Disposition and Metabolism of 2',2'''-Dithiobisbenzanilide in Rodents following Intravenous and Gavage Administration and Dermal Application

C. Edwin Garner, Christopher J. Wegerski, Joseph Lucak, Melanie Doyle-Eisele, Jacob D. McDonald, J. Michael Sanders, Benjamin C. Moeller and Suramya Waidyanatha

Radiolabel Description:
Carbon-14 uniformly on the rings; 2',2'''-Dithiobisbenzanilide, [phenyl-¹⁴C(U)]-

Vehicles:
Intravenous, emulphor:ethanol:water (3:5:2) or dimethylacetamide:polyethylene glycol 400:saline (15:55:30); Oral methylcellulose; Dermal, ethanol or acetone

Additional Information:
Two different vehicles were used for the rat 4 mg/kg intravenous treatments. Study C used water:ethanol:alkamuls (3:5:2) vehicle and Study C-2, dimethylacetamide:PEG400:saline (15:40:45).

ADME Data

Data Summary - Male Rats

• Dermal Single Dose Group E (0.4 mg/kg Study Duration 72 hours) (49KB)
• Dermal Single Dose Group M-A (4 mg/kg Study Duration 72 hours) (48KB)
• Gavage Single Dose Group A (40 mg/kg Study Duration 24 hours) (51KB)
• Gavage Single Dose Group G (4 mg/kg Study Duration 24 hours) (47KB)
• Gavage Single Dose Group H (400 mg/kg Study Duration 24 hours) (47KB)
• Gavage Single Dose Group I (400 mg/kg Study Duration 72 hours) (49KB)
• IV Single Dose Group C-2 (4 mg/kg, Study Duration 24 hours) (48KB)
• IV Single Dose Group Q (4 mg/kg, Study Duration 24 hours) (66KB)

Data Summary - Female Rats

• Gavage Single Dose Group O (40 mg/kg Study Duration 24 hours) (47KB)

Data Summary - Male Mice

• Dermal Single Dose Group F (0.4 mg/kg Study Duration 72 hours) (50KB)
• Dermal Single Dose Group N-A (4 mg/kg Study Duration 72 hours) (49KB)
• Gavage Single Dose Group B (40 mg/kg Study Duration 24 hours) (48KB)
• Gavage Single Dose Group J (4 mg/kg Study Duration 24 hours) (47KB)
• Gavage Single Dose Group L (400 mg/kg Study Duration 24 hours) (48KB)
• IV Single Dose Group D (4 mg/kg Study Duration 24 hours) (48KB)

Data Summary - Female Mice

• Gavage Single Dose Group P (40 mg/kg Study Duration 24 hours) (47KB)