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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 2,3-Butanedione
CASRN: ="431-03-8"
Study Number: C20725
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 2072501
Sex: MALE
Strain and Species: Wistar Han Rats

MALE Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Pancreas Vehicle Control 10 1 2 93 1 Atrophy Minimal Terminal Sacrifice
Alimentary System Pancreas Vehicle Control 10 1 3 93 1 Atrophy Mild Terminal Sacrifice
Alimentary System Pancreas Vehicle Control 10 2 8 93 1 Atrophy Mild Terminal Sacrifice
Alimentary System Pancreas 100 ppm 10 22 1010 93 1 Basophilic Focus Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 2 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 100 ppm 10 22 1006 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 1 4 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 1 5 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 2 10 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Preputial Gland 100 ppm 10 21 1001 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Preputial Gland 100 ppm 10 21 1003 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Preputial Gland 100 ppm 10 22 1006 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Prostate Vehicle Control 10 1 2 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Prostate Vehicle Control 10 1 4 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Prostate 100 ppm 10 21 1004 92 1 Inflammation Minimal, Chronic Active Natural Death
Genital System Prostate 100 ppm 10 22 1008 91 1 Inflammation Moderate, Chronic Active Natural Death
Genital System Prostate 100 ppm 10 21 1002 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Prostate 100 ppm 10 21 1003 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Prostate 100 ppm 10 22 1006 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Genital System Prostate 100 ppm 10 22 1009 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 100 ppm 10 21 1004 92 1 Atrophy Marked, Lymphoid Natural Death
Hematopoietic System Lymph Node Mandibular 50 ppm 1 17 802 93 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 100 ppm 10 21 1004 92 1 Atrophy Moderate, Lymphoid Natural Death
Hematopoietic System Spleen 100 ppm 10 21 1004 92 1 Atrophy Moderate, Lymphoid Natural Death
Hematopoietic System Thymus 100 ppm 10 21 1004 92 1 Atrophy Marked, Lymphoid Natural Death
Respiratory System Larynx Epithelium 100 ppm 10 21 1001 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Larynx Epithelium 100 ppm 10 21 1002 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 17 801 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 17 804 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 18 807 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 22 1006 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 17 801 93 1 Metaplasia Mild, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 17 804 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 17 805 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 18 806 93 1 Metaplasia Mild, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 18 807 93 1 Metaplasia Mild, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 18 808 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 18 809 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 50 ppm 10 18 810 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 21 1004 92 1 Metaplasia Marked, Squamous Natural Death
Respiratory System Larynx Respirat Epith 100 ppm 10 22 1008 91 1 Metaplasia Moderate, Squamous Natural Death
Respiratory System Larynx Respirat Epith 100 ppm 10 21 1001 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 21 1002 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 21 1003 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 21 1005 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 22 1006 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 22 1007 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 22 1009 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Larynx Respirat Epith 100 ppm 10 22 1010 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 21 1004 92 1 Hyperplasia Mild Natural Death
Respiratory System Larynx Squam Epithel 100 ppm 10 22 1008 91 1 Hyperplasia Mild Natural Death
Respiratory System Larynx Squam Epithel 100 ppm 10 21 1001 93 1 Hyperplasia Mild, Atypical Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 21 1002 93 1 Hyperplasia Mild, Atypical Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 21 1005 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 22 1006 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Squam Epithel 100 ppm 10 22 1007 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx 100 ppm 10 21 1001 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Larynx 100 ppm 10 22 1006 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 21 1003 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 22 1006 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 22 1007 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 22 1009 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 100 ppm 10 22 1010 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchus 100 ppm 10 21 1001 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 21 1001 93 1 Hyperplasia Mild, Atypical Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 21 1002 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 21 1003 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 21 1005 93 1 Hyperplasia Mild, Atypical Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 22 1006 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 22 1007 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 22 1009 93 1 Hyperplasia Mild, Atypical Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 22 1008 91 1 Necrosis Marked Natural Death
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 21 1005 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 22 1007 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 22 1009 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 22 1008 91 1 Regeneration Moderate Natural Death
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 21 1002 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 21 1005 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 22 1007 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Lung Bronchus, Epithelium 100 ppm 10 22 1009 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Lung 100 ppm 10 22 1008 91 1 Congestion Mild Natural Death
Respiratory System Lung 100 ppm 10 21 1002 93 1 Congestion Mild Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 10 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 12.5 ppm 10 9 403 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 100 ppm 10 22 1008 91 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung 100 ppm 10 21 1001 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 100 ppm 10 21 1002 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 100 ppm 10 21 1005 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 100 ppm 10 22 1006 93 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung 100 ppm 10 22 1007 93 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung 100 ppm 10 22 1009 93 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 3 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 8 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 12.5 ppm 10 10 409 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 12.5 ppm 10 10 410 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 12.5 ppm 10 9 403 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 25 ppm 10 13 605 93 1 Inflammation Minimal, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 21 1004 92 1 Inflammation Marked, Acute Natural Death
Respiratory System Lung 100 ppm 10 22 1008 91 1 Inflammation Minimal, Eosinophil Natural Death
Respiratory System Lung 100 ppm 10 21 1003 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 22 1006 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 22 1007 93 1 Inflammation Moderate, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 22 1009 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung 100 ppm 10 22 1010 93 1 Inflammation Mild, Eosinophil Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 4 93 1 Metaplasia, Osseous Minimal, Osseous Terminal Sacrifice
Respiratory System Lung 100 ppm 10 21 1001 93 1 Metaplasia, Osseous Minimal, Osseous Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 25 ppm 10 13 601 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 25 ppm 10 13 602 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 25 ppm 10 14 609 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 17 801 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 17 802 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 17 803 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 17 804 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 17 805 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 18 807 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 18 808 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 18 809 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 50 ppm 10 18 810 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 21 1002 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 21 1003 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 21 1005 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 22 1007 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 22 1009 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Lymphoid Tiss 100 ppm 10 22 1010 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 22 1010 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 ppm 10 13 601 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 ppm 10 13 602 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 ppm 10 14 608 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 17 801 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 17 802 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 17 803 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 17 804 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 806 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 807 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 808 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 809 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 810 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 ppm 10 13 602 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 ppm 10 14 608 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 17 803 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 17 805 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 806 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 807 93 1 Metaplasia, Respiratory Moderate, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 808 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 809 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 ppm 10 18 810 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1004 92 1 Metaplasia, Respiratory Minimal, Respiratory Natural Death
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1001 93 1 Metaplasia, Respiratory Minimal, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1002 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1003 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1005 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 22 1006 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 22 1007 93 1 Metaplasia, Respiratory Moderate, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 22 1009 93 1 Metaplasia, Respiratory Mild, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 22 1010 93 1 Metaplasia, Respiratory Moderate, Respiratory Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1004 92 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 100 ppm 10 22 1008 91 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1001 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1002 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1003 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 21 1005 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 22 1006 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 22 1007 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 ppm 10 22 1010 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 13 601 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 13 602 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 801 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 802 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 803 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 804 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 805 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 806 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 807 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 808 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 809 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 810 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1004 92 1 Hyperplasia Minimal Natural Death
Respiratory System Nose Respirat Epith 100 ppm 10 21 1001 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1002 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1003 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1005 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1006 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1007 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1009 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1010 93 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 13 601 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 13 602 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 13 603 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 13 605 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 14 606 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 14 608 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 14 609 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 ppm 10 14 610 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 801 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 802 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 803 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 804 93 1 Metaplasia Mild, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 805 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 806 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 807 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 808 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 809 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 810 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1004 92 1 Metaplasia Mild, Squamous Natural Death
Respiratory System Nose Respirat Epith 100 ppm 10 22 1008 91 1 Metaplasia Marked, Squamous Natural Death
