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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) |
CASRN: | ="21850-44-2" |
Study Number: | C20321 |
Exposure Route: | GAVAGE |
TDMS Number: | 2032101 |
Sex: | Female |
Strain and Species: | F344/N Tac Rats |
Female Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Intestine Large |
Rectum |
1000 mg/kg |
10 |
23 |
115 |
93 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
61 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
64 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
67 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
70 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
8 |
15 |
71 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
8 |
15 |
72 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
8 |
15 |
74 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
8 |
15 |
75 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
8 |
16 |
76 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
8 |
16 |
77 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
8 |
16 |
78 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
8 |
16 |
79 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
8 |
17 |
81 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
8 |
17 |
82 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
8 |
17 |
83 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
8 |
17 |
85 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
8 |
18 |
86 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
8 |
18 |
88 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
8 |
18 |
89 |
93 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
8 |
18 |
90 |
93 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
9 |
19 |
91 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
9 |
19 |
92 |
93 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
9 |
19 |
93 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
9 |
19 |
94 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
9 |
20 |
100 |
93 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
9 |
20 |
96 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
9 |
20 |
97 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
9 |
20 |
98 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
9 |
20 |
99 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
21 |
101 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
21 |
102 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
21 |
103 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
21 |
104 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
21 |
105 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
22 |
106 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
22 |
107 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
22 |
108 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
22 |
109 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
22 |
110 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
23 |
111 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
23 |
112 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
23 |
113 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
23 |
114 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
23 |
115 |
93 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
24 |
116 |
93 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
24 |
117 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
24 |
119 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
24 |
120 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
61 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
64 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
65 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
67 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
70 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
23 |
112 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
23 |
113 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
23 |
114 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
23 |
115 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
24 |
116 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
24 |
117 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
24 |
119 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
24 |
120 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
66 |
51 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Endocrine System |
Pituitary Gland |
|
1000 mg/kg |
10 |
23 |
112 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Genital System |
Clitoral Gland |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Clitoral Gland |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Clitoral Gland |
|
Vehicle Control |
10 |
13 |
65 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Genital System |
Ovary |
Left |
125 mg/kg |
1 |
17 |
82 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
14 |
66 |
51 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
13 |
61 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
13 |
64 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
13 |
65 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
14 |
67 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
14 |
70 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
15 |
71 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
15 |
72 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
15 |
73 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
15 |
74 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
15 |
75 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
16 |
76 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
16 |
77 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
16 |
78 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
16 |
79 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
16 |
80 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
17 |
81 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
17 |
82 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
17 |
83 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
17 |
84 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
17 |
85 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
18 |
86 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
18 |
87 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
18 |
88 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
18 |
89 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
18 |
90 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
19 |
91 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
19 |
92 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
19 |
93 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
19 |
94 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
19 |
95 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
20 |
100 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
20 |
96 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
20 |
97 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
20 |
98 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
20 |
99 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
21 |
101 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
21 |
102 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
21 |
103 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
21 |
104 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
21 |
105 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
22 |
106 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
22 |
107 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
22 |
108 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
22 |
109 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
22 |
110 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
23 |
111 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
23 |
112 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
23 |
113 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
23 |
114 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
23 |
115 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
24 |
116 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
24 |
117 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
24 |
119 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
24 |
120 |
93 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
Vehicle Control |
10 |
14 |
66 |
51 |
1 |
Depletion Cellular |
Mild |
Natural Death |
Respiratory System |
Lung |
Bronchiole |
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
13 |
64 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
62.5 mg/kg |
10 |
16 |
76 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
17 |
83 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
18 |
90 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
20 |
96 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
20 |
97 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
14 |
66 |
51 |
1 |
Inflammation |
Mild, Acute |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
62.5 mg/kg |
10 |
15 |
72 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
62.5 mg/kg |
10 |
15 |
72 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
62.5 mg/kg |
10 |
15 |
73 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
62.5 mg/kg |
10 |
15 |
74 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
62.5 mg/kg |
10 |
15 |
75 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
62.5 mg/kg |
10 |
16 |
76 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
62.5 mg/kg |
10 |
16 |
79 |
93 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
17 |
83 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
17 |
84 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
17 |
84 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
17 |
85 |
93 |
1 |
Inflammation |
Marked, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
18 |
87 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
18 |
87 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
18 |
89 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
18 |
89 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
125 mg/kg |
10 |
18 |
90 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
19 |
91 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
19 |
91 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
19 |
92 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
19 |
92 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
19 |
93 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
19 |
94 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
19 |
94 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
19 |
95 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
19 |
95 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
20 |
97 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
20 |
98 |
93 |
1 |
Inflammation |
Marked, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
20 |
99 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
21 |
101 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
21 |
101 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
21 |
102 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
21 |
103 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
21 |
103 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
21 |
104 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
21 |
104 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
21 |
105 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
21 |
105 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
22 |
106 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
22 |
108 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
22 |
110 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
23 |
111 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
23 |
112 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
23 |
113 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
23 |
114 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
23 |
115 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
23 |
115 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
24 |
116 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
24 |
117 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
24 |
119 |
93 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
24 |
120 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
24 |
120 |
93 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
250 mg/kg |
10 |
20 |
97 |
93 |
1 |
Metaplasia, Osseous |
Minimal, Osseous |
Terminal Sacrifice |
Respiratory System |
Nose |
Squam Epithel |
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
Vehicle Control |
10 |
13 |
61 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
Vehicle Control |
10 |
13 |
65 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
Vehicle Control |
10 |
14 |
70 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
1000 mg/kg |
10 |
23 |
112 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
1000 mg/kg |
10 |
23 |
115 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
1000 mg/kg |
10 |
24 |
116 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
Bilateral |
1000 mg/kg |
10 |
24 |
116 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
Bilateral |
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
13 |
61 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
1000 mg/kg |
10 |
23 |
113 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
1000 mg/kg |
10 |
23 |
115 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
66 |
51 |
1 |
Mineralization |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
62 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
63 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
65 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
69 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
70 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
23 |
112 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
23 |
113 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
23 |
114 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
24 |
117 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
24 |
118 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
66 |
51 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
68 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
24 |
116 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |