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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: beta-Picoline
CASRN: ="108-99-6"
Study Number: C20009
Exposure Route: DOSED WATER
TDMS Number: 2000904
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
2 Vehicle Control Lethargic 05/05/2006 11/09/04 543.00 Yes
4 Vehicle Control Ulcer/Abscess Torso/Lateral 1 08/15/2006 11/09/04 645.00 No
4 Vehicle Control Thin 09/09/2006 11/09/04 670.00 Yes
4 Vehicle Control Lethargic 09/09/2006 11/09/04 670.00 Yes
4 Vehicle Control Abnormal Breathing 09/09/2006 11/09/04 670.00 Yes
4 Vehicle Control Ulcer/Abscess Torso/Lateral 1 09/09/2006 11/09/04 670.00 Yes
6 Vehicle Control Eye Abnormality 02/28/2006 11/09/04 477.00 No
6 Vehicle Control Mass Head, Small (1mm-5mm) 1 03/28/2006 11/09/04 505.00 No
6 Vehicle Control Eye Abnormality 03/28/2006 11/09/04 505.00 No
6 Vehicle Control Mass Head, Small (1mm-5mm) 1 04/25/2006 11/09/04 533.00 No
6 Vehicle Control Eye Abnormality 04/25/2006 11/09/04 533.00 No
6 Vehicle Control Mass Head, Small (1mm-5mm) 1 05/23/2006 11/09/04 561.00 No
6 Vehicle Control Eye Abnormality 05/23/2006 11/09/04 561.00 No
6 Vehicle Control Eye Abnormality 05/24/2006 11/09/04 562.00 Yes
6 Vehicle Control Mass Head, Small (1mm-5mm) 1 05/24/2006 11/09/04 562.00 Yes
7 Vehicle Control Eye Abnormality 10/10/2006 11/09/04 701.00 No
7 Vehicle Control Eye Abnormality 11/10/2006 11/09/04 732.00 Yes
8 Vehicle Control Ulcer/Abscess Torso/Ventral 2 09/12/2006 11/09/04 673.00 No
8 Vehicle Control Ulcer/Abscess Torso/Lateral 1 10/10/2006 11/09/04 701.00 No
8 Vehicle Control Ulcer/Abscess Torso/Ventral 1 10/10/2006 11/09/04 701.00 No
8 Vehicle Control Ulcer/Abscess Torso/Dorsal 1 10/10/2006 11/09/04 701.00 No
8 Vehicle Control Ulcer/Abscess Torso/Lateral 1 11/10/2006 11/09/04 732.00 Yes
8 Vehicle Control Ulcer/Abscess Torso/Dorsal 1 11/10/2006 11/09/04 732.00 Yes
8 Vehicle Control Ulcer/Abscess Torso/Ventral 1 11/10/2006 11/09/04 732.00 Yes
9 Vehicle Control Mass Head, Small (1mm-5mm) 1 07/18/2006 11/09/04 617.00 No
9 Vehicle Control Ruffled Fur 07/28/2006 11/09/04 627.00 Yes
9 Vehicle Control Thin 07/28/2006 11/09/04 627.00 Yes
10 Vehicle Control Lethargic 11/09/2006 11/09/04 731.00 Yes
10 Vehicle Control Abnormal Breathing 11/09/2006 11/09/04 731.00 Yes
17 Vehicle Control Nasal/Eye Discharge 07/20/2006 11/09/04 619.00 Yes
17 Vehicle Control Thin 07/20/2006 11/09/04 619.00 Yes
19 Vehicle Control Lethargic 08/15/2006 11/09/04 645.00 No
19 Vehicle Control Ruffled Fur 08/15/2006 11/09/04 645.00 No
19 Vehicle Control Lethargic 08/16/2006 11/09/04 646.00 Yes
19 Vehicle Control Ruffled Fur 08/16/2006 11/09/04 646.00 Yes
23 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 06/20/2006 11/09/04 589.00 No
23 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 07/18/2006 11/09/04 617.00 No
23 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 08/17/2006 11/09/04 647.00 No