Respiratory System Nose Respirat Epith 100 ppm 10 21 1001 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1002 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1003 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1005 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1006 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1007 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1009 93 1 Metaplasia Marked, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1010 93 1 Metaplasia Moderate, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 803 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 806 93 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1004 92 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 100 ppm 10 22 1008 91 1 Necrosis Moderate Natural Death
Respiratory System Nose Respirat Epith 100 ppm 10 21 1001 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1002 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1003 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1005 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1006 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1007 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1009 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1010 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 801 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 803 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 17 804 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 ppm 10 18 807 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1004 92 1 Regeneration Mild Natural Death
Respiratory System Nose Respirat Epith 100 ppm 10 22 1008 91 1 Regeneration Minimal Natural Death
Respiratory System Nose Respirat Epith 100 ppm 10 21 1001 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1002 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1003 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 21 1005 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1006 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1007 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1009 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 ppm 10 22 1010 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Nose Septum 100 ppm 10 21 1004 92 1 Necrosis Minimal Natural Death
Respiratory System Nose Turbinate 50 ppm 10 17 803 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 50 ppm 10 18 806 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 50 ppm 10 18 807 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 21 1004 92 1 Atrophy Moderate Natural Death
Respiratory System Nose Turbinate 100 ppm 10 22 1008 91 1 Atrophy Moderate Natural Death
Respiratory System Nose Turbinate 100 ppm 10 21 1001 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 21 1002 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 21 1003 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 21 1005 93 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 22 1006 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 22 1007 93 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 22 1009 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Turbinate 100 ppm 10 22 1010 93 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose 25 ppm 10 13 602 93 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 17 801 93 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 17 802 93 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 17 803 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 17 804 93 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 17 805 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 18 806 93 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 18 807 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 18 808 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 18 809 93 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Nose 50 ppm 10 18 810 93 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 21 1004 92 1 Inflammation Mild, Suppurative Natural Death
Respiratory System Nose 100 ppm 10 22 1008 91 1 Inflammation Marked, Suppurative Natural Death
Respiratory System Nose 100 ppm 10 21 1001 93 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 21 1002 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 21 1003 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 21 1005 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 22 1006 93 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 22 1007 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 22 1009 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Nose 100 ppm 10 22 1010 93 1 Inflammation Marked, Suppurative Terminal Sacrifice
Respiratory System Trachea Epithelium 50 ppm 10 17 801 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 50 ppm 10 17 804 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 21 1004 92 1 Hyperplasia Mild Natural Death
Respiratory System Trachea Epithelium 100 ppm 10 22 1007 93 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1008 91 1 Metaplasia Mild, Squamous Natural Death
Respiratory System Trachea Epithelium 100 ppm 10 21 1002 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1009 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1010 93 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 21 1004 92 1 Necrosis Marked Natural Death
Respiratory System Trachea Epithelium 100 ppm 10 22 1008 91 1 Necrosis Marked Natural Death
Respiratory System Trachea Epithelium 100 ppm 10 21 1001 93 1 Necrosis Marked Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 21 1002 93 1 Necrosis Marked Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 21 1003 93 1 Necrosis Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 21 1005 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1006 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1007 93 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1009 93 1 Necrosis Marked Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1010 93 1 Necrosis Marked Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1008 91 1 Regeneration Mild Natural Death
Respiratory System Trachea Epithelium 100 ppm 10 21 1001 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 21 1002 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 21 1003 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 21 1005 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1006 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1007 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1009 93 1 Regeneration Mild Terminal Sacrifice
Respiratory System Trachea Epithelium 100 ppm 10 22 1010 93 1 Regeneration Minimal Terminal Sacrifice
Respiratory System Trachea 100 ppm 10 22 1008 91 1 Inflammation Mild, Chronic Active Natural Death
Respiratory System Trachea 100 ppm 10 21 1001 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Special Senses System Eye Cornea 100 ppm 10 21 1004 92 1 Inflammation Mild, Acute Natural Death
Special Senses System Eye Cornea 100 ppm 10 22 1008 91 1 Inflammation Minimal, Acute Natural Death
Special Senses System Eye Cornea 50 ppm 10 18 807 93 1 Mineralization Minimal Terminal Sacrifice
Special Senses System Eye Cornea 100 ppm 10 21 1004 92 1 Neovascularization Minimal Natural Death
Urinary System Kidney Pelvis 25 ppm 2 14 610 93 1 Dilatation Mild Terminal Sacrifice
Urinary System Kidney 25 ppm 2 14 609 93 1 Cyst Moderate Terminal Sacrifice
Urinary System Kidney 25 ppm 2 14 609 93 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 100 ppm 10 21 1002 93 1 Nephropathy Minimal Terminal Sacrifice