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Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Perfluorooctanoic Acid
CASRN: ="335-67-1"
Study Number: C20614
Exposure Route: DOSED FEED
TDMS Number: 2061401
Sex: Male
Strain and Species: HSD Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Bile Duct 300 ppm 10 103 205 109 1 Hyperplasia Minimal Scheduled Sacrifice
Alimentary System Liver Bile Duct 300 ppm 10 126 251 109 1 Hyperplasia Minimal Scheduled Sacrifice
Alimentary System Liver Bile Duct 300 ppm 10 139 278 109 1 Hyperplasia Minimal Scheduled Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 300 ppm 10 101 202 109 1 Hypertrophy Moderate Scheduled Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 300 ppm 10 103 206 109 1 Hypertrophy Moderate Scheduled Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 300 ppm 10 107 214 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 300 ppm 10 99 198 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 31 62 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 37 73 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 40 79 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 40 80 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 41 81 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 41 82 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 42 83 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 46 91 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 56 111 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 56 112 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 61 121 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 65 129 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 68 136 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 70 139 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 70 140 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 74 147 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 77 153 109 1 Cytoplasmic Alteration Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 77 154 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 81 161 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 84 167 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 101 202 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 103 205 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 103 206 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 107 214 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 108 216 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 113 226 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 114 227 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 114 228 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 123 245 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 126 251 109 1 Cytoplasmic Alteration Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 133 265 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 134 267 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 134 268 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 139 277 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 139 278 109 1 Cytoplasmic Alteration Marked Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 140 279 109 1 Cytoplasmic Alteration Marked Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 140 280 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 141 282 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 93 185 109 1 Cytoplasmic Alteration Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 99 198 109 1 Cytoplasmic Alteration Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 31 62 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 37 73 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 40 79 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 40 80 109 1 Hypertrophy Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 41 81 109 1 Hypertrophy Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 41 82 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 42 83 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 46 91 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 56 111 109 1 Hypertrophy Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 56 112 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 61 121 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 65 129 109 1 Hypertrophy Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 68 136 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 70 139 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 70 140 109 1 Hypertrophy Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 74 147 109 1 Hypertrophy Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 77 153 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 77 154 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 81 161 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 84 167 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 103 205 109 1 Hypertrophy Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 108 216 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 113 226 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 114 227 109 1 Hypertrophy Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 114 228 109 1 Hypertrophy Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 123 245 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 126 251 109 1 Hypertrophy Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 133 265 109 1 Hypertrophy Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 134 267 109 1 Hypertrophy Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 134 268 109 1 Hypertrophy Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 139 277 109 1 Hypertrophy Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 139 278 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 140 279 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 140 280 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 141 282 109 1 Hypertrophy Moderate Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 93 185 109 1 Hypertrophy Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 31 62 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 37 73 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 40 79 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 40 80 109 1 Single Cell Death Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 41 81 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 41 82 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 42 83 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 46 91 109 1 Single Cell Death Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 56 111 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 56 112 109 1 Single Cell Death Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 61 121 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 65 129 109 1 Single Cell Death Mild Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 68 136 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 70 139 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 70 140 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 74 147 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 77 154 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 81 161 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 150 ppm 10 84 167 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 101 202 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 103 205 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 103 206 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 107 214 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 108 216 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 113 226 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 114 227 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 114 228 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 123 245 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 126 251 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 133 265 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 134 267 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 134 268 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 139 277 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 139 278 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 140 279 