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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Cobalt
CASRN: ="7440-48-4"
Study Number: C60311
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 6031102
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Respiratory System Lung Alv/Bron Epith 2.5 MG/M3 5 4 301 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 2.5 MG/M3 5 4 303 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 2.5 MG/M3 5 4 304 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 5 MG/M3 5 6 501 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 5 MG/M3 5 6 502 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 5 MG/M3 5 6 504 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 5 MG/M3 5 6 505 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 8 701 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 8 702 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 8 703 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 8 704 17 1 Karyomegaly Mild Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 8 705 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 20 MG/M3 5 10 901 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 20 MG/M3 5 10 903 17 1 Karyomegaly Mild Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 20 MG/M3 5 10 904 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 20 MG/M3 5 10 905 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 40 MG/M3 5 12 1104 9 1 Karyomegaly Minimal Natural Death
Respiratory System Lung Alv/Bron Epith 40 MG/M3 5 12 1105 7 1 Karyomegaly Minimal Natural Death
Respiratory System Lung Alv/Bron Epith 40 MG/M3 5 12 1102 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 40 MG/M3 5 12 1103 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alveolus 2.5 MG/M3 5 4 302 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 2.5 MG/M3 5 4 305 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 6 501 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 6 502 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 6 503 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 6 504 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 6 505 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 8 701 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 8 702 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 8 703 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 8 704 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 8 705 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 10 901 17 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 10 902 17 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 10 903 17 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 10 904 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 10 905 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 40 MG/M3 5 12 1101 6 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 12 1104 9 1 Infiltration Cellular Mild, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 12 1105 7 1 Infiltration Cellular Moderate, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 12 1102 17 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 40 MG/M3 5 12 1103 17 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 4 302 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 4 305 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 501 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 502 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 503 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 505 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 702 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 703 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 704 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 10 901 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 10 902 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 12 1102 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 8 703 17 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 8 704 17 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 10 901 17 1 Fibrosis Moderate Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 10 902 17 1 Fibrosis Mild Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 10 903 17 1 Fibrosis Marked Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 10 904 17 1 Fibrosis Moderate Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 10 905 17 1 Fibrosis Mild Terminal Sacrifice
Respiratory System Lung Interstitium 40 MG/M3 5 12 1102 17 1 Fibrosis Marked Terminal Sacrifice
Respiratory System Lung Interstitium 40 MG/M3 5 12 1103 17 1 Fibrosis Moderate Terminal Sacrifice
Respiratory System Lung 5 MG/M3 5 6 502 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Lung 5 MG/M3 5 6 503 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Lung 10 MG/M3 5 8 704 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Lung 20 MG/M3 5 10 902 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Lung 20 MG/M3 5 10 903 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Lung 20 MG/M3 5 10 905 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Lung 40 MG/M3 5 12 1101 6 1 Inflammation Mild, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 12 1103 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 301 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 302 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 303 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 304 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 305 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 501 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 502 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 503 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 504 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 505 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 701 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 702 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 703 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 704 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 705 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 901 17 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 902 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 903 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 904 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 905 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1101 6 1 Atrophy Mild Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1102 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1103 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 303 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 304 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 305 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 501 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 502 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 503 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 504 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 505 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 701 17 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 705 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 901 17 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 902 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 904 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 905 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1101 6 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1104 9 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1102 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 8 705 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 902 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 903 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 905 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1103 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1101 6 1 Necrosis Mild Natural Death
Respiratory System Nose Respirat Epith 2.5 MG/M3 5 4 301 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 MG/M3 5 4 302 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 MG/M3 5 4 303 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 MG/M3 5 4 304 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 MG/M3 5 4 305 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 6 501 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 6 502 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 6 503 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 6 504 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 6 505 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 8 701 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 8 702 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 8 703 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 8 704 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 8 705 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 901 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 902 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 903 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 904 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1101 6 1 Vacuolization Cytoplasmic Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1104 9 1 Vacuolization Cytoplasmic Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1102 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1103 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose 5 MG/M3 5 6 501 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 5 MG/M3 5 6 502 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 5 MG/M3 5 6 503 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 5 MG/M3 5 6 504 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 5 MG/M3 5 6 505 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 8 701 17 1 Inflammation Moderate, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 8 702 17 1 Inflammation Moderate, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 8 703 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 8 704 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 8 705 17 1 Inflammation Moderate, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 10 901 17 1 Inflammation Moderate, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 10 902 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 10 903 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 10 904 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 10 905 17 1 Inflammation Moderate, Acute Terminal Sacrifice
Respiratory System Nose 40 MG/M3 5 12 1101 6 1 Inflammation Mild, Acute Natural Death
Respiratory System Nose 40 MG/M3 5 12 1104 9 1 Inflammation Minimal, Acute Natural Death
Respiratory System Nose 40 MG/M3 5 12 1105 7 1 Inflammation Mild, Acute Natural Death
Respiratory System Nose 40 MG/M3 5 12 1102 17 1 Inflammation Moderate, Acute Terminal Sacrifice
Respiratory System Nose 40 MG/M3 5 12 1103 17 1 Inflammation Moderate, Acute Terminal Sacrifice