11/07/2006 11/08/04 730.00 Yes
292 312.5 mg/l Lethargic 10/26/2006 11/08/04 718.00 Yes
292 312.5 mg/l Abnormal Breathing 10/26/2006 11/08/04 718.00 Yes
294 312.5 mg/l Mass Head, Small (1mm-5mm) 1 04/24/2006 11/08/04 533.00 No
294 312.5 mg/l Thin 04/24/2006 11/08/04 533.00 Yes
294 312.5 mg/l Mass Head, Small (1mm-5mm) 1 04/24/2006 11/08/04 533.00 Yes
295 312.5 mg/l Lethargic 11/01/2006 11/08/04 724.00 Yes
295 312.5 mg/l Abnormal Breathing 11/01/2006 11/08/04 724.00 Yes
296 312.5 mg/l Eye Abnormality 08/14/2006 11/08/04 645.00 No
296 312.5 mg/l Eye Abnormality 09/11/2006 11/08/04 673.00 No
296 312.5 mg/l Eye Abnormality 10/09/2006 11/08/04 701.00 No
296 312.5 mg/l Eye Abnormality 11/07/2006 11/08/04 730.00 Yes
303 625 mg/l Ulcer/Abscess Torso/Lateral 1 10/09/2006 11/08/04 701.00 No
303 625 mg/l Ulcer/Abscess Torso/Lateral 1 10/12/2006 11/08/04 704.00 Yes
305 625 mg/l Eye Abnormality 04/24/2006 11/08/04 533.00 No
305 625 mg/l Eye Abnormality 05/22/2006 11/08/04 561.00 No
305 625 mg/l Eye Abnormality 06/19/2006 11/08/04 589.00 No
305 625 mg/l Eye Abnormality 07/17/2006 11/08/04 617.00 No
305 625 mg/l Eye Abnormality 08/14/2006 11/08/04 645.00 No
305 625 mg/l Eye Abnormality 09/11/2006 11/08/04 673.00 No
305 625 mg/l Eye Abnormality 10/09/2006 11/08/04 701.00 No
305 625 mg/l Eye Abnormality 11/08/2006 11/08/04 731.00 Yes
314 625 mg/l Thin 09/12/2005 11/08/04 309.00 No
314 625 mg/l Thin 09/12/2005 11/08/04 309.00 Yes
314 625 mg/l Lethargic 09/12/2005 11/08/04 309.00 Yes
314 625 mg/l Ruffled Fur 09/12/2005 11/08/04 309.00 Yes
317 625 mg/l Eye Abnormality 09/11/2006 11/08/04 673.00 No
317 625 mg/l Eye Abnormality 10/09/2006 11/08/04 701.00 No
317 625 mg/l Eye Abnormality 11/08/2006 11/08/04 731.00 Yes
321 625 mg/l Mass Appendage, Medium (6mm-15mm) 1 09/11/2006 11/08/04 673.00 No
321 625 mg/l Mass Appendage, Large (16mm And Larger) 1 10/09/2006 11/08/04 701.00 No
321 625 mg/l Mass Appendage, Large (16mm And Larger) 1 10/20/2006 11/08/04 712.00 Yes
324 625 mg/l Eye Abnormality 06/19/2006 11/08/04 589.00 No
324 625 mg/l Eye Abnormality 07/17/2006 11/08/04 617.00 No
324 625 mg/l Eye Abnormality 08/14/2006 11/08/04 645.00 No
324 625 mg/l Eye Abnormality 09/11/2006 11/08/04 673.00 No
324 625 mg/l Eye Abnormality 10/09/2006 11/08/04 701.00 No
324 625 mg/l Eye Abnormality 11/08/2006 11/08/04 731.00 Yes
326 625 mg/l Mass Appendage, Small (1mm-5mm) 1 06/19/2006 11/08/04 589.00 No
326 625 mg/l Mass Appendage, Small (1mm-5mm) 1 07/17/2006 11/08/04 617.00 No
326 625 mg/l Mass Appendage, Small (1mm-5mm) 1 08/14/2006 11/08/04 645.00 No
326 625 mg/l Mass Appendage, Small (1mm-5mm) 1 09/11/2006 11/08/04 673.00 No
326 625 mg/l Mass Appendage, Small (1mm-5mm) 1 10/09/2006 11/08/04 701.00 No
328 625 mg/l Mass Appendage, Medium (6mm-15mm) 1 07/17/2006 11/08/04 617.00 No
346 625 mg/l Mass Torso/Lateral, Medium (6mm-15mm) 1 09/11/2006 11/08/04 673.00 No
346 625 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 09/11/2006 11/08/04 673.00 No
