If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Short-Term Study Body Weights

Study Information:

Chemical Name: 2,3-Butanedione
CASRN: ="431-03-8"
Study Number: C20725
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 2072501
Sex: MALE
Strain and Species: Wistar Han Rats

Animal Number Cage Number Dose Group Days On Study Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Removal Reason
1 1 Vehicle Control 93 132.5 191.1 235.6 282.3 310.4 339.4 363.1 378.5 392.5 404.3 418.1 423.8 417.7 435 Terminal Sacrifice
2 1 Vehicle Control 93 132.4 179 213.6 242.2 260.5 280.3 297.4 308 320 327.1 335.1 339 344.5 349.8 Terminal Sacrifice
3 1 Vehicle Control 93 148.2 199.8 244.8 284.1 315.3 339.4 359.2 373 388.4 393.9 411.5 417.3 425.6 426.6 Terminal Sacrifice
4 1 Vehicle Control 93 150.6 203.2 245.4 276.3 301.3 324.4 348.8 357.3 370.6 381.2 390 395.8 402.8 407 Terminal Sacrifice
5 1 Vehicle Control 93 137.3 189.4 234.3 272.2 305.5 318.6 347.6 369 382.1 393.5 406.9 414.4 426.6 436.2 Terminal Sacrifice
6 2 Vehicle Control 93 144.4 190 227.9 262.1 285.2 311.5 323.7 337.2 347.2 361.1 363.8 371.1 380.1 384.5 Terminal Sacrifice
7 2 Vehicle Control 93 135.9 185.2 227.9 255.4 284.9 313.2 335.5 345.8 360 375.4 385.7 394.1 397.7 406.9 Terminal Sacrifice
8 2 Vehicle Control 93 152.6 203.2 239.6 272.3 297.7 320.8 343.1 359.8 370.7 384.4 394.7 404.5 414.9 424.4 Terminal Sacrifice
9 2 Vehicle Control 93 154.7 204 249.8 280.3 308.8 330.3 347.2 358.7 370 386.1 395.6 406.1 412.8 417.7 Terminal Sacrifice
10 2 Vehicle Control 93 143.5 193.5 238.7 271.3 299.5 320.8 337.4 354.6 368.6 380 389.4 398.2 404.3 410.9 Terminal Sacrifice
201 5 6.25ppm 93 133.8 183.6 220.5 253.4 271.2 294.8 310.5 327.6 336.6 347 362 366.6 365.4 377.9 Terminal Sacrifice
202 5 6.25ppm 93 157 216 267.6 316.2 349.8 377.9 400.3 418.3 431.3 442.9 459.6 467.9 480.9 491.3 Terminal Sacrifice
203 5 6.25ppm 93 147.4 200 236 272.3 296.3 316.2 333.5 346.9 353.3 364.5 371.2 382.1 384 390.2 Terminal Sacrifice
204 5 6.25ppm 93 135.5 177.7 210.6 240 261.9 283.3 294.1 311.2 316.5 328.4 333.8 337.2 344.8 346.9 Terminal Sacrifice
205 5 6.25ppm 93 144.6 197.9 238.9 274.8 308.3 332 352.4 361.9 383.3 399 408.2 411.6 416.1 410.5 Terminal Sacrifice
206 6 6.25ppm 93 129.9 179.9 216.2 252.8 281.8 302.1 320.6 336.5 352.2 364.6 369.7 382.3 390.1 401.1 Terminal Sacrifice
207 6 6.25ppm 93 143.1 197.3 237.8 265.8 292.9 314.4 334.5 351.8 361.3 376.9 379.2 392.4 402 407 Terminal Sacrifice
