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Short-Term Study Body Weights

Study Information:

Chemical Name: 2,3-Butanedione
CASRN: ="431-03-8"
Study Number: C20725
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 2072501
Sex: FEMALE
Strain and Species: Wistar Han Rats

Animal Number Cage Number Dose Group Days On Study Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 14 Removal Reason
101 3 Vehicle Control 93 146.9 166 172.4 182 189.4 204.5 209.8 220.3 224.3 218.2 231.7 235.9 238.5 Terminal Sacrifice
102 3 Vehicle Control 93 142.8 164.4 176.9 184.9 198.7 206 210.7 211.6 223.1 228.4 232.4 231.3 232.4 Terminal Sacrifice
103 3 Vehicle Control 93 158.6 177.1 194.4 203.5 212.2 219.5 223 227.9 227.7 235.8 238 238.9 241.8 Terminal Sacrifice
104 3 Vehicle Control 93 152.4 173 189.6 196.4 214.3 223 228 229.1 239.9 246.9 249.3 248.7 249.2 Terminal Sacrifice
105 3 Vehicle Control 93 160.1 186.2 193.6 207.2 223.9 232 230.2 244.2 250.6 251.7 253 260.2 266 Terminal Sacrifice
106 4 Vehicle Control 93 148.7 165.8 172.2 192.6 201.3 209.6 211.7 225 230.4 231.2 230.9 242.1 249.2 Terminal Sacrifice
107 4 Vehicle Control 93 146.8 158.4 171.3 180.4 182.8 185.6 192.3 199.5 203.4 200.7 208.5 208.5 212.6 Terminal Sacrifice
108 4 Vehicle Control 93 136.9 153.5 164.9 172.1 181.8 189.8 196.9 196.8 204.5 206.7 209.5 208.3 212.8 Terminal Sacrifice
109 4 Vehicle Control 93 148.2 165.3 176.5 195.4 204.2 214 215.3 225.5 234.7 236.3 236.7 246.7 249.4 Terminal Sacrifice
110 4 Vehicle Control 93 141 156.2 165.1 172.1 185.2 190.7 195 194.5 205.9 210.7 207.8 208.2 211.9 Terminal Sacrifice
301 7 6.25ppm 93 146.5 173 189.5 198 199.7 218.2 225.6 230.6 231.8 241.3 243.4 242.8 250.3 Terminal Sacrifice
302 7 6.25ppm 93 144.1 155.1 167.2 172.6 184 194.4 196.6 201.2 208.8 213 215.4 213.9 218.3 Terminal Sacrifice
303 7 6.25ppm 93 144.8 156.6 165.5 169.7 185.1 188.8 189.8 202.6 207.1 210.4 208.4 219.9 226.6 Terminal Sacrifice
304 7 6.25ppm 93 138.1 154.3 164.1 163.9 182.4 188 199.5 193.8 210.7 214.3 213.8 209.4 213.4 Terminal Sacrifice
305 7 6.25ppm 93 136.5 154.9 172 177.1 192.2 202.6 208.2 205.7 220.3 226.9 230.9 228.8 237.5 Terminal Sacrifice
306 8 6.25ppm 93 150.7 169.8 185.4 191.3 207.9 218 224.2 225.9 235.9 240.5 241.2 237.2 240.9 Terminal Sacrifice
307 8 6.25ppm 93 139.6 154.2 158.7 175.3 190 190.7 192.8 203.9 215.3 217.2 212.6 223.2 234.3 Terminal Sacrifice
308 8 6.25ppm 93 155 174.2 192.5 197 219.8 233.6 243.3 238 256.3 259.9 257.9 255.5 257.1 Terminal Sacrifice
309 8 6.25ppm 93 140 146.4 163.5 173.3 175.6 181.6 195.4 200.8 204.9 206.6 214.1 219 224.9 Terminal Sacrifice
310 8 6.25ppm 93 146.3 159.6 182.3 195.3 202.9 212 221.6 230 227.3 232.1 241.3 242.4 246 Terminal Sacrifice
501 11 12.5ppm 93 136.6 151.1 163.8 168.5 183 194.9 201.5 195.2 206.5 210.2 211.6 209.8 213.8 Terminal Sacrifice
502 11 12.5ppm 93 127.5 144.7 155.1 164.8 164.4 177.5 186.5 191.6 190.9 200.3 202.4 201.5 206.5 Terminal Sacrifice
503 11 12.5ppm 93 147.5 168.7 178.3 190.4 192.5 207.8 218.6 217.8 216.8 227.4 233.3 232.5 235.2 Terminal Sacrifice
504 11 12.5ppm 93 137 151.2 166.9 178.3 188.9 194.2 199.1 206.5 213.1 214.9 214.3 216.5 220 Terminal Sacrifice
505 11 12.5ppm 93 134.9 152.5 165 171 185.1 195.1 201.4 199.7 211.4 217.8 218.9 216.4 221 Terminal Sacrifice
506 12 12.5ppm 93 136.2 154.2 173.9 179.5 197.5 206.8 218.5 220.9 224.7 228.5 233.8 237.6 242.3 Terminal Sacrifice
507 12 12.5ppm 93 159 171.9 188 193.3 207.4 213.5 218.4 218.5 227.1 230.9 237 230.6 231.9 Terminal Sacrifice
508 12 12.5ppm 93 156 171.8 188.8 196 213.2 223.5 227.1 233 244.5 248 248.2 245.3 253 Terminal Sacrifice
