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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Tetrabromobisphenol A-bis(2,3-dibromopropyl ether)
CASRN: ="21850-44-2"
Study Number: C20321
Exposure Route: GAVAGE
TDMS Number: 2032101
Sex: Male
Strain and Species: F344/N Tac Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Colon, Serosa 1000 mg/kg 10 12 58 93 1 Parasite Metazoan Terminal Sacrifice
Alimentary System Intestine Large Rectum 1000 mg/kg 10 12 56 93 1 Parasite Metazoan Terminal Sacrifice
Alimentary System Intestine Large Rectum 1000 mg/kg 10 12 58 93 1 Parasite Metazoan Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 1 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 2 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 3 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 4 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 5 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 10 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 6 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 7 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 8 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 9 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 3 12 40 1 Inflammation Minimal, Chronic Dosing Accident
Alimentary System Liver 62.5 mg/kg 10 3 14 37 1 Inflammation Minimal, Chronic Natural Death
Alimentary System Liver 62.5 mg/kg 10 3 11 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 3 13 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 3 15 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 16 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 17 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 18 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 19 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 20 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 21 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 22 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 23 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 24 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 25 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 26 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 27 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 28 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 29 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 30 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 31 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 32 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 33 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 34 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 35 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 36 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 37 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 38 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 39 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 40 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 46 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 47 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 48 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 49 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 50 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 41 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 42 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 43 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 44 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 45 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 51 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 52 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 53 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 54 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 55 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 56 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 57 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 58 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 59 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 60 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 1 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 2 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 3 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 4 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 5 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 10 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 6 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 7 93 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 8 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 9 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 3 12 40 1 Vacuolization Cytoplasmic Minimal Dosing Accident
Alimentary System Liver 62.5 mg/kg 10 3 14 37 1 Vacuolization Cytoplasmic Minimal Natural Death
Alimentary System Liver 62.5 mg/kg 10 3 11 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 3 13 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 3 15 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 16 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 17 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 18 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 19 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 62.5 mg/kg 10 4 20 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 21 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 22 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 23 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 24 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 25 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 26 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 27 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 28 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 29 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 6 30 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 31 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 32 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 33 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 34 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 35 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 36 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 37 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 38 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 39 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 40 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 46 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 47 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 48 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 49 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 50 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 41 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 42 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 43 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 44 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 45 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 51 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 52 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 53 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 54 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 11 55 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 56 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 57 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 58 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 59 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 12 60 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Mesentery Fat 1000 mg/kg 1 11 54 93 1 Necrosis Moderate Terminal Sacrifice
Alimentary System Oral Mucosa 500 mg/kg 1 9 41 93 1 Cyst Focal Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 2 6 93 1 Atrophy Minimal Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 2 9 93 1 Atrophy Minimal Terminal Sacrifice
Alimentary System Pancreas Acinus 1000 mg/kg 10 11 51 93 1 Atrophy Minimal Terminal Sacrifice
Alimentary System Pancreas Arteriole Vehicle Control 10 2 7 93 1 Inflammation Minimal Terminal Sacrifice
Alimentary System Pancreas Vehicle Control 10 2 6 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Alimentary System Stomach Glandular, Muscularis 1000 mg/kg 10 12 57 93 1 Mineralization Mild Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 1 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 2 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 3 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 4 93 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 5 93 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 10 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 6 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 7 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 8 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 9 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 62.5 mg/kg 2 3 12 40 1 Cardiomyopathy Minimal Dosing Accident
Cardiovascular System Heart 62.5 mg/kg 2 3 14 37 1 Cardiomyopathy Minimal Natural Death
Cardiovascular System Heart 1000 mg/kg 10 11 51 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 11 52 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 11 53 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 11 54 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 11 55 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 12 56 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 12 57 93 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 12 58 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 12 59 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 12 60 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 6 93 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 5 93 1 Pigmentation Minimal Terminal Sacrifice
Genital System Epididymis Vehicle Control 10 1 1 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Epididymis Vehicle Control 10 1 3 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Epididymis Vehicle Control 10 1 5 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Epididymis Vehicle Control 10 2 10 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Epididymis Vehicle Control 10 2 6 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 1 5 93 1 Inflammation Minimal Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 2 10 93 1 Inflammation Minimal Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 2 9 93 1 Inflammation Minimal Terminal Sacrifice
Genital System Preputial Gland 1000 mg/kg 10 11 51 93 1 Inflammation Mild Terminal Sacrifice
Genital System Preputial Gland 1000 mg/kg 10 11 54 93 1 Inflammation Mild Terminal Sacrifice
Genital System Preputial Gland 1000 mg/kg 10 12 58 93 1 Inflammation Mild Terminal Sacrifice
Genital System Prostate Vehicle Control 10 2 9 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 1 1 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 1 2 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 1 3 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 1 4 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 1 5 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 2 10 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 2 6 93 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 2 7 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 2 8 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 10 2 9 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 62.5 mg/kg 10 3 12 40 1 Infiltration Cellular Moderate, Histiocyte Dosing Accident
