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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: 2,3-Butanedione
CASRN: ="431-03-8"
Study Number: C20725
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 2072503
Sex: Male
Strain and Species: Wistar Han Rats

Male Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Intestine Large Cecum 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Intestine Large Colon 50 ppm 50 67 633 549 1 Carcinoma Moribund Sacrifice
Alimentary System Intestine Large Colon 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Intestine Large Rectum 12.5 ppm 50 29 241 729 1 Schwannoma Malignant Metastatic Moribund Sacrifice
Alimentary System Intestine Small Duodenum 12.5 ppm 50 29 241 729 1 Schwannoma Malignant Metastatic Moribund Sacrifice
Alimentary System Intestine Small Ileum 12.5 ppm 50 21 204 729 1 Carcinoid Tumor Benign Terminal Sacrifice
Alimentary System Intestine Small Ileum 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Intestine Small Ileum 12.5 ppm 50 29 241 729 1 Schwannoma Malignant Metastatic Moribund Sacrifice
Alimentary System Intestine Small Jejunum Vehicle Control 50 3 13 695 1 Histiocytic Sarcoma Moribund Sacrifice
Alimentary System Intestine Small Jejunum Vehicle Control 50 7 35 729 1 Leiomyoma Terminal Sacrifice
Alimentary System Liver Vehicle Control 50 3 13 695 1 Hemangioma Moribund Sacrifice
Alimentary System Liver 12.5 ppm 50 26 229 730 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 12.5 ppm 50 22 206 606 1 Histiocytic Sarcoma Moribund Sacrifice
Alimentary System Liver Vehicle Control 50 4 16 523 1 Lymphoma Malignant Natural Death
Alimentary System Liver 25 ppm 50 42 409 325 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Liver 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Liver 12.5 ppm 50 29 241 729 1 Schwannoma Malignant Metastatic Moribund Sacrifice
Alimentary System Mesentery Fat 12.5 ppm 4 27 235 586 1 Liposarcoma Metastatic Moribund Sacrifice
Alimentary System Mesentery Vehicle Control 5 3 11 729 1 Carcinosarcoma Metastatic Terminal Sacrifice
Alimentary System Mesentery 12.5 ppm 4 30 249 729 1 Hemangiosarcoma Terminal Sacrifice
Alimentary System Mesentery Vehicle Control 5 3 13 695 1 Histiocytic Sarcoma Moribund Sacrifice
Alimentary System Mesentery 25 ppm 3 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Oral Mucosa Vehicle Control 1 9 44 729 1 Squamous Cell Carcinoma Terminal Sacrifice
Alimentary System Oral Mucosa 12.5 ppm 1 22 206 606 1 Squamous Cell Carcinoma Moribund Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 50 3 11 729 1 Carcinosarcoma Metastatic Terminal Sacrifice
Alimentary System Pancreas 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Salivary Glands 12.5 ppm 50 29 244 731 1 Carcinoma Terminal Sacrifice
Alimentary System Stomach Forestomach 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Stomach Forestomach 25 ppm 50 44 420 694 1 Sarcoma Moribund Sacrifice
Alimentary System Stomach Forestomach 25 ppm 50 48 440 729 1 Squamous Cell Carcinoma Terminal Sacrifice
Alimentary System Stomach Forestomach 12.5 ppm 50 27 235 586 1 Squamous Cell Papilloma Moribund Sacrifice
Alimentary System Stomach Forestomach 25 ppm 50 45 423 722 1 Squamous Cell Papilloma Moribund Sacrifice
Alimentary System Stomach Glandular 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Alimentary System Stomach Glandular 12.5 ppm 50 29 241 729 1 Schwannoma Malignant Metastatic Moribund Sacrifice
Cardiovascular System Heart Epicardium 12.5 ppm 50 22 207 701 1 Mesothelioma Malignant Natural Death
Cardiovascular System Heart Pericardium 12.5 ppm 50 22 207 701 1 Mesothelioma Malignant Natural Death
Cardiovascular System Heart Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Cardiovascular System Heart 25 ppm 50 47 432 715 1 Neural Crest Tumor Metastatic Moribund Sacrifice
Cardiovascular System Heart 12.5 ppm 50 29 241 729 1 Schwannoma Malignant Moribund Sacrifice
Cardiovascular System Heart 12.5 ppm 50 21 203 729 1 Schwannoma Malignant Terminal Sacrifice
Cardiovascular System Heart 25 ppm 50 45 423 722 1 Schwannoma Malignant Moribund Sacrifice
Endocrine System Adrenal Cortex Vehicle Control 50 10 50 633 1 Adenoma Moribund Sacrifice
Endocrine System Adrenal Cortex Vehicle Control 50 8 40 724 1 Adenoma Moribund Sacrifice
Endocrine System Adrenal Cortex 12.5 ppm 50 24 218 633 1 Adenoma Moribund Sacrifice
Endocrine System Adrenal Cortex 12.5 ppm 50 26 229 730 1 Adenoma Terminal Sacrifice
Endocrine System Adrenal Cortex 25 ppm 50 46 427 731 1 Adenoma Terminal Sacrifice
Endocrine System Adrenal Cortex 50 ppm 50 61 603 729 1 Adenoma Terminal Sacrifice
Endocrine System Adrenal Cortex 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Endocrine System Adrenal Medulla Vehicle Control 50 8 40 724 1 Pheochromocytoma Benign Moribund Sacrifice
Endocrine System Adrenal Medulla 12.5 ppm 50 23 212 730 1 Pheochromocytoma Benign Terminal Sacrifice
Endocrine System Adrenal Medulla 12.5 ppm 50 27 232 730 1 Pheochromocytoma Benign Terminal Sacrifice
Endocrine System Adrenal Medulla 12.5 ppm 50 27 233 729 1 Pheochromocytoma Benign Terminal Sacrifice
Endocrine System Adrenal Medulla 25 ppm 50 46 430 729 1 Pheochromocytoma Benign Terminal Sacrifice
Endocrine System Adrenal Medulla 50 ppm 50 62 610 628 1 Pheochromocytoma Benign Moribund Sacrifice
Endocrine System Adrenal Medulla 50 ppm 50 66 626 712 1 Pheochromocytoma Benign Moribund Sacrifice
Endocrine System Adrenal Medulla 50 ppm 50 65 623 731 1 Pheochromocytoma Benign Terminal Sacrifice
Endocrine System Islets Pancreatic 12.5 ppm 50 24 216 730 1 Adenoma Terminal Sacrifice
Endocrine System Parathyroid Gland Bilateral 12.5 ppm 50 21 205 730 1 Adenoma Terminal Sacrifice
Endocrine System Parathyroid Gland Vehicle Control 50 10 49 729 1 Adenoma Terminal Sacrifice
Endocrine System Parathyroid Gland Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 50 1 1 486 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 50 1 2 633 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 50 2 7 379 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 50 6 30 694 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 50 7 33 724 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 50 3 15 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 50 6 27 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 50 6 28 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 50 7 35 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 21 202 600 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 22 209 656 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 23 214 633 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 24 219 682 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 25 221 711 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 25 222 611 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 30 247 640 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 21 201 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 21 205 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 23 212 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 26 227 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 26 228 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 30 248 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 12.5 ppm 50 30 250 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 25 ppm 50 42 407 582 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 25 ppm 50 43 411 527 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 25 ppm 50 43 413 543 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 25 ppm 50 43 414 592 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 25 ppm 50 45 425 617 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 25 ppm 50 47 435 695 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 25 ppm 50 49 443 589 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 25 ppm 50 50 450 561 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 25 ppm 50 45 421 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 50 ppm 50 70 647 649 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 50 ppm 50 66 627 626 1 Adenoma Natural Death
Endocrine System Pituitary Gland Pars Distalis 50 ppm 50 69 641 616 1 Adenoma Natural Death
Endocrine System Pituitary Gland Pars Distalis 50 ppm 50 68 639 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 50 ppm 50 70 649 731 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Intermed Vehicle Control 50 7 34 633 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Intermed Vehicle Control 50 10 49 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Intermed 12.5 ppm 50 22 207 701 1 Adenoma Natural Death
Endocrine System Pituitary Gland Pars Intermed 50 ppm 50 69 644 570 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Nervosa 50 ppm 50 69 642 659 1 Schwannoma Malignant Moribund Sacrifice
Endocrine System Thyroid Gland Bilateral, C Cell Vehicle Control 50 8 37 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 50 6 30 694 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 50 9 45 654 1 Adenoma Natural Death
Endocrine System Thyroid Gland C Cell Vehicle Control 50 4 17 731 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 50 5 23 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 50 6 27 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 12.5 ppm 50 21 203 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 12.5 ppm 50 22 208 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 12.5 ppm 50 23 211 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 12.5 ppm 50 28 238 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 12.5 ppm 50 28 240 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 25 ppm 50 47 432 715 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland C Cell 25 ppm 50 42 406 730 Multiple Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 25 ppm 50 43 412 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 25 ppm 50 47 434 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 50 ppm 50 64 616 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 12.5 ppm 50 27 235 586 1 Carcinoma Moribund Sacrifice
Endocrine System Thyroid Gland C Cell 25 ppm 50 45 421 729 1 Carcinoma Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel Vehicle Control 50 10 49 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel Vehicle Control 50 6 29 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 12.5 ppm 50 25 222 611 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland Follicular Cel 25 ppm 50 48 438 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 25 ppm 50 50 449 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Genital System Epididymis Vehicle Control 50 6 29 729 1 Mesothelioma Malignant Terminal Sacrifice
Genital System Epididymis 12.5 ppm 50 23 213 730 1 Mesothelioma Malignant Terminal Sacrifice
Genital System Epididymis 50 ppm 50 65 625 571 1 Mesothelioma Malignant Moribund Sacrifice
Genital System Prostate 12.5 ppm 50 22 208 730 1 Adenoma Terminal Sacrifice
Genital System Prostate Vehicle Control 50 3 11 729 1 Carcinosarcoma Terminal Sacrifice
Genital System Prostate Vehicle Control 50 4 16 523 1 Lymphoma Malignant Natural Death
Genital System Prostate 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Genital System Seminal Vesicle Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Genital System Seminal Vesicle 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Genital System Testes Interstit Cell Vehicle Control 50 6 30 694 1 Adenoma Moribund Sacrifice
Genital System Testes Interstit Cell Vehicle Control 50 10 47 731 1 Adenoma Terminal Sacrifice
Genital System Testes Interstit Cell Vehicle Control 50 8 37 730 1 Adenoma Terminal Sacrifice
Genital System Testes Interstit Cell 12.5 ppm 50 22 208 730 1 Adenoma Terminal Sacrifice
Genital System Testes Interstit Cell 12.5 ppm 50 24 216 730 1 Adenoma Terminal Sacrifice
Genital System Testes Interstit Cell 12.5 ppm 50 24 217 730 1 Adenoma Terminal Sacrifice
Genital System Testes Interstit Cell 50 ppm 50 62 607 729 1 Adenoma Terminal Sacrifice
Genital System Testes Vehicle Control 50 6 29 729 1 Mesothelioma Malignant Terminal Sacrifice
Genital System Testes 50 ppm 50 66 629 731 1 Mesothelioma Malignant Terminal Sacrifice
Hematopoietic System Bone Marrow 25 ppm 50 42 409 325 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Lymph Node Bronchial Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Lymph Node Mandibular Vehicle Control 50 4 16 523 1 Lymphoma Malignant Natural Death
