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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Dibutyl Phthalate
CASRN: ="84-74-2"
Study Number: C10987
Exposure Route: DOSED FEED
TDMS Number: 1098702
Sex: Male
Strain and Species: B6C3F1/N Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
2 Vehicle Control Ruffled Fur 12/21/2011 08/17/10 492.00 Yes
2 Vehicle Control Lethargic 12/21/2011 08/17/10 492.00 Yes
4 Vehicle Control Thin 07/24/2012 08/17/10 708.00 No
4 Vehicle Control Thin 08/03/2012 08/17/10 718.00 Yes
5 Vehicle Control Thin 10/19/2010 08/17/10 64.00 No
5 Vehicle Control Ruffled Fur 11/15/2011 08/17/10 456.00 No
12 Vehicle Control Clonic Seizures 11/15/2011 08/17/10 456.00 No
12 Vehicle Control Lethargic 07/10/2012 08/17/10 694.00 Yes
13 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 05/29/2012 08/17/10 652.00 No
26 Vehicle Control Ruffled Fur 08/16/2012 08/17/10 731.00 Yes
40 Vehicle Control Tonic Seizures 12/13/2011 08/17/10 484.00 No
48 Vehicle Control Eye Abnormality 04/03/2012 08/17/10 596.00 No
48 Vehicle Control Eye Abnormality 05/01/2012 08/17/10 624.00 No
48 Vehicle Control Eye Abnormality 05/29/2012 08/17/10 652.00 No
48 Vehicle Control Eye Abnormality 06/26/2012 08/17/10 680.00 No
48 Vehicle Control Mass Head, Medium (6mm-15mm) 1 06/26/2012 08/17/10 680.00 No
48 Vehicle Control Mass Head, Medium (6mm-15mm) 1 07/24/2012 08/17/10 708.00 No
48 Vehicle Control Eye Abnormality 07/24/2012 08/17/10 708.00 No
48 Vehicle Control Eye Abnormality 08/16/2012 08/17/10 731.00 Yes
48 Vehicle Control Mass Head, Medium (6mm-15mm) 1 08/16/2012 08/17/10 731.00 Yes
50 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 04/03/2012 08/17/10 596.00 No
50 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 05/01/2012 08/17/10 624.00 No
50 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 05/29/2012 08/17/10 652.00 No
50 Vehicle Control Thin 08/17/2012 08/17/10 732.00 Yes
50 Vehicle Control Ruffled Fur 08/17/2012 08/17/10 732.00 Yes
54 1000 ppm Nasal/Eye Discharge 05/01/2012 08/17/10 624.00 No
54 1000 ppm Thin 07/24/2012 08/17/10 708.00 No
54 1000 ppm Eye Abnormality 07/24/2012 08/17/10 708.00 No
54 1000 ppm Thin 08/16/2012 08/17/10 731.00 Yes
54 1000 ppm Ruffled Fur 08/16/2012 08/17/10 731.00 Yes
54 1000 ppm Eye Abnormality 08/16/2012 08/17/10 731.00 Yes
55 1000 ppm Mass Torso/Ventral, Large (16mm And Larger) 1 07/15/2012 08/17/10 699.00 Yes
59 1000 ppm Ruffled Fur 04/03/2012 08/17/10 596.00 No
59 1000 ppm Eye Abnormality 04/03/2012 08/17/10 596.00 No
59 1000 ppm Eye Abnormality 05/01/2012 08/17/10 624.00 No
59 1000 ppm Nasal/Eye Discharge 05/01/2012 08/17/10 624.00 No
59 1000 ppm Eye Abnormality 05/29/2012 08/17/10 652.00 No
59 1000 ppm Mass Head, Medium (6mm-15mm) 1 06/26/2012 08/17/10 680.00 No
59 1000 ppm Eye Abnormality 06/26/2012 08/17/10 680.00 No
59 1000 ppm Eye Abnormality 07/24/2012 08/17/10 708.00 No
59 1000 ppm Mass Head, Medium (6mm-15mm) 1 07/24/2012 08/17/10 708.00 No
59 1000 ppm Eye Abnormality 08/17/2012 08/17/10 732.00 Yes
59 1000 ppm Ruffled Fur 08/17/2012 08/17/10 732.00 Yes
59 1000 ppm Mass Head, Medium (6mm-15mm) 1 08/17/2012 08/17/10 732.00 Yes
68 1000 ppm Thin 10/19/2010 08/17/10 64.00 No
73 1000 ppm Eye Abnormality 07/24/2012 08/17/10 708.00 No
73 1000 ppm Eye Abnormality 08/17/2012 08/17/10 732.00 Yes
75 1000 ppm Lethargic 07/17/2012 08/17/10 701.00 Yes
76 1000 ppm Ruffled Fur 07/24/2012 08/17/10 708.00 No
76 1000 ppm Thin 07/24/2012 08/17/10 708.00 No
76 1000 ppm Ruffled Fur 08/08/2012 08/17/10 723.00 Yes
76 1000 ppm Lethargic 08/08/2012 08/17/10 723.00 Yes
76 1000 ppm Abnormal Breathing 08/08/2012 08/17/10 723.00 Yes
76 1000 ppm Thin 08/08/2012 08/17/10 723.00 Yes
84 1000 ppm Thin 06/19/2012 08/17/10 673.00 Yes
85 1000 ppm Thin 11/15/2011 08/17/10 456.00 No
87 1000 ppm Ruffled Fur 08/17/2012 08/17/10 732.00 Yes
93 1000 ppm Mass Torso/Lateral, Medium (6mm-15mm) 1 05/03/2011 08/17/10 260.00 No
93 1000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 05/31/2011 08/17/10 288.00 No
93 1000 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 06/19/2011 08/17/10 307.00 Yes
107 3000 ppm Ruffled Fur 11/15/2011 08/17/10 456.00 No
116 3000 ppm Ruffled Fur 12/13/2011 08/17/10 484.00 No
116 3000 ppm Mass Torso/Ventral, Small (1mm-5mm) 1 05/01/2012 08/17/10 624.00 No
116 3000 ppm Thin 08/13/2012 08/17/10 728.00 Yes
116 3000 ppm Abnormal Breathing 08/13/2012 08/17/10 728.00 Yes
116 3000 ppm Lethargic 08/13/2012 08/17/10 728.00 Yes
122 3000 ppm Ruffled Fur 05/29/2012 08/17/10 652.00 No
122 3000 ppm Ruffled Fur 06/05/2012 08/17/10 659.00 Yes
123 3000 ppm Nasal/Eye Discharge 01/02/2012 08/17/10 504.00 Yes
123 3000 ppm Eye Abnormality 01/02/2012 08/17/10 504.00 Yes
123 3000 ppm Mass Head, Medium (6mm-15mm) 1 01/02/2012 08/17/10 504.00 Yes
128 3000 ppm Ruffled Fur 05/29/2012 08/17/10 652.00 No
128 3000 ppm Thin 06/26/2012 08/17/10 680.00 No
128 3000 ppm Mass Torso/Ventral, Large (16mm And Larger) 1 06/26/2012 08/17/10 680.00 No
128 3000 ppm Mass Torso/Ventral, Large (16mm And Larger) 1 07/24/2012 08/17/10 708.00 No
128 3000 ppm Thin 07/24/2012 08/17/10 708.00 No
128 3000 ppm Lethargic 08/14/2012 08/17/10 729.00 Yes
128 3000 ppm Abnormal Breathing 08/14/2012 08/17/10 729.00 Yes
128 3000 ppm Thin 08/14/2012 08/17/10 729.00 Yes
132 3000 ppm Ruffled Fur 05/29/2012 08/17/10 652.00 No
132 3000 ppm Ruffled Fur 06/05/2012 08/17/10 659.00 Yes
140 3000 ppm Ruffled Fur 04/03/2012 08/17/10 596.00 No
154 10000 ppm Ruffled Fur 11/16/2010 08/17/10 92.00 No
154 10000 ppm Thin 11/16/2010 08/17/10 92.00 No
154 10000 ppm Thin 05/03/2011 08/17/10 260.00 No
154 10000 ppm Ruffled Fur 09/20/2011 08/17/10 400.00 Yes
154 10000 ppm Thin 09/20/2011 08/17/10 400.00 Yes
154 10000 ppm Thin 09/20/2011 08/17/10 400.00 No
154 10000 ppm Ruffled Fur 09/20/2011 08/17/10 400.00 No
155 10000 ppm Thin 11/16/2010 08/17/10 92.00 No
159 10000 ppm Thin 04/03/2012 08/17/10 596.00 No
159 10000 ppm Ruffled Fur 04/03/2012 08/17/10 596.00 No
165 10000 ppm Nasal/Eye Discharge 05/01/2012 08/17/10 624.00 Yes
168 10000 ppm Ruffled Fur 12/13/2011 08/17/10 484.00 No
174 10000 ppm Thin 10/19/2010 08/17/10 64.00 No
174 10000 ppm Ruffled Fur 10/19/2010 08/17/10 64.00 No
175 10000 ppm Thin 10/19/2010 08/17/10 64.00 No
175 10000 ppm Ruffled Fur 10/19/2010 08/17/10 64.00 No
175 10000 ppm Ruffled Fur 05/01/2012 08/17/10 624.00 Yes
175 10000 ppm Thin 05/01/2012 08/17/10 624.00 No
175 10000 ppm Ruffled Fur 05/01/2012 08/17/10 624.00 No
175 10000 ppm Lethargic 05/01/2012 08/17/10 624.00 No
175 10000 ppm Lethargic 05/01/2012 08/17/10 624.00 Yes
175 10000 ppm Thin 05/01/2012 08/17/10 624.00 Yes
176 10000 ppm Mass Head, Medium (6mm-15mm) 1 06/26/2012 08/17/10 680.00 No
176 10000 ppm Mass Head, Medium (6mm-15mm) 1 07/24/2012 08/17/10 708.00 No
176 10000 ppm Mass Head, Medium (6mm-15mm) 1 08/17/2012 08/17/10 732.00 Yes
185 10000 ppm Ruffled Fur 05/03/2011 08/17/10 260.00 No
191 10000 ppm Thin 11/16/2010 08/17/10 92.00 No
194 10000 ppm Mass Head, Small (1mm-5mm) 1 07/24/2012 08/17/10 708.00 No
194 10000 ppm Mass Head, Small (1mm-5mm) 1 08/16/2012 08/17/10 731.00 Yes
195 10000 ppm Ruffled Fur 08/16/2012 08/17/10 731.00 Yes
196 10000 ppm Nasal/Eye Discharge 06/26/2012 08/17/10 680.00 Yes