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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 2,3-Butanedione
CASRN: ="431-03-8"
Study Number: C20725
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 2072501
Sex: FEMALE
Strain and Species: Wistar Han Rats

FEMALE Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Vehicle Control 10 4 108 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 10 3 101 93 1 Cyst Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 100 ppm 10 24 1108 93 1 Cyst Terminal Sacrifice
Genital System Clitoral Gland Vehicle Control 10 3 101 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland Vehicle Control 10 3 102 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland Vehicle Control 10 3 105 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 50 ppm 1 20 907 93 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 100 ppm 10 23 1103 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Clitoral Gland 100 ppm 10 24 1106 93 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Genital System Ovary 100 ppm 10 23 1105 93 1 Cyst Mild Terminal Sacrifice
Hematopoietic System Lymph Node Deep Cervical 100 ppm 10 23 1101 93 1 Hyperplasia Minimal, Lymphoid Terminal Sacrifice
Hematopoietic System Spleen 100 ppm 10 23 1104 93 1 Atrophy Moderate, Lymphoid Terminal Sacrifice
Hematopoietic System Spleen 100 ppm 10 24 1106 93 1 Atrophy Moderate, Lymphoid Terminal Sacrifice
Hematopoietic System Thymus 100 ppm 10 23 1104 93 1 Atrophy Mild, Lymphoid Terminal Sacrifice
Hematopoietic System Thymus 25 ppm 1 15 703 93 1 Hemorrhage Mild Terminal Sacrifice
Respiratory System Larynx Epithelium 100 ppm 10 23 1101 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Larynx Epithelium 100 ppm 10 23 1103 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Larynx Epithelium 100 ppm 10 23 1105 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Larynx Epithelium 100 ppm 10 24 1107 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Larynx Epithelium 100 ppm 10 24 1108 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Larynx Epithelium 100 ppm 10 24 1109 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 23 1105 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 24 1107 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 19 901 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 19 902 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 19 905 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 20 906 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 20 907 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 20 908 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 20 909 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 20 910 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 23 1101 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 23 1102 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 23 1103 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 23 1104 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 23 1105 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 24 1106 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 24 1107 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 24 1108 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 24 1109 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 24 1110 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 24 1109 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 23 1101 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 23 1102 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 23 1104 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 23 1105 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 24 1106 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 24 1107 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 24 1108 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 24 1109 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 24 1110 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx 100 ppm 10 23 1103 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Larynx 100 ppm 10 23 1105 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Larynx 100 ppm 10 24 1106 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Larynx 100 ppm 10 24 1109 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Larynx 100 ppm 10 24 1110 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Alveolar Epith 6.25 ppm 10 8 310 93 1 Inflammation Minimal, Focal, Acute Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 23 1102 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 23 1103 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 23 1104 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 23 1105 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 24 1106 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 24 1107 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 24 1108 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 24 1109 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 23 1101 93 1 Hyperplasia Mild, Atypical Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 23 1102 93 1 Hyperplasia Mild, Atypical Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 23 1103 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 23 1104 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 23 1105 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 24 1106 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 24 1107 93 1 Hyperplasia Mild, Atypical Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 24 1108 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 24 1109 93 1 Hyperplasia Mild, Atypical Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 24 1107 93 1 Metaplasia Mild, Squamous Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 24 1109 93 1 Metaplasia Mild, Squamous Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 23 1101 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 24 1107 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 23 1101 93 1 Regeneration Moderate Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 23 1102 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 24 1107 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 24 1109 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Lung 100 ppm 10 23 1104 93 1 Foreign Body Terminal Sacrifice
Respiratory System Lung 100 ppm 10 24 1106 93 1 Foreign Body Terminal Sacrifice
Respiratory System Lung 100 ppm 10 23 1105 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 100 ppm 10 24 1108 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 100 ppm 10 24 1109 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 3 101 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 3 105 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 4 107 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 4 110 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 6.25 ppm 10 7 304 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 6.25 ppm 10 8 308 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 6.25 ppm 10 8 309 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 25 ppm 10 16 709 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 50 ppm 10 19 901 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 23 1101 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 23 1103 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 23 1104 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 23 1105 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 24 1106 93 1 Inflammation Moderate, Acute Terminal Sacrifice
Respiratory System Lung 100 ppm 10 24 1107 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 24 1108 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 24 1109 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 6.25 ppm 10 8 306 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 25 ppm 10 15 701 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 25 ppm 10 15 702 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 19 901 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 19 903 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 19 904 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 19 905 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 20 906 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 20 907 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 20 908 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 20 909 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 23 1101 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 23 1102 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 23 1104 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 23 1105 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 24 1107 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 24 1108 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1101 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1104 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1106 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1107 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 ppm 10 15 703 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 ppm 10 16 706 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 ppm 10 16 709 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 ppm 10 16 710 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 19 901 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 19 902 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 19 904 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 19 905 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 906 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 907 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 908 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 909 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 910 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1101 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1108 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1109 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1110 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 19 901 93 1 Metaplasia, Respiratory Moderate, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 19 902 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 19 903 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 19 904 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 19 905 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 