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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Sodium Tungstate Dihydrate
CASRN: ="10213-10-2"
Study Number: C03038
Exposure Route: DOSED WATER
TDMS Number: 0303804
Sex: Female
Strain and Species: B6C3F1/N Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
201 Vehicle Control Ruffled Fur 11/25/2013 01/16/12 680.00 No
201 Vehicle Control Abnormal Breathing 11/25/2013 01/16/12 680.00 No
201 Vehicle Control Thin 11/25/2013 01/16/12 680.00 No
201 Vehicle Control Ruffled Fur 12/17/2013 01/16/12 702.00 Yes
201 Vehicle Control Thin 12/17/2013 01/16/12 702.00 Yes
201 Vehicle Control Abnormal Breathing 12/17/2013 01/16/12 702.00 Yes
203 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 06/10/2013 01/16/12 512.00 No
203 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 07/08/2013 01/16/12 540.00 No
203 Vehicle Control Thin 07/28/2013 01/16/12 560.00 Yes
203 Vehicle Control Ruffled Fur 07/28/2013 01/16/12 560.00 Yes
203 Vehicle Control Lethargic 07/28/2013 01/16/12 560.00 Yes
203 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 07/28/2013 01/16/12 560.00 Yes
205 Vehicle Control Eye Abnormality 11/25/2013 01/16/12 680.00 No
205 Vehicle Control Eye Abnormality 12/23/2013 01/16/12 708.00 No
205 Vehicle Control Eye Abnormality 01/15/2014 01/16/12 731.00 Yes
225 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 07/08/2013 01/16/12 540.00 No
225 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 08/03/2013 01/16/12 566.00 Yes
235 Vehicle Control Thin 01/13/2014 01/16/12 729.00 Yes
235 Vehicle Control Abnormal Breathing 01/13/2014 01/16/12 729.00 Yes
249 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 01/15/2014 01/16/12 731.00 Yes
253 500 mg/L Head Tilt 09/30/2013 01/16/12 624.00 No
253 500 mg/L Head Tilt 10/03/2013 01/16/12 627.00 Yes
253 500 mg/L Thin 10/03/2013 01/16/12 627.00 Yes
257 500 mg/L Thin 06/10/2013 01/16/12 512.00 No
257 500 mg/L Thin 07/08/2013 01/16/12 540.00 No
257 500 mg/L Thin 08/05/2013 01/16/12 568.00 No
257 500 mg/L Ruffled Fur 09/02/2013 01/16/12 596.00 No
257 500 mg/L Thin 09/02/2013 01/16/12 596.00 No
257 500 mg/L Thin 09/05/2013 01/16/12 599.00 Yes
260 500 mg/L Thin 06/10/2013 01/16/12 512.00 No
260 500 mg/L Thin 07/08/2013 01/16/12 540.00 No
272 500 mg/L Mass Torso/Ventral, Large (16mm And Larger) 1 11/25/2013 01/16/12 680.00 No
272 500 mg/L Mass Torso/Ventral, Large (16mm And Larger) 1 12/03/2013 01/16/12 688.00 Yes
273 500 mg/L Mass Torso/Ventral, Large (16mm And Larger) 1 01/13/2014 01/16/12 729.00 Yes
276 500 mg/L Thin 11/25/2013 01/16/12 680.00 No
276 500 mg/L Mass Torso/Lateral, Medium (6mm-15mm) 1 12/23/2013 01/16/12 708.00 No
276 500 mg/L Thin 12/23/2013 01/16/12 708.00 No
276 500 mg/L Mass Torso/Ventral, Medium (6mm-15mm) 1 01/13/2014 01/16/12 729.00 Yes
276 500 mg/L Thin 01/13/2014 01/16/12 729.00 Yes