346 625 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 10/09/2006 11/08/04 701.00 No
346 625 mg/l Mass Torso/Lateral, Medium (6mm-15mm) 1 10/09/2006 11/08/04 701.00 No
349 625 mg/l Mass Head, Medium (6mm-15mm) 1 08/14/2006 11/08/04 645.00 No
349 625 mg/l Mass Head, Large (16mm And Larger) 1 09/07/2006 11/08/04 669.00 Yes
354 1250 mg/l Mass Torso/Lateral, Large (16mm And Larger) 1 11/06/2006 11/08/04 729.00 Yes
355 1250 mg/l Mass Appendage, Medium (6mm-15mm) 1 10/09/2006 11/08/04 701.00 No
355 1250 mg/l Mass Appendage, Medium (6mm-15mm) 1 10/24/2006 11/08/04 716.00 Yes
357 1250 mg/l Mass Head, Small (1mm-5mm) 1 07/17/2006 11/08/04 617.00 No
357 1250 mg/l Mass Head, Small (1mm-5mm) 1 08/14/2006 11/08/04 645.00 No
357 1250 mg/l Thin 09/07/2006 11/08/04 669.00 Yes
357 1250 mg/l Ruffled Fur 09/07/2006 11/08/04 669.00 Yes
357 1250 mg/l Lethargic 09/07/2006 11/08/04 669.00 Yes
357 1250 mg/l Mass Head, Small (1mm-5mm) 1 09/07/2006 11/08/04 669.00 Yes
357 1250 mg/l Abnormal Breathing 09/07/2006 11/08/04 669.00 Yes
359 1250 mg/l Mass Torso/Ventral, Large (16mm And Larger) 1 07/12/2006 11/08/04 612.00 Yes
366 1250 mg/l Thin 04/24/2006 11/08/04 533.00 No
366 1250 mg/l Ruffled Fur 04/24/2006 11/08/04 533.00 Yes
366 1250 mg/l Thin 04/24/2006 11/08/04 533.00 Yes
368 1250 mg/l Thin 08/01/2006 11/08/04 632.00 Yes
369 1250 mg/l Mass Torso/Ventral, Large (16mm And Larger) 1 07/17/2006 11/08/04 617.00 No
369 1250 mg/l Mass Torso/Ventral, Medium (6mm-15mm) 1 08/14/2006 11/08/04 645.00 No
369 1250 mg/l Mass Torso/Ventral, Medium (6mm-15mm) 1 08/16/2006 11/08/04 647.00 Yes
373 1250 mg/l Mass Torso/Lateral, Small (1mm-5mm) 1 07/17/2006 11/08/04 617.00 No
373 1250 mg/l Mass Torso/Lateral, Small (1mm-5mm) 1 08/14/2006 11/08/04 645.00 No
373 1250 mg/l Mass Torso/Lateral, Medium (6mm-15mm) 1 09/11/2006 11/08/04 673.00 No
373 1250 mg/l Mass Torso/Lateral, Medium (6mm-15mm) 1 10/09/2006 11/08/04 701.00 No
373 1250 mg/l Mass Torso/Lateral, Medium (6mm-15mm) 1 10/29/2006 11/08/04 721.00 Yes
375 1250 mg/l Hindlimb Splay 08/14/2006 11/08/04 645.00 No
375 1250 mg/l Paralysis 08/17/2006 11/08/04 648.00 Yes
376 1250 mg/l Mass Head, Small (1mm-5mm) 1 07/17/2006 11/08/04 617.00 No
376 1250 mg/l Mass Head, Small (1mm-5mm) 1 08/14/2006 11/08/04 645.00 No
376 1250 mg/l Mass Head, Small (1mm-5mm) 1 09/11/2006 11/08/04 673.00 No
376 1250 mg/l Mass Head, Small (1mm-5mm) 1 10/09/2006 11/08/04 701.00 No
376 1250 mg/l Mass Head, Medium (6mm-15mm) 1 11/06/2006 11/08/04 729.00 Yes
384 1250 mg/l Thin 09/02/2006 11/08/04 664.00 Yes
388 1250 mg/l Eye Abnormality 08/14/2006 11/08/04 645.00 No
388 1250 mg/l Eye Abnormality 09/11/2006 11/08/04 673.00 No
388 1250 mg/l Eye Abnormality 10/09/2006 11/08/04 701.00 No
388 1250 mg/l Eye Abnormality 11/06/2006 11/08/04 729.00 Yes
394 1250 mg/l Abnormal Breathing 06/03/2006 11/08/04 573.00 Yes
394 1250 mg/l Lethargic 06/03/2006 11/08/04 573.00 Yes