906 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 907 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 908 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 909 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 20 910 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1101 93 1 Metaplasia, Respiratory Moderate, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1102 93 1 Metaplasia, Respiratory Moderate, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1103 93 1 Metaplasia, Respiratory Moderate, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1104 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1105 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1106 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1107 93 1 Metaplasia, Respiratory Moderate, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1108 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1109 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 24 1110 93 1 Metaplasia, Respiratory Moderate, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1101 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1102 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1103 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 23 1105 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 901 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 902 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 903 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 904 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 905 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 906 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 907 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 908 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 909 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 910 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1101 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1102 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1103 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1104 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1105 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1106 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1107 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1108 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1109 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1110 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 15 702 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 15 703 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 15 704 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 16 708 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 16 709 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 901 93 1 Metaplasia Mild, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 902 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 903 93 1 Metaplasia Mild, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 904 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 905 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 906 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 907 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 908 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 909 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 910 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1101 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1102 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1103 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1104 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1105 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1106 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1107 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1108 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1109 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1110 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 902 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 909 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 910 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1101 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1102 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1103 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1104 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1105 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1106 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1107 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1108 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1109 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1110 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 19 902 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 906 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 20 910 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1101 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1102 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1103 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1104 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 23 1105 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1106 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1108 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1109 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 24 1110 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Septum 100 ppm 10 24 1107 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Septum 100 ppm 10 24 1109 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 50 ppm 10 19 901 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 50 ppm 10 19 902 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 50 ppm 10 20 906 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 50 ppm 10 20 907 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 23 1101 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 23 1102 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 23 1103 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 23 1104 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 23 1105 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 24 1106 93 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 24 1107 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 24 1108 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 24 1109 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 24 1110 93 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose 50 ppm 10 19 901 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 19 902 93 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 19 903 93 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 19 904 93 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 19 905 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 20 906 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 20 907 93 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 20 908 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 20 909 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 20 910 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 23 1101 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 23 1102 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 23 1103 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 23 1104 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 23 1105 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 24 1106 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 24 1107 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 24 1108 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 24 1109 93 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 24 1110 93 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1102 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1103 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1104 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1105 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1106 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1107 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1108 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1109 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1110 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 50 ppm 10 19 901 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1101 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1102 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1103 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1104 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1105 93 1 Necrosis Marked Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1106 93 1 Necrosis Marked Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1107 93 1 Necrosis Marked Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1108 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1109 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1110 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 50 ppm 10 19 901 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 50 ppm 10 20 909 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1101 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1102 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1103 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1104 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 23 1105 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1106 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1107 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1108 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1109 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 24 1110 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea 100 ppm 10 24 1110 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Special Senses System Eye Cornea 50 ppm 10 20 906 93 1 Inflammation Mild, Acute Terminal Sacrifice
Special Senses System Eye Cornea 100 ppm 10 23 1101 93 1 Inflammation Mild, Acute Terminal Sacrifice
Special Senses System Eye Cornea 100 ppm 10 23 1105 93 1 Inflammation Minimal, Acute Terminal Sacrifice
Special Senses System Eye Cornea 100 ppm 10 24 1106 93 1 Inflammation Minimal, Acute Terminal Sacrifice
Special Senses System Eye Cornea 100 ppm 10 23 1101 93 1 Neovascularization Minimal Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 4 108 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 3 105 93 1 Nephropathy Minimal Terminal Sacrifice