If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Cobalt
CASRN: ="7440-48-4"
Study Number: C60311
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 6031101
Sex: Male
Strain and Species: F 344/N Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Nervous System Brain 40 MG/M3 5 11 1005 7 1 Hemorrhage Minimal Natural Death
Respiratory System Lung Alveolar Epith 20 MG/M3 5 9 801 5 1 Hyperplasia Mild Natural Death
Respiratory System Lung Alveolar Epith 20 MG/M3 5 9 802 5 1 Hyperplasia Minimal Natural Death
Respiratory System Lung Alveolar Epith 20 MG/M3 5 9 803 9 1 Hyperplasia Mild Natural Death
Respiratory System Lung Alveolar Epith 40 MG/M3 5 11 1001 5 1 Hyperplasia Minimal Natural Death
Respiratory System Lung Alveolar Epith 40 MG/M3 5 11 1002 7 1 Hyperplasia Moderate Natural Death
Respiratory System Lung Alveolar Epith 40 MG/M3 5 11 1003 6 1 Hyperplasia Minimal Natural Death
Respiratory System Lung Alveolar Epith 40 MG/M3 5 11 1004 6 1 Hyperplasia Minimal Natural Death
Respiratory System Lung Alveolar Epith 40 MG/M3 5 11 1005 7 1 Hyperplasia Minimal Natural Death
Respiratory System Lung Alveolus 5 MG/M3 5 5 401 16 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 5 402 16 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 5 403 16 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 5 MG/M3 5 5 405 16 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 7 601 16 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 7 602 16 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 10 MG/M3 5 7 605 16 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 9 805 13 1 Infiltration Cellular Mild, Histiocyte Moribund Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 9 801 5 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 20 MG/M3 5 9 802 5 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 20 MG/M3 5 9 803 9 1 Infiltration Cellular Moderate, Histiocyte Natural Death
Respiratory System Lung Alveolus 20 MG/M3 5 9 804 5 1 Infiltration Cellular Moderate, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 11 1001 5 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 11 1002 7 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 11 1003 6 1 Infiltration Cellular Mild, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 11 1004 6 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 11 1005 7 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 9 801 5 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 9 802 5 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 11 1002 7 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 11 1003 6 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 11 1005 7 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 3 201 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 3 202 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 3 203 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 3 204 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 3 205 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 5 401 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 5 402 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 5 403 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 5 404 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 5 405 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 601 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 602 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 603 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 604 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 7 605 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 9 805 13 1 Vacuolization Cytoplasmic Mild Moribund Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 7 601 16 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 7 602 16 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 7 603 16 1 Fibrosis Mild Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 7 604 16 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 7 605 16 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 9 805 13 1 Fibrosis Marked Moribund Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 9 803 9 1 Fibrosis Mild Natural Death
Respiratory System Lung 10 MG/M3 5 7 605 16 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung 20 MG/M3 5 9 805 13 1 Hemorrhage Minimal Moribund Sacrifice
Respiratory System Lung 20 MG/M3 5 9 801 5 1 Hemorrhage Minimal Natural Death
Respiratory System Lung 20 MG/M3 5 9 802 5 1 Hemorrhage Minimal Natural Death
Respiratory System Lung 20 MG/M3 5 9 803 9 1 Hemorrhage Mild Natural Death
Respiratory System Lung 20 MG/M3 5 9 804 5 1 Hemorrhage Minimal Natural Death
Respiratory System Lung 40 MG/M3 5 11 1001 5 1 Hemorrhage Moderate Natural Death
Respiratory System Lung 40 MG/M3 5 11 1002 7 1 Hemorrhage Marked Natural Death
Respiratory System Lung 40 MG/M3 5 11 1003 6 1 Hemorrhage Mild Natural Death
Respiratory System Lung 40 MG/M3 5 11 1004 6 1 Hemorrhage Moderate Natural Death
Respiratory System Lung 40 MG/M3 5 11 1005 7 1 Hemorrhage Moderate Natural Death
Respiratory System Lung 20 MG/M3 5 9 801 5 1 Inflammation Mild, Acute Natural Death
Respiratory System Lung 20 MG/M3 5 9 802 5 1 Inflammation Minimal, Acute Natural Death
Respiratory System Lung 20 MG/M3 5 9 803 9 1 Inflammation Minimal, Acute Natural Death
Respiratory System Lung 20 MG/M3 5 9 804 5 1 Inflammation Minimal, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 11 1001 5 1 Inflammation Mild, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 11 1002 7 1 Inflammation Mild, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 11 1003 6 1 Inflammation Mild, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 11 1004 6 1 Inflammation Mild, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 11 1005 7 1 Inflammation Mild, Acute Natural Death
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 201 16 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 202 16 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 203 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 204 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 205 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 401 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 402 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 403 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 404 16 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 405 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 601 16 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 602 16 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 603 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 604 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 605 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 805 13 1 Atrophy Moderate Moribund Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 801 5 1 Atrophy Minimal Natural Death
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 803 9 1 Atrophy Minimal Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1001 5 1 Atrophy Minimal Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1002 7 1 Atrophy Mild Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1005 7 1 Atrophy Mild Natural Death
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 201 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 203 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 3 204 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 401 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 403 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 404 16 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 5 405 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 602 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 603 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 604 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 7 605 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 805 13 1 Necrosis Mild Moribund Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 802 5 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 803 9 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 20 MG/M3 5 9 804 5 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1001 5 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1002 7 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1003 6 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1004 6 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 11 1005 7 1 Necrosis Moderate Natural Death
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 605 16 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 805 13 1 Metaplasia Minimal, Squamous Moribund Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 803 9 1 Metaplasia Minimal, Squamous Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1005 7 1 Metaplasia Minimal, Squamous Natural Death
Respiratory System Nose Respirat Epith 10 MG/M3 5 7 605 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 801 5 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 803 9 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 20 MG/M3 5 9 804 5 1 Necrosis Mild Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1001 5 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1002 7 1 Necrosis Mild Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1003 6 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1004 6 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 11 1005 7 1 Necrosis Mild Natural Death
Respiratory System Nose 10 MG/M3 5 7 604 16 1 Foreign Body Terminal Sacrifice
Respiratory System Nose 2.5 MG/M3 5 3 204 16 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Nose 10 MG/M3 5 7 605 16 1 Inflammation Minimal, Acute Terminal Sacrifice
Urinary System Urinary Bladder Muscularis, Serosa 20 MG/M3 5 9 805 13 1 Edema Moderate Moribund Sacrifice