If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Perfluorooctane Sulfonate
CASRN: ="1763-23-1"
Study Number: C20617
Exposure Route: GAVAGE
TDMS Number: 2061701
Sex: Male
Strain and Species: HSD Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 55 331 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 56 339 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 56 340 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 57 341 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 57 342 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 57 343 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 57 344 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 57 345 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 58 348 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 58 349 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 58 350 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 59 351 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 59 352 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 59 353 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 59 354 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 59 355 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 60 356 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 60 357 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 60 358 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 60 359 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 60 360 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 57 345 29 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 58 346 29 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 59 353 29 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 60 358 29 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 60 359 29 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 60 360 29 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 50 307 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .312 mg/kg 10 51 313 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .312 mg/kg 10 51 314 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .312 mg/kg 10 52 316 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .312 mg/kg 10 52 320 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .625 mg/kg 10 54 327 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 2.5 mg/kg 10 57 344 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 2.5 mg/kg 10 57 345 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 2.5 mg/kg 10 58 346 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 5 mg/kg 10 59 353 29 1 Inflammation Minimal, Focal, Granulomatous Terminal Sacrifice
Cardiovascular System Heart Epicardium Vehicle Control 10 49 303 29 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Genital System Prostate Vehicle Control 10 49 304 29 1 Inflammation Minimal, Chronic Terminal Sacrifice
Hematopoietic System Bone Marrow 1.25 mg/kg 10 55 331 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 1.25 mg/kg 10 55 335 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 1.25 mg/kg 10 56 336 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 1.25 mg/kg 10 56 337 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 1.25 mg/kg 10 56 340 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 57 342 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 57 343 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 57 344 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 58 348 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 59 351 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 59 352 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 59 354 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 59 355 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 60 356 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 60 357 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 60 358 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 60 359 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 49 302 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen .312 mg/kg 10 52 318 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen .625 mg/kg 10 53 323 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen .625 mg/kg 10 54 326 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 55 331 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 55 332 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 55 334 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 56 337 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 56 338 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 56 339 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 56 340 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 57 341 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 57 342 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 57 343 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 57 344 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 57 345 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 58 347 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 58 349 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 58 350 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 59 351 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 59 352 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 59 353 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 59 354 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 59 355 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 60 356 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 60 357 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 60 358 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 60 359 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 60 360 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Respiratory System Lung Alveolus Vehicle Control 10 50 306 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Respiratory System Lung Alveolus 5 mg/kg 10 59 354 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 mg/kg 10 57 345 29 1 Fibrosis Mild, Focal Terminal Sacrifice
Respiratory System Nose Respirat Epith Vehicle Control 10 50 307 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith Vehicle Control 10 50 309 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith Vehicle Control 10 50 310 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 321 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 322 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 323 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 324 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 325 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 54 330 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 55 332 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 55 333 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 55 334 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 55 335 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith Vehicle Control 10 50 307 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith Vehicle Control 10 50 308 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith Vehicle Control 10 50 309 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith Vehicle Control 10 50 310 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 321 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 322 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 323 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 324 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith .625 mg/kg 10 53 325 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 55 332 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 55 333 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 55 334 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 55 335 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 56 338 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 mg/kg 10 57 345 29 1 Inflammation Minimal, Focal, Granulomatous Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 mg/kg 10 57 345 29 1 Ulcer Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 49 302 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 49 303 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 49 304 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 49 305 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 50 306 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 50 307 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 50 308 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 50 309 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 50 310 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .312 mg/kg 10 51 311 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .312 mg/kg 10 51 312 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .312 mg/kg 10 51 314 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .312 mg/kg 10 51 315 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .312 mg/kg 10 52 316 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .312 mg/kg 10 52 318 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .312 mg/kg 10 52 319 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .312 mg/kg 10 52 320 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .625 mg/kg 10 53 321 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .625 mg/kg 10 53 322 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .625 mg/kg 10 53 323 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .625 mg/kg 10 53 324 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .625 mg/kg 10 53 325 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .625 mg/kg 10 54 330 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 55 331 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 55 333 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 55 334 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 55 335 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 56 336 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 56 337 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 56 338 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 56 339 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 2.5 mg/kg 10 57 342 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 2.5 mg/kg 10 57 343 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 2.5 mg/kg 10 57 344 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 2.5 mg/kg 10 57 345 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 5 mg/kg 10 59 351 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 5 mg/kg 10 59 354 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 5 mg/kg 10 59 355 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 5 mg/kg 10 60 356 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 5 mg/kg 10 60 360 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice