Multigenerational reproductive assessment of 4-methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats
Mamta Behl, Cynthia J Willson, Helen Cunny, Paul M D Foster, Barry McIntyre, Cynthia Shackelford, Keith R Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R Blystone
Reproductive Toxicology (2020)
DOI:
https://doi.org/10.1016/j.reprotox.2020.03.005
PMID:
32229253
DOI:
https://doi.org/10.22427/NTP-DATA-002-01511-0000-0000-0
Reproductive Assessment Through Continuous Breeding
Study Information
- 4-MI Readme File (16KB)
DRF Study Tables
- I01 - Animal Removal Summary (52KB)
- I02 - Animal Removals (317KB)
- I03 - Growth Curve (183KB)
- I04 - Mean Body Weights (366KB)
- I04G - Mean Body Weight Gain (87KB)
- I05 - Clinical Observationss Summary (164KB)
- I05P - Pup Clinical Observations Summary (237KB)
- I06 - Mean Feed Consumption (297KB)
- I08 - Mean Test Compound Consumption (224KB)
- PA46 - Gross Pathology Summary (105KB)
- R01 - Multigeneration Cross Reference (731KB)
- R02 - Reproductive Performance Summary (45KB)
- R03 - Litter Data Summary (62KB)
- R19 - Pup Mean Body Weight Summary (156KB)
- R19G - Pup Mean Body Weight Gain (135KB)
- R20 - Pup Necropsy Summary (61KB)
DRF Individual Animal Data
- Individual Animal Body Weight Data (69KB)
- Individual Animal Clinical Observations Data (188KB)
- Individual Animal Consumption Data (87KB)
- Individual Animal Gross Pathology Data (5KB)
- Individual Animal Litter Data (36KB)
- Individual Animal Pup Body Weight Data (57KB)
- Individual Animal Pup Clinical Observations Data (282KB)
- Individual Animal Pup Necropsy Data (5KB)
- Individual Animal Removal Reasons Data (7KB)
- Individual Animal Reproductive Performance Data (7KB)
RACB Study Tables
- F0 and F1c Parental Rats VagCyt Summary (213KB)
- F0 and F1 Rats VagCyt Trans Matrix (47KB)
- F0 and F1 Rats Vagcyt Plots (211KB)
- I01 - Animal Removal Summary (178KB)
- I02 - Animal Removals (5MB)
- I03 - Growth Curve (788KB)
- I04 - Mean Body Weight Summary (1MB)
- I04G - Mean Body Weight Gain (342KB)
- I05 - Clinical Observations Summary (2MB)
- I05P - Pup Clinical Observations Summary (942KB)
- I06 - Mean Feed Consumption (777KB)
- I08 - Mean Test Compound Consumption (578KB)
- I23 - Average Dose by Phase (81KB)
- PA02R - Neoplastic Lesion Summary with Percent and Litter Incidence (778KB)
- PA03R - Non-Neoplastic Lesion Summary with Percent and Litter Incidence (942KB)
- PA05R - Incidence Rates of Neoplastic Lesions with Litter Incidence Systemic Lesions Abridged (769KB)
- PA06R - Organ Weights Summary (245KB)
- PA08R - Statistical Analysis of Neoplastic Lesions with Litter Incidence (629KB)
- PA10R - Statistical Analysis of Non-Neoplastic Lesions with Litter Incidence (894KB)
- PA11 - Statistical Analysis of Survival Data (420KB)
- PA14 - Individual Animal Pathology Data (9MB)
- PA18R - Non-Neoplastic Lesion Summary with Severity Grade and Litter Incidence (943KB)
- PA23 - Ovarian Follicles Summary (93KB)
- PA40 - Survival Curve (1MB)
- PA46R - Summary of Gross Pathology with Litter Incidence (1MB)
- R01 - Multigeneration Cross Reference (12MB)
- R02 - Reproductive Performance Summary (148KB)
- R03 - Litter Data Summary (219KB)
- R04 - Anogenital Distance Summary (123KB)
- R06 - Andrology Summary (102KB)
- R14 - Developmental_Markers_Summary (141KB)
- R16 - Pubertal_Markers_Summary (156KB)
- R19 - Pup Mean Body Weight Summary (674KB)
- R19G - Pup Mean Body Weight Gain (472KB)
- R20 - Pup Necropsy Summary (702KB)
- R21 - Cross Generational Summary of Reproductive Performance (62KB)
- R22 - Cross Generational Summary of Litters (70KB)
RACB Individual Animal Data
- Individual Animal Andrology Data (35KB)
- Individual Animal Body Weight Data (1MB)
- Individual Animal Clinical Observations Data (4MB)
- Individual Animal Consumption Data (1MB)
- Individual Animal Developmental Markers Data (396KB)
- Individual Animal Gross Pathology Data (534KB)
- Individual Animal Histo Pathology Data (329KB)
- Individual Animal Litter Crossover Data (20KB)
- Individual Animal Litter Data (307KB)
- Individual Animal Organ Weight Data (91KB)
- Individual Animal Pup Body Weight Data (698KB)
- Individual Animal Pup Clinical Observations Data (3MB)
- Individual Animal Pup Necropsy Data (42KB)
- Individual Animal Removal Reasons Data (55KB)
- Individual Animal Reproductive Performance Crossover Data (9KB)
- Individual Animal Reproductive Performance Data (29KB)