23 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 09/12/2006 11/09/04 673.00 No
23 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 10/10/2006 11/09/04 701.00 No
23 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 11/10/2006 11/09/04 732.00 Yes
25 Vehicle Control Mass Head, Medium (6mm-15mm) 1 11/10/2006 11/09/04 732.00 Yes
25 Vehicle Control Eye Abnormality 11/10/2006 11/09/04 732.00 Yes
29 Vehicle Control Ruffled Fur 06/16/2006 11/09/04 585.00 Yes
29 Vehicle Control Abnormal Breathing 06/16/2006 11/09/04 585.00 Yes
29 Vehicle Control Thin 06/16/2006 11/09/04 585.00 Yes
29 Vehicle Control Lethargic 06/16/2006 11/09/04 585.00 Yes
39 Vehicle Control Lethargic 08/18/2006 11/09/04 648.00 Yes
39 Vehicle Control Abnormal Breathing 08/18/2006 11/09/04 648.00 Yes
41 Vehicle Control Thin 02/11/2006 11/09/04 460.00 Yes
45 Vehicle Control Lethargic 11/09/2006 11/09/04 731.00 Yes
45 Vehicle Control Abnormal Breathing 11/09/2006 11/09/04 731.00 Yes
47 Vehicle Control Abnormal Breathing 10/26/2006 11/09/04 717.00 Yes
47 Vehicle Control Thin 10/26/2006 11/09/04 717.00 Yes
47 Vehicle Control Lethargic 10/26/2006 11/09/04 717.00 Yes
49 Vehicle Control Eye Abnormality 10/11/2005 11/09/04 337.00 No
49 Vehicle Control Eye Abnormality 11/08/2005 11/09/04 365.00 No
49 Vehicle Control Eye Abnormality 12/06/2005 11/09/04 393.00 No
49 Vehicle Control Eye Abnormality 01/03/2006 11/09/04 421.00 No
49 Vehicle Control Eye Abnormality 01/31/2006 11/09/04 449.00 No
49 Vehicle Control Eye Abnormality 02/28/2006 11/09/04 477.00 No
49 Vehicle Control Eye Abnormality 03/28/2006 11/09/04 505.00 No
49 Vehicle Control Eye Abnormality 03/28/2006 11/09/04 505.00 Yes
54 312.5 mg/l Ulcer/Abscess Torso/Lateral 1 08/15/2006 11/09/04 645.00 No
54 312.5 mg/l Ulcer/Abscess Torso/Lateral 1 09/12/2006 11/09/04 673.00 No
54 312.5 mg/l Ulcer/Abscess Torso/Ventral 1 10/10/2006 11/09/04 701.00 No
54 312.5 mg/l Ulcer/Abscess Torso/Lateral 2 10/10/2006 11/09/04 701.00 No
54 312.5 mg/l Ulcer/Abscess Torso/Ventral 1 10/24/2006 11/09/04 715.00 Yes
54 312.5 mg/l Ulcer/Abscess Torso/Lateral 2 10/24/2006 11/09/04 715.00 Yes
55 312.5 mg/l Thin 06/20/2006 11/09/04 589.00 No
55 312.5 mg/l Ruffled Fur 06/20/2006 11/09/04 589.00 No
60 312.5 mg/l Mass Head, Small (1mm-5mm) 1 10/10/2006 11/09/04 701.00 No
60 312.5 mg/l Mass Head, Small (1mm-5mm) 1 11/10/2006 11/09/04 732.00 Yes
64 312.5 mg/l Lethargic 06/11/2006 11/09/04 580.00 Yes
64 312.5 mg/l Abnormal Breathing 06/11/2006 11/09/04 580.00 Yes
70 312.5 mg/l Lethargic 05/07/2006 11/09/04 545.00 Yes
70 312.5 mg/l Abnormal Breathing 05/07/2006 11/09/04 545.00 Yes
78 312.5 mg/l Thin 11/09/2006 11/09/04 731.00 Yes
78 312.5 mg/l Abnormal Breathing 11/09/2006 11/09/04 731.00 Yes
80 312.5 mg/l Lethargic 07/28/2006 11/09/04 627.00 Yes
80 312.5 mg/l Abnormal Breathing 07/28/2006 11/09/04 627.00 Yes
80 312.5 mg/l Ruffled Fur 07/28/2006 11/09/04 627.00 Yes
80 312.5 mg/l Thin 07/28/2006 11/09/04 627.00 Yes
83 312.5 mg/l Thin 07/15/2006 11/09/04 614.00 Yes
85 312.5 mg/l Eye Abnormality 06/20/2006 11/09/04 589.00 No
86 312.5 mg/l Abnormal Breathing 06/16/2006 11/09/04 585.00 Yes
86 312.5 mg/l Thin 06/16/2006 11/09/04 585.00 Yes
86 312.5 mg/l Lethargic 06/16/2006 11/09/04 585.00 Yes
86 312.5 mg/l Ruffled Fur 06/16/2006 11/09/04 585.00 Yes
89 312.5 mg/l Ruffled Fur 07/28/2006 11/09/04 627.00 Yes
89 312.5 mg/l Thin 07/28/2006 11/09/04 627.00 Yes
93 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 01/31/2006 11/09/04 449.00 No
93 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 02/28/2006 11/09/04 477.00 No
93 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 03/28/2006 11/09/04 505.00 No
93 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 04/25/2006 11/09/04 533.00 No
93 312.5 mg/l Mass Appendage, Small (1mm-5mm) 1 05/23/2006 11/09/04 561.00 No
93 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 06/20/2006 11/09/04 589.00 No
93 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 07/18/2006 11/09/04 617.00 No
93 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 08/15/2006 11/09/04 645.00 No
93 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 09/12/2006 11/09/04 673.00 No
93 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 10/10/2006 11/09/04 701.00 No
93 312.5 mg/l Mass Appendage, Medium (6mm-15mm) 1 11/10/2006 11/09/04 732.00 Yes
96 312.5 mg/l Eye Abnormality 03/28/2006 11/09/04 505.00 No
96 312.5 mg/l Eye Abnormality 04/25/2006 11/09/04 533.00 No
96 312.5 mg/l Eye Abnormality 05/23/2006 11/09/04 561.00 No
96 312.5 mg/l Eye Abnormality 06/20/2006 11/09/04 589.00 No
96 312.5 mg/l Eye Abnormality 07/18/2006 11/09/04 617.00 No
96 312.5 mg/l Eye Abnormality 08/15/2006 11/09/04 645.00 No
96 312.5 mg/l Eye Abnormality 09/12/2006 11/09/04 673.00 No
96 312.5 mg/l Eye Abnormality 10/10/2006 11/09/04 701.00 No
96 312.5 mg/l Eye Abnormality 10/11/2006 11/09/04 702.00 Yes
108 625 mg/l Ruffled Fur 02/07/2006 11/09/04 456.00 Yes
108 625 mg/l Thin 02/07/2006 11/09/04 456.00 Yes
110 625 mg/l Eye Abnormality 06/20/2006 11/09/04 589.00 No
110 625 mg/l Eye Abnormality 07/18/2006 11/09/04 617.00 No
110 625 mg/l Mass Head, Small (1mm-5mm) 1 07/18/2006 11/09/04 617.00 No
110 625 mg/l Mass Head, Small (1mm-5mm) 1 08/15/2006 11/09/04 645.00 No
110 625 mg/l Mass Head, Medium (6mm-15mm) 1 09/12/2006 11/09/04 673.00 No
110 625 mg/l Mass Head, Medium (6mm-15mm) 1 10/10/2006 11/09/04 701.00 No
110 625 mg/l Mass Head, Medium (6mm-15mm) 1 11/09/2006 11/09/04 731.00 Yes
110 625 mg/l Eye Abnormality 11/09/2006 11/09/04 731.00 Yes
112 625 mg/l Mass Torso/Ventral, Large (16mm And Larger) 1 11/09/2006 11/09/04 731.00 Yes
117 625 mg/l Thin 11/08/2006 11/09/04 730.00 Yes
117 625 mg/l Lethargic 11/08/2006 11/09/04 730.00 Yes
118 625 mg/l Thin 10/09/2006 11/09/04 700.00 Yes
118 625 mg/l Lethargic 10/09/2006 11/09/04 700.00 Yes