Hematopoietic System Lymph Node Mesenteric 62.5 mg/kg 10 3 11 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 62.5 mg/kg 10 3 13 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 62.5 mg/kg 10 3 15 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 62.5 mg/kg 10 4 16 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 62.5 mg/kg 10 4 17 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 62.5 mg/kg 10 4 18 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 62.5 mg/kg 10 4 19 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 62.5 mg/kg 10 4 20 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 5 21 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 5 22 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 5 23 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 5 24 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 5 25 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 6 26 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 6 27 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 6 28 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 6 29 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 125 mg/kg 10 6 30 93 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 7 31 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 7 32 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 7 33 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 7 34 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 7 35 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 8 36 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 8 37 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 8 38 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 8 39 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 250 mg/kg 10 8 40 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 10 46 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 10 47 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 10 48 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 10 49 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 10 50 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 9 41 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 9 42 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 9 43 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 9 44 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 500 mg/kg 10 9 45 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 11 51 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 11 52 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 11 53 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 11 54 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 11 55 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 12 56 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 12 57 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 12 58 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 12 59 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1000 mg/kg 10 12 60 93 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 10 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 62.5 mg/kg 10 4 19 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 9 41 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 11 54 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 1 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 5 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 10 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 6 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 7 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 8 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 9 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 62.5 mg/kg 10 3 12 40 1 Inflammation Mild, Acute Dosing Accident
Respiratory System Lung 62.5 mg/kg 10 3 14 37 1 Inflammation Minimal, Acute Natural Death
Respiratory System Lung 62.5 mg/kg 10 3 13 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 62.5 mg/kg 10 4 16 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 62.5 mg/kg 10 4 18 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 62.5 mg/kg 10 4 20 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 62.5 mg/kg 10 4 20 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 21 93 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 21 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 22 93 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 22 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 23 93 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 23 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 24 93 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 24 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 25 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 5 25 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 6 26 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 6 28 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 6 28 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 6 29 93 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 6 29 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 6 30 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 125 mg/kg 10 6 30 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 7 31 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 7 32 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 7 33 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 7 34 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 7 34 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 8 36 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 8 37 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 8 37 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 8 38 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 8 38 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 8 39 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 8 39 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 8 40 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 250 mg/kg 10 8 40 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 10 46 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 10 46 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 10 47 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 10 48 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 10 49 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 10 50 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 9 41 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 9 41 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 9 42 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 9 43 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 9 44 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 9 44 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 9 45 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 9 45 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 11 51 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 11 53 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 11 54 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 11 55 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 12 56 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 12 57 93 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 12 59 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 12 59 93 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 12 60 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 9 93 1 Metaplasia, Osseous Minimal, Osseous Terminal Sacrifice
Respiratory System Lung 62.5 mg/kg 10 3 13 93 1 Metaplasia, Osseous Minimal, Osseous Terminal Sacrifice
Respiratory System Lung 62.5 mg/kg 10 4 17 93 1 Metaplasia, Osseous Minimal, Osseous Terminal Sacrifice
Respiratory System Nose 1000 mg/kg 10 11 52 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Trachea Vehicle Control 10 2 9 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Respiratory System Trachea 1000 mg/kg 10 11 52 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Respiratory System Trachea 1000 mg/kg 10 12 57 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Special Senses System Harderian Gland Bilateral 1000 mg/kg 10 12 57 93 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 1 2 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 1 3 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Special Senses System Harderian Gland 1000 mg/kg 10 12 59 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 6 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 59 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 60 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 2 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 3 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 4 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 5 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 10 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 7 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 8 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 9 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 62.5 mg/kg 2 3 12 40 1 Mineralization Minimal Dosing Accident
Urinary System Kidney 1000 mg/kg 10 11 51 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 11 52 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 11 53 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 56 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 58 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 60 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 1 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 2 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 3 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 4 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 5 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 10 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 6 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 7 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 8 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 9 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 62.5 mg/kg 2 3 12 40 1 Nephropathy Minimal Dosing Accident
Urinary System Kidney 1000 mg/kg 10 11 51 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 11 52 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 11 53 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 11 54 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 11 55 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 56 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 57 93 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 58 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 59 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 60 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Urinary Bladder Muscularis 1000 mg/kg 10 12 56 93 1 Mineralization Minimal Terminal Sacrifice
Urinary System Urinary Bladder 1000 mg/kg 10 12 56 93 1 Inflammation Minimal, Chronic Terminal Sacrifice