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 140 280 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 141 282 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 93 185 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver Hepatocyte 300 ppm 10 99 198 109 1 Single Cell Death Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 42 83 109 1 Clear Cell Focus Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 126 251 109 1 Clear Cell Focus Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 141 282 109 1 Clear Cell Focus Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 31 62 109 1 Extramedullary Hematopoiesis Minimal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 140 279 109 1 Fibrosis Minimal, Focal Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 11 22 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 12 23 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 12 24 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 15 29 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 22 43 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 23 46 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 5 10 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver Vehicle Control 10 8 15 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 31 62 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 37 73 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 40 79 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 40 80 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 41 81 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 41 82 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 42 83 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 46 91 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 56 112 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 61 121 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 68 136 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 70 139 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 70 140 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 74 147 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 77 153 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 77 154 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 81 161 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 84 167 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 101 202 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 103 205 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 107 214 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 108 216 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 113 226 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 114 227 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 114 228 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 123 245 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 126 251 109 1 Inflammation Mild, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 133 265 109 1 Inflammation Mild, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 134 267 109 1 Inflammation Mild, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 134 268 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 139 277 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 139 278 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 140 280 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 99 198 109 1 Inflammation Minimal, Focal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 40 79 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 40 80 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 41 81 109 1 Necrosis Mild Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 42 83 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 46 91 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 56 112 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 61 121 109 1 Necrosis Mild Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 70 139 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 108 216 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 113 226 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 126 251 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 134 268 109 1 Necrosis Marked Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 139 278 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 140 279 109 1 Necrosis Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 31 62 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 37 73 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 40 79 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 40 80 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 41 81 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 41 82 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 42 83 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 56 111 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 61 121 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 65 129 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 70 139 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 70 140 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 74 147 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 77 153 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 77 154 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 81 161 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 150 ppm 10 84 167 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 101 202 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 103 205 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 103 206 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 107 214 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 108 216 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 113 226 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 114 227 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 114 228 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 123 245 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 126 251 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 133 265 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 134 267 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 134 268 109 1 Pigment Moderate Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 139 277 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 139 278 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 140 279 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 140 280 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 141 282 109 1 Pigment Minimal Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 93 185 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Liver 300 ppm 10 99 198 109 1 Pigment Mild Scheduled Sacrifice
Alimentary System Stomach, Forestomach Epithelium 300 ppm 10 140 280 109 1 Hyperplasia Mild Scheduled Sacrifice
Alimentary System Stomach, Forestomach Epithelium 300 ppm 10 141 282 109 1 Hyperplasia Marked Scheduled Sacrifice
Alimentary System Stomach, Forestomach Submucosa 300 ppm 10 134 268 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Forestomach Submucosa 300 ppm 10 140 280 109 1 Inflammation Mild, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Forestomach Submucosa 300 ppm 10 141 282 109 1 Inflammation Mild, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Epithelium 300 ppm 10 114 228 109 1 Erosion Minimal Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 150 ppm 10 42 83 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 150 ppm 10 46 91 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 150 ppm 10 70 140 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 150 ppm 10 77 154 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 300 ppm 10 103 205 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 300 ppm 10 108 216 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 300 ppm 10 114 227 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 300 ppm 10 114 228 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 300 ppm 10 126 251 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 300 ppm 10 139 278 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Stomach, Glandular Submucosa 300 ppm 10 99 198 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Cardiovascular System Heart Vehicle Control 10 15 29 109 1 Cardiomyopathy Minimal Scheduled Sacrifice