118 625 mg/l Ruffled Fur 10/09/2006 11/09/04 700.00 Yes
120 625 mg/l Abnormal Breathing 11/08/2006 11/09/04 730.00 Yes
123 625 mg/l Thin 04/16/2006 11/09/04 524.00 Yes
123 625 mg/l Eye Abnormality 04/16/2006 11/09/04 524.00 Yes
123 625 mg/l Lethargic 04/16/2006 11/09/04 524.00 Yes
123 625 mg/l Abnormal Breathing 04/16/2006 11/09/04 524.00 Yes
124 625 mg/l Ruffled Fur 02/21/2006 11/09/04 470.00 Yes
124 625 mg/l Thin 02/21/2006 11/09/04 470.00 Yes
132 625 mg/l Mass Head, Small (1mm-5mm) 1 08/15/2006 11/09/04 645.00 No
132 625 mg/l Mass Head, Small (1mm-5mm) 1 09/12/2006 11/09/04 673.00 No
132 625 mg/l Mass Head, Small (1mm-5mm) 1 10/10/2006 11/09/04 701.00 No
132 625 mg/l Mass Head, Small (1mm-5mm) 1 10/16/2006 11/09/04 707.00 Yes
134 625 mg/l Ulcer/Abscess Torso/Dorsal 2 07/18/2006 11/09/04 617.00 No
134 625 mg/l Ulcer/Abscess Torso/Dorsal 2 08/15/2006 11/09/04 645.00 No
134 625 mg/l Ulcer/Abscess Torso/Dorsal 2 09/12/2006 11/09/04 673.00 No
134 625 mg/l Ulcer/Abscess Torso/Dorsal 2 10/10/2006 11/09/04 701.00 No
139 625 mg/l Mass Appendage, Medium (6mm-15mm) 1 07/18/2006 11/09/04 617.00 No
139 625 mg/l Mass Appendage, Medium (6mm-15mm) 1 08/15/2006 11/09/04 645.00 No
139 625 mg/l Mass Appendage, Medium (6mm-15mm) 1 08/29/2006 11/09/04 659.00 Yes
140 625 mg/l Eye Abnormality 10/10/2006 11/09/04 701.00 No
140 625 mg/l Lethargic 11/10/2006 11/09/04 732.00 Yes
140 625 mg/l Eye Abnormality 11/10/2006 11/09/04 732.00 Yes
140 625 mg/l Abnormal Breathing 11/10/2006 11/09/04 732.00 Yes
141 625 mg/l Thin 11/10/2006 11/09/04 732.00 Yes
144 625 mg/l Lethargic 10/13/2006 11/09/04 704.00 Yes
144 625 mg/l Ruffled Fur 10/13/2006 11/09/04 704.00 Yes
145 625 mg/l Abnormal Breathing 08/01/2006 11/09/04 631.00 Yes
145 625 mg/l Lethargic 08/01/2006 11/09/04 631.00 Yes
146 625 mg/l Thin 02/28/2006 11/09/04 477.00 No
148 625 mg/l Lethargic 07/28/2006 11/09/04 627.00 Yes
148 625 mg/l Thin 07/28/2006 11/09/04 627.00 Yes
148 625 mg/l Abnormal Breathing 07/28/2006 11/09/04 627.00 Yes
153 1250 mg/l Thin 04/26/2006 11/09/04 534.00 Yes
155 1250 mg/l Lethargic 02/16/2006 11/09/04 465.00 Yes
155 1250 mg/l Abnormal Breathing 02/16/2006 11/09/04 465.00 Yes
155 1250 mg/l Ruffled Fur 02/16/2006 11/09/04 465.00 Yes
156 1250 mg/l Thin 11/10/2006 11/09/04 732.00 Yes
156 1250 mg/l Lethargic 11/10/2006 11/09/04 732.00 Yes
156 1250 mg/l Abnormal Breathing 11/10/2006 11/09/04 732.00 Yes
163 1250 mg/l Thin 04/26/2006 11/09/04 534.00 Yes
166 1250 mg/l Eye Abnormality 06/20/2006 11/09/04 589.00 No
166 1250 mg/l Eye Abnormality 07/18/2006 11/09/04 617.00 No
166 1250 mg/l Eye Abnormality 08/15/2006 11/09/04 645.00 No
166 1250 mg/l Eye Abnormality 09/12/2006 11/09/04 673.00 No
166 1250 mg/l Eye Abnormality 10/10/2006 11/09/04 701.00 No
166 1250 mg/l Eye Abnormality 11/09/2006 11/09/04 731.00 Yes
170 1250 mg/l Lethargic 10/19/2006 11/09/04 710.00 Yes
170 1250 mg/l Ruffled Fur 10/19/2006 11/09/04 710.00 Yes
