If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Ionic Liquid: N-Butylpyridinium Chloride
CASRN: ="1124-64-7"
Study Number: C05052
Exposure Route: DOSED WATER
TDMS Number: 5005201
Sex: Male
Strain and Species: HSD Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Jejunum, Peyers Patch Vehicle Control 10 66 701 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Intestine Small Jejunum, Peyers Patch Vehicle Control 10 68 708 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Intestine Small Jejunum, Peyers Patch 1 mg/mL 1 77 730 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Intestine Small Jejunum, Peyers Patch 3 mg/mL 10 78 732 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Liver 3 mg/mL 10 81 740 92 1 Basophilic Focus Terminal Sacrifice
Alimentary System Liver 3 mg/mL 10 80 737 92 1 Eosinophilic Focus Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 69 710 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 3 mg/mL 10 79 734 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 68 707 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 66 703 92 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 67 706 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 68 708 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 69 709 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Stomach, Glandular Muscularis 3 mg/mL 10 78 733 92 1 Degeneration Minimal Terminal Sacrifice
Alimentary System Stomach, Glandular Vehicle Control 10 68 708 92 1 Mineralization Minimal Terminal Sacrifice
Alimentary System Stomach, Glandular Vehicle Control 10 69 710 92 1 Mineralization Minimal Terminal Sacrifice
Alimentary System Stomach, Glandular 3 mg/mL 10 79 736 92 1 Mineralization Minimal Terminal Sacrifice
Cardiovascular System Heart Valve Vehicle Control 10 67 705 92 1 Inflammation Minimal Terminal Sacrifice
Cardiovascular System Heart 3 mg/mL 10 79 735 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 3 mg/mL 10 81 739 6 1 Inflammation Minimal, Suppurative Natural Death
Endocrine System Thyroid Gland 3 mg/mL 10 81 739 6 1 Atrophy Mild Natural Death
Endocrine System Thyroid Gland 3 mg/mL 10 81 739 6 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Genital System Prostate 3 mg/mL 10 81 739 6 1 Atrophy Mild Natural Death
Genital System Prostate Vehicle Control 10 66 703 92 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Genital System Prostate 3 mg/mL 10 81 739 6 1 Inflammation Mild, Suppurative Natural Death
Genital System Testes 3 mg/mL 10 80 738 92 1 Degeneration Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 3 mg/mL 10 81 739 6 1 Hemorrhage Mild Natural Death
Hematopoietic System Bone Marrow 3 mg/mL 10 81 739 6 1 Necrosis Mild Natural Death
Hematopoietic System Lymph Node Mandibular 3 mg/mL 10 81 739 6 1 Necrosis Minimal, Lymphoid Natural Death
Hematopoietic System Spleen Vehicle Control 10 66 702 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 67 704 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 67 706 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 68 707 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 68 708 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 78 733 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 80 738 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 66 701 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 66 702 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 67 704 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 67 705 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 67 706 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 68 707 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 68 708 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 69 710 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 78 731 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 78 732 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 78 733 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 79 734 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 79 735 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 79 736 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 80 738 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 3 mg/mL 10 81 740 92 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Integumentary System Mammary Gland 3 mg/mL 10 79 734 92 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung 3 mg/mL 10 79 734 92 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 3 mg/mL 10 80 738 92 1 Metaplasia, Osseous Minimal, Osseous Terminal Sacrifice
Respiratory System Nose Olfactory Epi Vehicle Control 10 67 705 92 1 Accumulation, Hyaline Droplet Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi Vehicle Control 10 68 707 92 1 Accumulation, Hyaline Droplet Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi Vehicle Control 10 68 708 92 1 Accumulation, Hyaline Droplet Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi Vehicle Control 10 69 709 92 1 Accumulation, Hyaline Droplet Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi Vehicle Control 10 69 710 92 1 Accumulation, Hyaline Droplet Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 3 mg/mL 10 78 731 92 1 Accumulation, Hyaline Droplet Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 3 mg/mL 10 78 733 92 1 Accumulation, Hyaline Droplet Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 3 mg/mL 10 80 738 92 1 Accumulation, Hyaline Droplet Minimal Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 66 703 92 1 Inflammation Minimal Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 67 705 92 1 Inflammation Minimal Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 67 706 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Harderian Gland 3 mg/mL 10 81 740 92 1 Inflammation Minimal Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 81 739 6 1 Inflammation Minimal, Suppurative Natural Death
Urinary System Kidney Vehicle Control 10 66 703 92 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 66 701 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 66 702 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 66 703 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 67 704 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 67 705 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 67 706 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 68 707 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 68 708 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 69 709 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 69 710 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 78 731 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 78 732 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 78 733 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 79 734 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 79 735 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 79 736 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 80 737 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 80 738 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 mg/mL 10 81 740 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Urethra 3 mg/mL 1 81 739 6 1 Inflammation Marked, Suppurative Natural Death
Urinary System Urinary Bladder 3 mg/mL 10 81 739 6 1 Inflammation Minimal, Suppurative Natural Death