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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Cobalt
CASRN: ="7440-48-4"
Study Number: C60311
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 6031102
Sex: Male
Strain and Species: B6C3F1 Mice

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Respiratory System Lung Alv/Bron Epith 5 MG/M3 5 5 401 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 5 MG/M3 5 5 402 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 5 MG/M3 5 5 403 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 5 MG/M3 5 5 404 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 7 601 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 7 602 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 7 603 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 7 604 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 10 MG/M3 5 7 605 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 20 MG/M3 5 9 801 17 1 Karyomegaly Mild Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 20 MG/M3 5 9 802 17 1 Karyomegaly Minimal Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 20 MG/M3 5 9 803 17 1 Karyomegaly Mild Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 20 MG/M3 5 9 804 17 1 Karyomegaly Mild Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 20 MG/M3 5 9 805 17 1 Karyomegaly Mild Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 40 MG/M3 5 11 1003 5 1 Karyomegaly Minimal Natural Death
Respiratory System Lung Alv/Bron Epith 40 MG/M3 5 11 1005 8 1 Karyomegaly Minimal Natural Death
Respiratory System Lung Alv/Bron Epith 40 MG/M3 5 11 1002 17 1 Karyomegaly Mild Terminal Sacrifice
Respiratory System Lung Alv/Bron Epith 40 MG/M3 5 11 1004 17 1 Karyomegaly Mild Terminal Sacrifice
Respiratory System Lung Alveolus 2.5 MG/M3 5 3 201 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 2.5 MG/M3 5 3 204 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 5 401 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 5 402 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 5 403 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 5 404 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 5 405 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 7 601 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 7 602 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 7 603 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 7 604 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 7 605 17 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 9 801 17 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 9 802 17 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 9 803 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 9 804 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 9 805 17 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 40 MG/M3 5 11 1001 5 1 Infiltration Cellular Mild, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 11 1003 5 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 11 1005 8 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 11 1002 17 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 40 MG/M3 5 11 1004 17 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 11 1001 5 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 3 201 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 3 202 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 3 204 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 3 205 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 5 401 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 5 402 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 5 405 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 601 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 602 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 603 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 604 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 605 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 9 801 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 9 804 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 9 805 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 11 1005 8 1 Vacuolization Cytoplasmic Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 11 1002 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 11 1004 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 7 601 17 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 7 602 17 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 7 605 17 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 9 801 17 1 Fibrosis Moderate Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 9 802 17 1 Fibrosis Mild Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 9 803 17 1 Fibrosis Mild Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 9 804 17 1 Fibrosis Mild Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 9 805 17 1 Fibrosis Mild Terminal Sacrifice
Respiratory System Lung Interstitium 40 MG/M3 5 11 1005 8 1 Fibrosis Minimal Natural Death
Respiratory System Lung Interstitium 40 MG/M3 5 11 1002 17 1 Fibrosis Moderate Terminal Sacrifice
Respiratory System Lung Interstitium 40 MG/M3 5 11 1004 17 1 Fibrosis Marked Terminal Sacrifice
Respiratory System Lung 40 MG/M3 5 11 1001 5 1 Inflammation Mild, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 11 1003 5 1 Inflammation Minimal, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 11 1005 8 1 Inflammation Mild, Acute Natural Death
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 201 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 202 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 203 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 204 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 205 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 401 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 402 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 403 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 404 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 405 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 601 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 602 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 603 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 604 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 605 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 801 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 802 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 803 17 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 804 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 805 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1003 5 1 Atrophy Mild Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1005 8 1 Atrophy Minimal Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1002 17 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1004 17 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 203 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 204 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 401 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 402 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 404 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 801 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 802 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 803 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 804 17 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 805 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1001 5 1 Necrosis Mild Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1003 5 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1005 8 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1002 17 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1004 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 602 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 603 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 604 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 605 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 801 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 802 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 803 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 805 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1002 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1004 17 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1002 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1004 17 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 MG/M3 5 3 202 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 MG/M3 5 3 203 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 MG/M3 5 3 204 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 MG/M3 5 3 205 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 5 401 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 5 402 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 5 403 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 5 404 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 5 MG/M3 5 5 405 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 601 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 602 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 603 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 604 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 801 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 802 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 803 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 804 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 805 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1001 5 1 Vacuolization Cytoplasmic Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1003 5 1 Vacuolization Cytoplasmic Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1005 8 1 Vacuolization Cytoplasmic Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1002 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1004 17 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Nose 5 MG/M3 5 5 402 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 7 601 17 1 Inflammation Moderate, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 7 602 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 7 603 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 7 604 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 7 605 17 1 Inflammation Moderate, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 9 801 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 9 802 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 9 803 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 9 804 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 20 MG/M3 5 9 805 17 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Nose 40 MG/M3 5 11 1001 5 1 Inflammation Minimal, Acute Natural Death
Respiratory System Nose 40 MG/M3 5 11 1003 5 1 Inflammation Mild, Acute Natural Death
Respiratory System Nose 40 MG/M3 5 11 1005 8 1 Inflammation Minimal, Acute Natural Death
Respiratory System Nose 40 MG/M3 5 11 1002 17 1 Inflammation Mild, Acute Terminal Sacrifice
Respiratory System Nose 40 MG/M3 5 11 1004 17 1 Inflammation Moderate, Acute Terminal Sacrifice