Cardiovascular System Heart Vehicle Control 10 23 46 109 1 Cardiomyopathy Minimal Scheduled Sacrifice
Cardiovascular System Heart Vehicle Control 10 26 51 109 1 Cardiomyopathy Minimal Scheduled Sacrifice
Cardiovascular System Heart Vehicle Control 10 5 10 109 1 Cardiomyopathy Minimal Scheduled Sacrifice
Endocrine System Adrenal Cortex Vehicle Control 10 11 22 109 1 Hyperplasia Mild Scheduled Sacrifice
Endocrine System Adrenal Cortex Vehicle Control 10 12 23 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Adrenal Cortex Vehicle Control 10 15 29 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Adrenal Cortex 150 ppm 10 41 82 109 1 Hypertrophy Mild Scheduled Sacrifice
Endocrine System Adrenal Cortex 300 ppm 10 101 202 109 1 Vacuolization Cytoplasmic Minimal Scheduled Sacrifice
Endocrine System Parathyroid Gland 300 ppm 10 103 205 109 1 Atrophy Mild Scheduled Sacrifice
Endocrine System Pituitary Gland Pars Distalis 150 ppm 10 31 62 109 1 Cyst Scheduled Sacrifice
Endocrine System Pituitary Gland Rathkes Cleft 150 ppm 10 61 121 109 1 Hyperplasia Mild, Tubular Scheduled Sacrifice
Endocrine System Pituitary Gland 300 ppm 10 114 227 109 1 Cyst Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 150 ppm 10 40 79 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 150 ppm 10 40 80 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 300 ppm 10 101 202 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 300 ppm 10 103 206 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 300 ppm 10 108 216 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 300 ppm 10 113 226 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 300 ppm 10 126 251 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 300 ppm 10 134 267 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 300 ppm 10 93 185 109 1 Hypertrophy Minimal Scheduled Sacrifice
Endocrine System Thyroid Gland Follicular Cel 300 ppm 10 99 198 109 1 Hypertrophy Minimal Scheduled Sacrifice
Genital System Prostate 300 ppm 10 134 267 109 1 Hyperplasia Minimal Scheduled Sacrifice
Hematopoietic System Lymph Node Mandibular 150 ppm 10 41 81 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Lymph Node Mandibular 150 ppm 10 46 91 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Lymph Node Mandibular 150 ppm 10 77 154 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Lymph Node Mandibular 150 ppm 10 81 161 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Lymph Node Mandibular 300 ppm 10 141 282 109 1 Atrophy Mild Scheduled Sacrifice
Hematopoietic System Lymph Node Mandibular 300 ppm 10 93 185 109 1 Atrophy Mild Scheduled Sacrifice
Hematopoietic System Lymph Node Mesenteric 300 ppm 10 139 277 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Lymph Node Mesenteric 300 ppm 10 141 282 109 1 Atrophy Mild Scheduled Sacrifice
Hematopoietic System Lymph Node Mesenteric 300 ppm 10 93 185 109 1 Atrophy Moderate Scheduled Sacrifice
Hematopoietic System Spleen Lymph Follic 300 ppm 10 114 228 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Spleen Lymph Follic 300 ppm 10 140 279 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Spleen Lymph Follic 300 ppm 10 93 185 109 1 Atrophy Mild Scheduled Sacrifice
Hematopoietic System Spleen Lymph Follic 300 ppm 10 99 198 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Spleen 300 ppm 10 134 268 109 1 Extramedullary Hematopoiesis Minimal Scheduled Sacrifice
Hematopoietic System Spleen 300 ppm 10 139 278 109 1 Extramedullary Hematopoiesis Minimal Scheduled Sacrifice
Hematopoietic System Thymus Vehicle Control 10 26 51 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Thymus 300 ppm 10 103 205 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Thymus 300 ppm 10 108 216 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Thymus 300 ppm 10 126 251 109 1 Atrophy Minimal Scheduled Sacrifice
Hematopoietic System Thymus 300 ppm 10 140 280 109 1 Atrophy Mild Scheduled Sacrifice
Hematopoietic System Thymus 300 ppm 10 93 185 109 1 Atrophy Minimal Scheduled Sacrifice
Respiratory System Lung Alveolus 150 ppm 10 56 111 109 1 Infiltration Cellular Minimal, Histiocyte Scheduled Sacrifice
Respiratory System Lung Alveolus 150 ppm 10 84 167 109 1 Infiltration Cellular Minimal, Histiocyte Scheduled Sacrifice
Respiratory System Lung 150 ppm 10 40 80 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Respiratory System Lung 150 ppm 10 74 147 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Respiratory System Lung 300 ppm 10 99 198 109 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Urinary System Kidney Pelvis Vehicle Control 10 5 10 109 1 Dilation Minimal Scheduled Sacrifice
Urinary System Kidney Pelvis 150 ppm 10 70 139 109 1 Dilation Mild Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 139 278 109 1 Dilation Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 150 ppm 10 40 80 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 150 ppm 10 41 81 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 150 ppm 10 41 82 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 150 ppm 10 42 83 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 150 ppm 10 84 167 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 103 205 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 107 214 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 113 226 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 114 227 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 114 228 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 123 245 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 126 251 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 134 267 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 140 279 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 140 280 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Renal Tubule 300 ppm 10 141 282 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 12 24 109 1 Accumulation, Hyaline Droplet Minimal Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 23 46 109 1 Accumulation, Hyaline Droplet Minimal Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 108 216 109 1 Fibrosis Minimal, Focal Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 70 140 109 1 Mineral Minimal Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 11 22 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 12 23 109 1 Nephropathy Mild, Chronicprogr Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 12 24 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 15 29 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 22 43 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 22 44 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 23 46 109 1 Nephropathy Mild, Chronicprogr Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 26 51 109 1 Nephropathy Mild, Chronicprogr Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 5 10 109 1 Nephropathy Mild, Chronicprogr Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 8 15 109 1 Nephropathy Mild, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 31 62 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 40 79 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 42 83 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 56 112 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 65 129 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 68 136 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 70 140 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 74 147 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 77 153 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 77 154 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 150 ppm 10 81 161 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 103 205 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 113 226 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 114 228 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 123 245 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 133 265 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 139 278 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 140 279 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 141 282 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice
Urinary System Kidney 300 ppm 10 99 198 109 1 Nephropathy Minimal, Chronicprogr Scheduled Sacrifice