Disposition and metabolism of antibacterial agent, Triclocarban; a species and route comparison

Suramya Waidyanatha, Sherry R. Black, Purvi R. Patel, Jason Stanko, Scott L. Watson, Rodney W. Snyder, and Timothy R. Fennell

https://doi.org/10.22427/NTP-DATA-002-02949-0005-0000-1

Radiolabel Description:
Carbon-14 in the phenyl ring with one chloride; Triclocarban, [Chlorophenyl ring-¹⁴C(U)]-

Vehicles:
Oral, corn oil; Dermal, acetone.

ADME Data

Data Summary - Male Rats

• Dermal Single Dose Group 10 (1.5%, 7.5 mg/kg,Covered, Study Duration 72 hours) (62KB)
• Dermal Single Dose Group 14 (3 %, 15 mg/kg, Study Duration 72 hours) (68KB)
• Dermal Single Dose Group 9 (3 %, 15 mg/kg, Covered, Study Duration 72 hours) (68KB)
• Gavage Single Dose Group 1 (500 mg/kg, Study Duration 72 hours) (69KB)
• Gavage Single Dose Group 2 (150 mg/kg, Study Duration 72 hours) (67KB)
• Gavage Single Dose Group 3 (50 mg/kg, Study Duration 72 hours) (82KB)
• Gavage Single Dose Group 4 (50 mg/kg, Study Duration 24 hours) (56KB)
• Gavage Single Dose Group 5 (50 mg/kg, Study Duration 48 hours) (51KB)

Data Summary - Female Rats

• Dermal Single Dose Group 11 (1.5%, 7.5 mg/kg, Covered, Study Duration 72 hours (62KB)
• Gavage Single Dose Group 6 (50 mg/kg, Study Duration 72 hours) (73KB)

Data Summary - Male Mice

• Dermal Single Dose Group 12 (1.5%, 18.75 mg/kg, Covered, Study Duration 72 hours) (78KB)
• Gavage Single Dose Group 7 (50 mg/kg, Study Duration 72 hours) (88KB)

Data Summary - Female Mice

• Dermal Single Dose Group 13 (1.5%, 18.75 mg/kg, Covered, Study Duration 72 hours) (77KB)
• Gavage Single Dose Group 7 (50 mg/kg, Study Duration 72 hours) (70KB)