208 6 6.25ppm 93 156.7 207.7 251 284.9 314.6 342.7 365.5 377.9 393.4 409.1 418.9 428 443.1 445.9 Terminal Sacrifice
209 6 6.25ppm 93 139.7 188.1 225.3 251.4 275 294.8 308.9 320.8 331.9 345.4 350 357.3 363.6 370.7 Terminal Sacrifice
210 6 6.25ppm 93 147.8 196.3 232.8 261.5 282.5 298.1 313.6 328.7 337.6 344.6 350.2 358.3 362 369.7 Terminal Sacrifice
401 9 12.5ppm 93 148.5 199.6 237.6 259.5 287.2 306.7 318.6 335.7 339.4 349 352.3 362.1 364.5 371.3 Terminal Sacrifice
402 9 12.5ppm 93 133.7 184.5 225.6 269.4 301.1 324.1 344.2 358.7 368.9 380.8 390.9 402 407.5 410.3 Terminal Sacrifice
403 9 12.5ppm 93 129.7 170.5 212.4 245 270.4 294.1 312.4 331.5 346.9 353.8 363.2 375.4 384.2 391.7 Terminal Sacrifice
404 9 12.5ppm 93 142.2 193.5 233 259.4 287.1 307.1 321.5 330.8 344.2 352.7 364.7 368.8 379.4 382.7 Terminal Sacrifice
405 9 12.5ppm 93 140 180.2 212.1 236.7 260 277.9 290 300.5 309.9 316.2 318.4 322 327.2 334 Terminal Sacrifice
406 10 12.5ppm 93 143.4 185.7 216 249.1 273.3 292.8 312.6 329.7 340.4 352.3 363.2 373.2 381.6 388.4 Terminal Sacrifice
407 10 12.5ppm 93 134.5 179 214 243.6 272.2 293.2 312.7 325 334 340 346.9 351.5 357.8 366.9 Terminal Sacrifice
408 10 12.5ppm 93 153.4 202.9 244.2 275.4 299.2 328.4 348 355.8 368.5 374.8 385.7 393.5 400.2 407.3 Terminal Sacrifice
409 10 12.5ppm 93 151.5 202.8 240.3 277.7 302.1 329.8 343.2 360.9 377.2 386.5 398.8 409.9 413 424.2 Terminal Sacrifice
410 10 12.5ppm 93 144.1 190.6 228.5 258.8 284 304.3 321.4 336.6 347.1 360.5 368.3 374.4 381.7 387.4 Terminal Sacrifice
601 13 25ppm 93 157.2 219.1 265.2 309.5 341.3 362.8 389.9 409.4 424.3 434.1 444.9 450.9 457.2 467.5 Terminal Sacrifice
602 13 25ppm 93 138.6 202.3 258.8 298.2 326 350.8 372.7 397.3 415.3 432.2 444.4 459.5 470.8 485 Terminal Sacrifice
603 13 25ppm 93 141.8 195 245.8 281.1 314.4 336.7 358.4 376.7 388.9 408.9 418.7 430.3 438.2 449.6 Terminal Sacrifice
604 13 25ppm 93 149.8 196 230.4 257.6 279 301.4 316.1 330.1 343.1 351.6 358.7 366.3 369.5 375.3 Terminal Sacrifice
605 13 25ppm 93 134.2 181.5 218.7 250.9 273.2 290.3 303.7 324.7 335.2 346.4 356.1 365 373.1 385.1 Terminal Sacrifice
606 14 25ppm 93 132.6 170.1 202.8 225.9 248 266.5 284.1 297.8 309.7 319.5 328.4 333.7 340.9 336.9 Terminal Sacrifice
607 14 25ppm 93 153.7 199.4 244.7 274.8 302.3 321.1 343.9 360.1 369.1 380.4 389 396 401.7 409.6 Terminal Sacrifice
608 14 25ppm 93 146.5 196.2 240.9 275.2 307.5 326.2 352.8 369.1 385.9 395.3 404.7 416.1 425.3 429.3 Terminal Sacrifice
609 14 25ppm 93 142.6 189.7 227.7 254.5 276.2 293.8 309.8 323.5 331.1 343.5 349.7 352.3 357.4 361.6 Terminal Sacrifice