290 500 mg/L Eye Abnormality 09/02/2013 01/16/12 596.00 No
290 500 mg/L Eye Abnormality 09/30/2013 01/16/12 624.00 No
290 500 mg/L Eye Abnormality 10/28/2013 01/16/12 652.00 No
290 500 mg/L Eye Abnormality 11/25/2013 01/16/12 680.00 No
290 500 mg/L Eye Abnormality 12/23/2013 01/16/12 708.00 No
290 500 mg/L Eye Abnormality 01/14/2014 01/16/12 730.00 Yes
290 500 mg/L Mass Head, Small (1mm-5mm) 1 01/14/2014 01/16/12 730.00 Yes
293 500 mg/L Ulcer/Abscess Head 1 12/23/2013 01/16/12 708.00 No
293 500 mg/L Ulcer/Abscess Head 1 01/15/2014 01/16/12 731.00 Yes
293 500 mg/L Eye Abnormality 01/15/2014 01/16/12 731.00 Yes
293 500 mg/L Ulcer/Abscess Torso/Dorsal 1 01/15/2014 01/16/12 731.00 Yes
295 500 mg/L Mass Torso/Lateral, Large (16mm And Larger) 2 01/14/2014 01/16/12 730.00 Yes
298 500 mg/L Mass Torso/Dorsal, Medium (6mm-15mm) 2 01/15/2014 01/16/12 731.00 Yes
309 1000 mg/L Ruffled Fur 05/13/2013 01/16/12 484.00 No
309 1000 mg/L Mass Torso/Ventral, Medium (6mm-15mm) 1 07/08/2013 01/16/12 540.00 No
309 1000 mg/L Mass Torso/Ventral, Medium (6mm-15mm) 1 08/05/2013 01/16/12 568.00 No
309 1000 mg/L Mass Torso/Ventral, Medium (6mm-15mm) 1 09/02/2013 01/16/12 596.00 No
309 1000 mg/L Ruffled Fur 09/02/2013 01/16/12 596.00 No
309 1000 mg/L Thin 09/02/2013 01/16/12 596.00 No
309 1000 mg/L Mass Torso/Ventral, Medium (6mm-15mm) 1 09/10/2013 01/16/12 604.00 Yes
309 1000 mg/L Ruffled Fur 09/10/2013 01/16/12 604.00 Yes
309 1000 mg/L Thin 09/10/2013 01/16/12 604.00 Yes
309 1000 mg/L Ulcer/Abscess Torso/Ventral 1 09/10/2013 01/16/12 604.00 Yes
310 1000 mg/L Clonic Seizures 01/21/2013 01/16/12 372.00 No
310 1000 mg/L Tonic Seizures 01/21/2013 01/16/12 372.00 No
310 1000 mg/L Ruffled Fur 05/13/2013 01/16/12 484.00 No
311 1000 mg/L Mass Torso/Lateral, Large (16mm And Larger) 1 09/02/2013 01/16/12 596.00 No
311 1000 mg/L Mass Torso/Lateral, Large (16mm And Larger) 1 09/30/2013 01/16/12 624.00 No
311 1000 mg/L Mass Torso/Lateral, Medium (6mm-15mm) 1 10/28/2013 01/16/12 652.00 No
311 1000 mg/L Mass Torso/Lateral, Large (16mm And Larger) 1 10/28/2013 01/16/12 652.00 No
311 1000 mg/L Mass Torso/Lateral, Large (16mm And Larger) 1 11/25/2013 01/16/12 680.00 No
311 1000 mg/L Mass Torso/Lateral, Large (16mm And Larger) 1 12/23/2013 01/16/12 708.00 No
311 1000 mg/L Mass Torso/Lateral, Medium (6mm-15mm) 1 12/23/2013 01/16/12 708.00 No
311 1000 mg/L Mass Torso/Lateral, Large (16mm And Larger) 1 12/28/2013 01/16/12 713.00 Yes
311 1000 mg/L Mass Torso/Lateral, Medium (6mm-15mm) 1 12/28/2013 01/16/12 713.00 Yes
315 1000 mg/L Mass Torso/Lateral, Large (16mm And Larger) 1 12/23/2013 01/16/12 708.00 No
315 1000 mg/L Mass Torso/Lateral, Large (16mm And Larger) 1 01/14/2014 01/16/12 730.00 Yes
316 1000 mg/L Mass Torso/Lateral, Large (16mm And Larger) 1 10/28/2013 01/16/12 652.00 No
318 1000 mg/L Impaired Gait 12/26/2013 01/16/12 711.00 Yes