Hematopoietic System Lymph Node Mandibular 25 ppm 50 42 409 325 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Lymph Node Mandibular 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Lymph Node Mandibular 50 ppm 50 62 610 628 1 Squamous Cell Carcinoma Metastatic Moribund Sacrifice
Hematopoietic System Lymph Node Mediastinal 12.5 ppm 50 25 225 730 1 Hemangiosarcoma Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Lymph Node Mediastinal 25 ppm 50 42 409 325 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Lymph Node Mediastinal 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Lymph Node Mediastinal 50 ppm 50 66 627 626 1 Lymphoma Malignant Natural Death
Hematopoietic System Lymph Node Mediastinal 12.5 ppm 50 22 207 701 1 Mesothelioma Malignant Natural Death
Hematopoietic System Lymph Node Mediastinal 25 ppm 50 50 448 537 1 Schwannoma Malignant Metastatic Natural Death
Hematopoietic System Lymph Node Mesenteric 25 ppm 50 49 445 729 1 Hemangioma Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50 ppm 50 65 621 710 1 Hemangioma Moribund Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 50 10 48 731 1 Hemangiosarcoma Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 50 9 43 729 1 Hemangiosarcoma Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 25 ppm 50 44 419 729 1 Hemangiosarcoma Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 50 3 13 695 1 Histiocytic Sarcoma Moribund Sacrifice
Hematopoietic System Lymph Node Mesenteric 25 ppm 50 42 409 325 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Lymph Node Mesenteric 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Lymph Node Mesenteric 12.5 ppm 50 29 241 729 1 Schwannoma Malignant Metastatic Moribund Sacrifice
Hematopoietic System Spleen Vehicle Control 50 9 42 731 1 Hemangiosarcoma Terminal Sacrifice
Hematopoietic System Spleen 12.5 ppm 50 22 206 606 1 Histiocytic Sarcoma Moribund Sacrifice
Hematopoietic System Spleen Vehicle Control 50 4 16 523 1 Lymphoma Malignant Natural Death
Hematopoietic System Spleen 25 ppm 50 42 409 325 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Spleen 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Thymus Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Thymus Vehicle Control 50 9 43 729 1 Lymphoma Malignant Terminal Sacrifice
Hematopoietic System Thymus 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Hematopoietic System Thymus 25 ppm 50 49 445 729 1 Lymphoma Malignant Terminal Sacrifice
Hematopoietic System Thymus 25 ppm 50 50 448 537 1 Schwannoma Malignant Natural Death
Hematopoietic System Thymus Vehicle Control 50 10 46 731 1 Thymoma Benign Terminal Sacrifice
Hematopoietic System Thymus 25 ppm 50 47 431 730 1 Thymoma Benign Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 50 7 35 729 1 Carcinoma Terminal Sacrifice
Integumentary System Skin Epidermis 12.5 ppm 50 25 225 730 1 Basal Cell Carcinoma Terminal Sacrifice
Integumentary System Skin Epidermis Vehicle Control 50 8 37 730 1 Keratoacanthoma Terminal Sacrifice
Integumentary System Skin Epidermis Vehicle Control 50 8 38 731 1 Keratoacanthoma Terminal Sacrifice
Integumentary System Skin Epidermis Vehicle Control 50 9 41 730 1 Keratoacanthoma Terminal Sacrifice
Integumentary System Skin Epidermis 12.5 ppm 50 23 211 730 1 Keratoacanthoma Terminal Sacrifice
Integumentary System Skin Epidermis 12.5 ppm 50 28 240 730 1 Keratoacanthoma Terminal Sacrifice
Integumentary System Skin Epidermis 25 ppm 50 49 441 730 1 Keratoacanthoma Terminal Sacrifice
Integumentary System Skin Epidermis 25 ppm 50 50 446 731 1 Pilomatrixoma Terminal Sacrifice
Integumentary System Skin Epidermis 25 ppm 50 42 408 730 1 Squamous Cell Carcinoma Terminal Sacrifice
Integumentary System Skin Epidermis 50 ppm 50 62 610 628 1 Squamous Cell Carcinoma Moribund Sacrifice
Integumentary System Skin Epidermis 12.5 ppm 50 21 205 730 1 Squamous Cell Papilloma Terminal Sacrifice
Integumentary System Skin Sebaceous Gl Vehicle Control 50 8 36 730 1 Adenoma Terminal Sacrifice
Integumentary System Skin Subcut Tiss 50 ppm 50 65 624 599 1 Fibrosarcoma Moribund Sacrifice
Integumentary System Skin Subcut Tiss Vehicle Control 50 2 10 432 1 Fibrous Histiocytoma Moribund Sacrifice
Integumentary System Skin Subcut Tiss 12.5 ppm 50 27 232 730 1 Fibrous Histiocytoma Terminal Sacrifice