610 14 25ppm 93 137.3 179.7 217.6 245.2 270.1 288.9 306.8 320.2 331.5 342.6 349.4 359 365 373.2 Terminal Sacrifice
801 17 50ppm 93 134 180.2 215.3 248.7 276.4 287.7 310.2 324.2 334.4 345.2 356.9 364 366.1 373.9 Terminal Sacrifice
802 17 50ppm 93 140.9 179.7 216.2 237.3 256.9 274.6 295.3 303.6 312.3 316.6 323.6 332.1 335.1 340.8 Terminal Sacrifice
803 17 50ppm 93 150.3 199.2 236.5 268.1 292.5 315.2 328.6 341.2 351.6 360.1 371 378.5 381 385.3 Terminal Sacrifice
804 17 50ppm 93 156.3 202.7 238.3 264.2 288.4 313.2 330.4 351.1 361.6 373.3 378.9 394.5 401.7 412.8 Terminal Sacrifice
805 17 50ppm 93 157.1 209.4 251.1 268.9 301.3 324 342.6 362.8 375.5 385.7 396.5 409.5 412.6 424.5 Terminal Sacrifice
806 18 50ppm 93 134.1 179.8 213.1 243.2 269.3 290.5 310.1 327.8 340.3 348.3 356.5 368 371.8 379.7 Terminal Sacrifice
807 18 50ppm 93 143.1 187.1 222.1 257.7 280.2 304.3 326.6 343.2 360.8 370.2 378.3 389.8 397 405.9 Terminal Sacrifice
808 18 50ppm 93 140.5 184.4 226.2 258.1 283.2 304.5 326.3 344 357.7 362.9 375.3 383.7 386.3 394.8 Terminal Sacrifice
809 18 50ppm 93 151.7 195.4 232.2 261.6 279.4 298.5 315.8 330.9 335.6 346.7 352 361.1 367.4 371.4 Terminal Sacrifice
810 18 50ppm 93 129.2 171.7 199.7 235.8 259.3 282.3 301 319.2 329.8 340.3 350.6 359.5 364.5 378.3 Terminal Sacrifice
1001 21 100ppm 93 142 175.7 205.8 227 234.1 251.5 270.5 282.4 288.4 293.2 293.9 307.5 310.3 309.6 Terminal Sacrifice
1002 21 100ppm 93 155.2 192.8 242.1 272.7 298.7 328.8 350.2 364.4 372.3 391 393.6 399.8 396.7 401.8 Terminal Sacrifice
1003 21 100ppm 93 131.7 164.3 188.7 223.5 238.1 246.8 259.6 271.8 288.2 296.8 289.6 260.1 290.6 300.7 Terminal Sacrifice
1004 21 100ppm 92 131.7 175.6 207.4 235 253.4 265.9 276.6 293.7 296.9 282.1 274.6 261.8 182.7 Natural Death
1005 21 100ppm 93 131.6 151.6 186.7 220.5 240.6 257.9 273.4 289.4 290.6 304.6 314.6 320.1 326.5 329.1 Terminal Sacrifice
1006 22 100ppm 93 144.7 165.9 184.5 205.6 229.8 241.4 247.8 253.3 262.2 281.2 280.4 295.2 302.8 303.3 Terminal Sacrifice
1007 22 100ppm 93 156.7 193 233.4 265.6 281.4 297.3 323.1 336.1 344.7 352.4 350.3 356.2 360.5 338.4 Terminal Sacrifice
1008 22 100ppm 91 132.3 167 199 233.7 257.9 268.1 290.9 305.4 316.3 325.3 305.4 311.4 276.5 Natural Death
1009 22 100ppm 93 152.6 185.1 213.7 237.8 258.6 283.6 305.1 323.2 335 332 336.1 341.8 344.4 345 Terminal Sacrifice
1010 22 100ppm 93 135.9 167.8 201.2 227.1 252.7 266 287.5 301.3 316 324.4 327.6 334.8 331 337 Terminal Sacrifice
* All body weights in grams