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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Dibutyl Phthalate
CASRN: ="84-74-2"
Study Number: C10987
Exposure Route: DOSED FEED
TDMS Number: 1098702
Sex: Female
Strain and Species: B6C3F1/N Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
209 Vehicle Control Thin 04/02/2012 08/16/10 596.00 No
209 Vehicle Control Mass Torso/Dorsal, Large (16mm And Larger) 1 04/02/2012 08/16/10 596.00 No
209 Vehicle Control Thin 04/03/2012 08/16/10 597.00 Yes
209 Vehicle Control Mass Torso/Dorsal, Large (16mm And Larger) 1 04/03/2012 08/16/10 597.00 Yes
211 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 05/28/2012 08/16/10 652.00 No
211 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 06/25/2012 08/16/10 680.00 No
211 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 07/23/2012 08/16/10 708.00 No
211 Vehicle Control Eye Abnormality 07/23/2012 08/16/10 708.00 No
211 Vehicle Control Eye Abnormality 08/14/2012 08/16/10 730.00 Yes
211 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 08/14/2012 08/16/10 730.00 Yes
214 Vehicle Control Thin 08/14/2012 08/16/10 730.00 Yes
228 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 08/15/2012 08/16/10 731.00 Yes
229 Vehicle Control Thin 02/06/2012 08/16/10 540.00 No
229 Vehicle Control Thin 02/07/2012 08/16/10 541.00 Yes
235 Vehicle Control Mass Torso/Lateral, Medium (6mm-15mm) 1 05/28/2012 08/16/10 652.00 No
235 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 06/25/2012 08/16/10 680.00 No
235 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/23/2012 08/16/10 708.00 No
235 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 08/13/2012 08/16/10 729.00 Yes
243 Vehicle Control Thin 04/02/2012 08/16/10 596.00 No
243 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 04/02/2012 08/16/10 596.00 No
243 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 04/27/2012 08/16/10 621.00 Yes
243 Vehicle Control Ruffled Fur 04/27/2012 08/16/10 621.00 Yes
243 Vehicle Control Thin 04/27/2012 08/16/10 621.00 Yes
246 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 07/23/2012 08/16/10 708.00 No
246 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 07/29/2012 08/16/10 714.00 Yes
252 1000 ppm Abnormal Breathing 07/29/2012 08/16/10 714.00 Yes
252 1000 ppm Lethargic 07/29/2012 08/16/10 714.00 Yes
254 1000 ppm Eye Abnormality 05/28/2012 08/16/10 652.00 No
254 1000 ppm Mass Head, Small (1mm-5mm) 1 05/28/2012 08/16/10 652.00 No
254 1000 ppm Mass Head, Medium (6mm-15mm) 1 06/25/2012 08/16/10 680.00 No
254 1000 ppm Eye Abnormality 06/25/2012 08/16/10 680.00 No
254 1000 ppm Mass Head, Medium (6mm-15mm) 1 07/23/2012 08/16/10 708.00 No
254 1000 ppm Eye Abnormality 07/23/2012 08/16/10 708.00 No
254 1000 ppm Mass Head, Medium (6mm-15mm) 1 08/13/2012 08/16/10 729.00 Yes
254 1000 ppm Eye Abnormality 08/13/2012 08/16/10 729.00 Yes
261 1000 ppm Mass Torso/Ventral, Medium (6mm-15mm) 1 01/09/2012 08/16/10 512.00 No
261 1000 ppm Mass Torso/Ventral, Large (16mm And Larger) 1 02/06/2012 08/16/10 540.00 No
261 1000 ppm Mass Torso/Ventral, Large (16mm And Larger) 1 03/05/2012 08/16/10 568.00 No
261 1000 ppm Mass Torso/Ventral, Large (16mm And Larger) 1 03/23/2012 08/16/10 586.00 Yes
261 1000 ppm Thin 03/23/2012 08/16/10 586.00 Yes
265 1000 ppm Eye Abnormality 12/12/2011 08/16/10 484.00 No
265 1000 ppm Eye Abnormality 01/09/2012 08/16/10 512.00 No
265 1000 ppm Eye Abnormality 02/06/2012 08/16/10 540.00 No
265 1000 ppm Mass Head, Medium (6mm-15mm) 1 02/06/2012 08/16/10 540.00 No
265 1000 ppm Mass Head, Medium (6mm-15mm) 1 03/05/2012 08/16/10 568.00 No
265 1000 ppm Eye Abnormality 03/05/2012 08/16/10 568.00 No
265 1000 ppm Eye Abnormality 04/02/2012 08/16/10 596.00 No
265 1000 ppm Mass Head, Medium (6mm-15mm) 1 04/02/2012 08/16/10 596.00 No
265 1000 ppm Eye Abnormality 04/30/2012 08/16/10 624.00 No
265 1000 ppm Mass Head, Medium (6mm-15mm) 1 04/30/2012 08/16/10 624.00 No