318 1000 mg/L Ataxia 12/26/2013 01/16/12 711.00 Yes
327 1000 mg/L Ruffled Fur 09/03/2012 01/16/12 232.00 No
327 1000 mg/L Thin 09/16/2012 01/16/12 245.00 Yes
327 1000 mg/L Ruffled Fur 09/16/2012 01/16/12 245.00 Yes
329 1000 mg/L Mass Appendage, Small (1mm-5mm) 1 11/26/2012 01/16/12 316.00 No
329 1000 mg/L Mass Appendage, Small (1mm-5mm) 1 12/24/2012 01/16/12 344.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 01/21/2013 01/16/12 372.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 02/18/2013 01/16/12 400.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 03/18/2013 01/16/12 428.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 05/13/2013 01/16/12 484.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 06/10/2013 01/16/12 512.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 07/08/2013 01/16/12 540.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 08/05/2013 01/16/12 568.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 09/02/2013 01/16/12 596.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 09/30/2013 01/16/12 624.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 10/28/2013 01/16/12 652.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 11/25/2013 01/16/12 680.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 12/23/2013 01/16/12 708.00 No
329 1000 mg/L Mass Appendage, Medium (6mm-15mm) 1 01/13/2014 01/16/12 729.00 Yes
334 1000 mg/L Thin 11/26/2012 01/16/12 316.00 No
334 1000 mg/L Thin 05/13/2013 01/16/12 484.00 No
334 1000 mg/L Thin 06/10/2013 01/16/12 512.00 No
334 1000 mg/L Thin 11/25/2013 01/16/12 680.00 No
334 1000 mg/L Thin 12/23/2013 01/16/12 708.00 No
334 1000 mg/L Thin 01/13/2014 01/16/12 729.00 Yes
338 1000 mg/L Eye Abnormality 12/23/2013 01/16/12 708.00 No
338 1000 mg/L Eye Abnormality 01/15/2014 01/16/12 731.00 Yes
356 2000 mg/L Ulcer/Abscess Torso/Lateral 1 12/23/2013 01/16/12 708.00 No
356 2000 mg/L Ulcer/Abscess Torso/Dorsal 3 01/06/2014 01/16/12 722.00 Yes
363 2000 mg/L Thin 10/28/2013 01/16/12 652.00 No
363 2000 mg/L Ruffled Fur 10/28/2013 01/16/12 652.00 No
370 2000 mg/L Mass Appendage, Small (1mm-5mm) 1 09/30/2013 01/16/12 624.00 No
370 2000 mg/L Mass Appendage, Small (1mm-5mm) 1 10/28/2013 01/16/12 652.00 No
370 2000 mg/L Mass Appendage, Small (1mm-5mm) 1 11/25/2013 01/16/12 680.00 No
370 2000 mg/L Mass Appendage, Small (1mm-5mm) 1 12/23/2013 01/16/12 708.00 No
370 2000 mg/L Mass Appendage, Small (1mm-5mm) 1 01/15/2014 01/16/12 731.00 Yes
371 2000 mg/L Head Tilt 01/15/2014 01/16/12 731.00 Yes
378 2000 mg/L Thin 12/23/2013 01/16/12 708.00 No
378 2000 mg/L Thin 01/05/2014 01/16/12 721.00 Yes
385 2000 mg/L Mass Appendage, Medium (6mm-15mm) 1 12/23/2013 01/16/12 708.00 No
385 2000 mg/L Mass Appendage, Large (16mm And Larger) 1 01/13/2014 01/16/12 729.00 Yes
388 2000 mg/L Thin 11/25/2013 01/16/12 680.00 No
388 2000 mg/L Thin 11/28/2013 01/16/12 683.00 Yes