170 1250 mg/l Abnormal Breathing 10/19/2006 11/09/04 710.00 Yes
172 1250 mg/l Eye Abnormality 08/15/2006 11/09/04 645.00 No
172 1250 mg/l Eye Abnormality 09/12/2006 11/09/04 673.00 No
172 1250 mg/l Eye Abnormality 10/10/2006 11/09/04 701.00 No
172 1250 mg/l Eye Abnormality 11/09/2006 11/09/04 731.00 Yes
178 1250 mg/l Ruffled Fur 11/02/2006 11/09/04 724.00 Yes
178 1250 mg/l Thin 11/02/2006 11/09/04 724.00 Yes
178 1250 mg/l Abnormal Breathing 11/02/2006 11/09/04 724.00 Yes
178 1250 mg/l Lethargic 11/02/2006 11/09/04 724.00 Yes
180 1250 mg/l Thin 03/28/2006 11/09/04 505.00 No
183 1250 mg/l Mass Appendage, Small (1mm-5mm) 1 11/09/2006 11/09/04 731.00 Yes
186 1250 mg/l Eye Abnormality 06/20/2006 11/09/04 589.00 No
186 1250 mg/l Eye Abnormality 07/18/2006 11/09/04 617.00 No
186 1250 mg/l Eye Abnormality 08/15/2006 11/09/04 645.00 No
186 1250 mg/l Eye Abnormality 09/12/2006 11/09/04 673.00 No
186 1250 mg/l Eye Abnormality 10/10/2006 11/09/04 701.00 No
186 1250 mg/l Eye Abnormality 11/08/2006 11/09/04 730.00 Yes
192 1250 mg/l Eye Abnormality 06/20/2006 11/09/04 589.00 No
192 1250 mg/l Eye Abnormality 07/18/2006 11/09/04 617.00 No
192 1250 mg/l Eye Abnormality 08/15/2006 11/09/04 645.00 No
192 1250 mg/l Eye Abnormality 09/12/2006 11/09/04 673.00 No
192 1250 mg/l Eye Abnormality 10/10/2006 11/09/04 701.00 No
192 1250 mg/l Mass Head, Medium (6mm-15mm) 1 11/09/2006 11/09/04 731.00 Yes
192 1250 mg/l Eye Abnormality 11/09/2006 11/09/04 731.00 Yes
194 1250 mg/l Eye Abnormality 02/28/2006 11/09/04 477.00 No
194 1250 mg/l Eye Abnormality 03/28/2006 11/09/04 505.00 No
194 1250 mg/l Eye Abnormality 04/25/2006 11/09/04 533.00 No
194 1250 mg/l Mass Head, Medium (6mm-15mm) 1 04/26/2006 11/09/04 534.00 Yes
194 1250 mg/l Eye Abnormality 04/26/2006 11/09/04 534.00 Yes
195 1250 mg/l Abnormal Breathing 11/10/2006 11/09/04 732.00 Yes
195 1250 mg/l Thin 11/10/2006 11/09/04 732.00 Yes
195 1250 mg/l Lethargic 11/10/2006 11/09/04 732.00 Yes
196 1250 mg/l Eye Abnormality 01/03/2006 11/09/04 421.00 No
196 1250 mg/l Eye Abnormality 01/31/2006 11/09/04 449.00 No
196 1250 mg/l Eye Abnormality 02/28/2006 11/09/04 477.00 No
196 1250 mg/l Eye Abnormality 03/28/2006 11/09/04 505.00 No
196 1250 mg/l Eye Abnormality 04/25/2006 11/09/04 533.00 No
196 1250 mg/l Eye Abnormality 05/23/2006 11/09/04 561.00 No
196 1250 mg/l Eye Abnormality 06/20/2006 11/09/04 589.00 No
196 1250 mg/l Eye Abnormality 07/18/2006 11/09/04 617.00 No
196 1250 mg/l Eye Abnormality 08/15/2006 11/09/04 645.00 No
196 1250 mg/l Eye Abnormality 09/12/2006 11/09/04 673.00 No
196 1250 mg/l Eye Abnormality 10/10/2006 11/09/04 701.00 No
196 1250 mg/l Ruffled Fur 10/26/2006 11/09/04 717.00 Yes
196 1250 mg/l Thin 10/26/2006 11/09/04 717.00 Yes
196 1250 mg/l Lethargic 10/26/2006 11/09/04 717.00 Yes
197 1250 mg/l Mass Torso/Lateral, Medium (6mm-15mm) 1 11/10/2006 11/09/04 732.00 Yes
199 1250 mg/l Abnormal Breathing 11/09/2006 11/09/04 731.00 Yes