509 12 12.5ppm 93 148.2 152.4 158.7 164.6 183.2 194.4 198.1 204.6 221.2 228.4 225.7 225.1 230.8 Terminal Sacrifice
510 12 12.5ppm 93 139.8 158.7 166.5 177.1 180.2 195.5 200 207.1 212.9 217.9 221.3 224.6 226.9 Terminal Sacrifice
701 15 25ppm 93 151.1 171.4 182.2 183.7 198.2 212.7 216.5 213.7 222.9 227.3 230.7 225.6 227.8 Terminal Sacrifice
702 15 25ppm 93 143.2 156.8 161 172.3 178 183.5 186.1 196.7 201.2 204.3 206.1 214.7 214.1 Terminal Sacrifice
703 15 25ppm 93 141.4 161.1 168.1 173.6 183.2 194.2 197 202.1 213.8 217.6 221.9 221.8 228.4 Terminal Sacrifice
704 15 25ppm 93 149 159.6 171 176.5 187.1 192.5 195.6 199.4 210.4 208.9 215.4 213.3 214 Terminal Sacrifice
705 15 25ppm 93 138.2 150.4 165.4 175.4 180.2 184.4 196.3 201.3 201.9 203.2 215.2 219.4 222.8 Terminal Sacrifice
706 16 25ppm 93 130.8 141.6 158 170.8 170.6 174.4 188.6 194.2 198 197 205.2 204.1 208.5 Terminal Sacrifice
707 16 25ppm 93 157.4 176.8 188.6 187.4 208.6 216.9 224.5 222.4 236.3 243.6 246.5 241.6 242.2 Terminal Sacrifice
708 16 25ppm 93 136.9 159.4 167.1 187.1 200.3 207.2 205.4 219.1 234.5 238.2 236.5 244.4 247.2 Terminal Sacrifice
709 16 25ppm 93 135.4 150.3 167.6 179.6 183.5 189.2 199.8 205.7 209.3 208.5 215.6 219.6 224.2 Terminal Sacrifice
710 16 25ppm 93 149.2 164.9 181.6 187.8 191.4 204.3 210.3 212.9 212.9 218.8 225 226.6 229.1 Terminal Sacrifice
901 19 50ppm 93 141.4 160 169.7 185.2 194.2 185 200.9 207.6 212.3 215.2 217.7 221.7 224.7 Terminal Sacrifice
902 19 50ppm 93 146.5 175.1 194.1 208 211.7 228.1 234.8 233.8 243.3 259 265 264.6 269.2 Terminal Sacrifice
903 19 50ppm 93 144.9 167.6 184.8 194.9 208.1 217.2 219.5 229.2 236.5 235.7 237.4 241.8 245.5 Terminal Sacrifice
904 19 50ppm 93 140.4 156.8 175.8 183.7 188.2 194.8 200.9 202.9 209.3 206.6 211 215 219 Terminal Sacrifice
905 19 50ppm 93 136.1 157.6 169.4 177.3 189.3 201.2 201.2 204.9 214.7 223.7 223.1 223.7 223.6 Terminal Sacrifice
906 20 50ppm 93 146.5 160.5 175.7 187.5 187.9 196.6 206.6 212.6 214.3 217.7 224.2 228.6 229.6 Terminal Sacrifice
907 20 50ppm 93 148.5 166 175 183 188.6 202.4 212 214.3 223.5 225.7 233.3 230.5 231.1 Terminal Sacrifice
908 20 50ppm 93 140.3 162.7 175.5 179.6 191.3 202.5 206.9 205.5 218.4 224.8 225.4 223.8 231.7 Terminal Sacrifice
909 20 50ppm 93 134.1 154.5 165.4 172.8 170.7 176.6 184.5 191.2 191.1 197.4 201.3 199.1 202.6 Terminal Sacrifice
910 20 50ppm 93 139.7 158.1 176.6 187.7 189 207.4 214.3 219.7 221.5 230.7 236.6 237.1 242.3 Terminal Sacrifice
1101 23 100ppm 93 136.8 157.9 168.1 183 186.5 191.1 197.9 203 206.6 188.5 188.8 197.3 193.6 Terminal Sacrifice
1102 23 100ppm 93 148 165.5 177.3 189 196.5 205.5 207.3 215.5 217.2 220.5 222.4 218.8 226.4 Terminal Sacrifice
1103 23 100ppm 93 147.4 169.3 174.9 190.1 195.2 205.4 210.1 215.8 212.7 216 220.7 227.4 225.3 Terminal Sacrifice
1104 23 100ppm 93 153.4 170.4 182.5 191 198 207.1 210.6 216.6 217.2 218.6 224.4 224.9 189.2 Terminal Sacrifice
1105 23 100ppm 93 142 157.4 171.8 178 191.6 196.8 202.7 200.6 212.9 221.2 219 218.7 224.9 Terminal Sacrifice
1106 24 100ppm 93 126.6 144.8 150.8 166 171.1 175.6 178 189.2 192.7 195.2 194.5 173.4 135.6 Terminal Sacrifice
1107 24 100ppm 93 146.4 164.6 180.1 192.7 201.6 207.7 213.8 220.9 223.9 221.3 222.4 228.8 226.2 Terminal Sacrifice
1108 24 100ppm 93 138.8 153.8 169.6 180.6 187.7 192.5 197.9 199.9 198.2 197.3 204.3 209.8 212.5 Terminal Sacrifice
1109 24 100ppm 93 137.2 156.6 171 179.6 187.6 196.2 203.2 208.1 206.4 210.5 217.2 220.2 222.8 Terminal Sacrifice
1110 24 100ppm 93 131.4 157.4 169.9 184.9 186.8 198.3 201.9 208.1 214.4 218.4 222.5 222.4 223.9 Terminal Sacrifice
* All body weights in grams