265 1000 ppm Eye Abnormality 05/28/2012 08/16/10 652.00 No
265 1000 ppm Mass Torso/Dorsal, Medium (6mm-15mm) 1 05/28/2012 08/16/10 652.00 No
265 1000 ppm Mass Head, Small (1mm-5mm) 1 05/28/2012 08/16/10 652.00 No
265 1000 ppm Mass Torso/Dorsal, Medium (6mm-15mm) 1 06/24/2012 08/16/10 679.00 Yes
265 1000 ppm Mass Head, Small (1mm-5mm) 1 06/24/2012 08/16/10 679.00 Yes
268 1000 ppm Thin 08/14/2012 08/16/10 730.00 Yes
272 1000 ppm Mass Appendage, Small (1mm-5mm) 1 05/28/2012 08/16/10 652.00 No
272 1000 ppm Mass Appendage, Small (1mm-5mm) 1 06/25/2012 08/16/10 680.00 No
272 1000 ppm Mass Appendage, Small (1mm-5mm) 1 07/23/2012 08/16/10 708.00 No
272 1000 ppm Mass Appendage, Small (1mm-5mm) 1 08/13/2012 08/16/10 729.00 Yes
274 1000 ppm Ruffled Fur 07/23/2012 08/16/10 708.00 No
274 1000 ppm Ruffled Fur 08/13/2012 08/16/10 729.00 Yes
274 1000 ppm Lethargic 08/13/2012 08/16/10 729.00 Yes
274 1000 ppm Thin 08/13/2012 08/16/10 729.00 Yes
281 1000 ppm Eye Abnormality 05/28/2012 08/16/10 652.00 No
281 1000 ppm Eye Abnormality 06/25/2012 08/16/10 680.00 No
281 1000 ppm Mass Head, Small (1mm-5mm) 1 06/25/2012 08/16/10 680.00 No
281 1000 ppm Eye Abnormality 07/23/2012 08/16/10 708.00 No
281 1000 ppm Mass Head, Small (1mm-5mm) 1 07/23/2012 08/16/10 708.00 No
281 1000 ppm Eye Abnormality 08/13/2012 08/16/10 729.00 Yes
281 1000 ppm Mass Head, Small (1mm-5mm) 1 08/13/2012 08/16/10 729.00 Yes
293 1000 ppm Mass Torso/Ventral, Medium (6mm-15mm) 1 08/14/2012 08/16/10 730.00 Yes
297 1000 ppm Mass Appendage, Large (16mm And Larger) 1 01/09/2012 08/16/10 512.00 No
297 1000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 02/06/2012 08/16/10 540.00 No
297 1000 ppm Thin 03/05/2012 08/16/10 568.00 No
297 1000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 03/05/2012 08/16/10 568.00 No
297 1000 ppm Thin 03/14/2012 08/16/10 577.00 Yes
297 1000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 03/14/2012 08/16/10 577.00 Yes
300 1000 ppm Eye Abnormality 07/23/2012 08/16/10 708.00 No
300 1000 ppm Mass Head, Small (1mm-5mm) 1 08/14/2012 08/16/10 730.00 Yes
300 1000 ppm Eye Abnormality 08/14/2012 08/16/10 730.00 Yes
303 3000 ppm Mass Torso/Ventral, Medium (6mm-15mm) 1 08/13/2012 08/16/10 729.00 Yes
304 3000 ppm Thin 06/25/2012 08/16/10 680.00 No
307 3000 ppm Ruffled Fur 02/06/2012 08/16/10 540.00 No
307 3000 ppm Ruffled Fur 03/05/2012 08/16/10 568.00 No
307 3000 ppm Ruffled Fur 04/02/2012 08/16/10 596.00 No
307 3000 ppm Ruffled Fur 04/30/2012 08/16/10 624.00 No
307 3000 ppm Ruffled Fur 06/25/2012 08/16/10 680.00 No
332 3000 ppm Thin 03/26/2012 08/16/10 589.00 Yes
332 3000 ppm Mass Torso/Ventral, Large (16mm And Larger) 1 03/26/2012 08/16/10 589.00 Yes
334 3000 ppm Mass Torso/Lateral, Medium (6mm-15mm) 1 01/09/2012 08/16/10 512.00 No
334 3000 ppm Mass Torso/Lateral, Medium (6mm-15mm) 1 02/06/2012 08/16/10 540.00 No
334 3000 ppm Mass Torso/Dorsal, Medium (6mm-15mm) 1 03/05/2012 08/16/10 568.00 No
336 3000 ppm Mass Head, Small (1mm-5mm) 1 08/14/2012 08/16/10 730.00 Yes
343 3000 ppm Thin 07/23/2012 08/16/10 708.00 No
343 3000 ppm Thin 08/08/2012 08/16/10 724.00 Yes
348 3000 ppm Thin 08/14/2012 08/16/10 730.00 Yes
369 10000 ppm Ruffled Fur 05/28/2012 08/16/10 652.00 No
377 10000 ppm Mass Torso/Dorsal, Large (16mm And Larger) 1 06/25/2012 08/16/10 680.00 No
377 10000 ppm Mass Torso/Dorsal, Large (16mm And Larger) 1 07/23/2012 08/16/10 708.00 Yes
395 10000 ppm Mass Torso/Lateral, Medium (6mm-15mm) 1 04/02/2012 08/16/10 596.00 No
395 10000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 04/30/2012 08/16/10 624.00 No
395 10000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 05/28/2012 08/16/10 652.00 No
395 10000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 06/25/2012 08/16/10 680.00 No
395 10000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 07/23/2012 08/16/10 708.00 No
395 10000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 08/14/2012 08/16/10 730.00 Yes