Integumentary System Skin Subcut Tiss 25 ppm 50 43 412 729 1 Hemangioma Terminal Sacrifice
Integumentary System Skin Subcut Tiss Vehicle Control 50 8 38 731 1 Myxoma Terminal Sacrifice
Integumentary System Skin Subcut Tiss 50 ppm 50 65 621 710 1 Schwannoma Malignant Moribund Sacrifice
Integumentary System Skin 12.5 ppm 50 26 230 730 1 Trichoepithelioma Terminal Sacrifice
Musculoskeletal System Skeletal Muscle 25 ppm 4 46 427 731 1 Hemangiosarcoma Terminal Sacrifice
Musculoskeletal System Skeletal Muscle 12.5 ppm 3 22 207 701 1 Mesothelioma Malignant Natural Death
Musculoskeletal System Skeletal Muscle 12.5 ppm 3 22 206 606 1 Squamous Cell Carcinoma Metastatic Moribund Sacrifice
Nervous System Brain Vehicle Control 50 3 15 730 1 Glioma Malignant Terminal Sacrifice
Nervous System Brain 12.5 ppm 50 22 208 730 1 Glioma Malignant Terminal Sacrifice
Nervous System Brain 25 ppm 50 47 431 730 1 Glioma Malignant Terminal Sacrifice
Nervous System Brain Vehicle Control 50 10 48 731 1 Granular Cell Tumor Benign Terminal Sacrifice
Nervous System Brain Vehicle Control 50 6 29 729 1 Granular Cell Tumor Benign Terminal Sacrifice
Nervous System Brain Vehicle Control 50 7 35 729 1 Granular Cell Tumor Benign Terminal Sacrifice
Nervous System Brain 12.5 ppm 50 24 219 682 1 Granular Cell Tumor Benign Moribund Sacrifice
Nervous System Brain 12.5 ppm 50 28 236 603 1 Granular Cell Tumor Benign Moribund Sacrifice
Nervous System Brain 25 ppm 50 45 423 722 1 Granular Cell Tumor Benign Moribund Sacrifice
Nervous System Brain 25 ppm 50 45 422 731 1 Granular Cell Tumor Benign Terminal Sacrifice
Nervous System Brain 50 ppm 50 63 615 499 1 Granular Cell Tumor Benign Moribund Sacrifice
Nervous System Brain Vehicle Control 50 4 19 633 1 Granular Cell Tumor Malignant Moribund Sacrifice
Nervous System Brain 12.5 ppm 50 22 206 606 1 Squamous Cell Carcinoma Metastatic Moribund Sacrifice
Respiratory System Larynx Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Respiratory System Lung Mediastinum 25 ppm 50 49 441 730 1 Mesothelioma Malignant Terminal Sacrifice
Respiratory System Lung Mediastinum 12.5 ppm 50 29 241 729 1 Schwannoma Malignant Metastatic Moribund Sacrifice
Respiratory System Lung Vehicle Control 50 2 6 730 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung 50 ppm 50 64 619 729 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 50 3 11 729 1 Carcinosarcoma Metastatic Terminal Sacrifice
Respiratory System Lung 12.5 ppm 50 22 206 606 1 Histiocytic Sarcoma Moribund Sacrifice
Respiratory System Lung Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Respiratory System Lung 25 ppm 50 45 424 592 1 Lymphoma Malignant Moribund Sacrifice
Respiratory System Lung 12.5 ppm 50 22 207 701 1 Mesothelioma Malignant Natural Death
Respiratory System Lung 25 ppm 50 47 432 715 1 Neural Crest Tumor Metastatic Moribund Sacrifice
Respiratory System Nose Vehicle Control 50 3 14 729 1 Adenoma Terminal Sacrifice
Respiratory System Nose 50 ppm 50 68 638 674 1 Squamous Cell Carcinoma Moribund Sacrifice
Respiratory System Nose 50 ppm 50 69 641 616 1 Squamous Cell Carcinoma Natural Death
Respiratory System Nose 50 ppm 50 70 649 731 1 Squamous Cell Carcinoma Terminal Sacrifice
Respiratory System Nose 50 ppm 50 63 614 589 1 Squamous Cell Papilloma Natural Death
Respiratory System Pleura 12.5 ppm 1 22 207 701 1 Mesothelioma Malignant Natural Death
Respiratory System Trachea Vehicle Control 50 2 8 530 1 Lymphoma Malignant Moribund Sacrifice
Special Senses System Ear 25 ppm 1 47 432 715 1 Neural Crest Tumor Moribund Sacrifice
Special Senses System Eye Retina 25 ppm 50 42 409 325 1 Lymphoma Malignant Moribund Sacrifice
Special Senses System Eye Retina 12.5 ppm 50 21 203 729 1 Melanoma Malignant Terminal Sacrifice
Special Senses System Eye 12.5 ppm 50 24 219 682 1 Schwannoma Malignant Metastatic Moribund Sacrifice
Special Senses System Harderian Gland 12.5 ppm 50 24 219 682 1 Schwannoma Malignant Moribund Sacrifice
Urinary System Kidney Vehicle Control 50 3 13 695 1 Histiocytic Sarcoma Moribund Sacrifice
Urinary System Kidney 12.5 ppm 50 27 235 586 1 Liposarcoma Moribund Sacrifice
Urinary System Urinary Bladder Vehicle Control 50 4 16 523 1 Lymphoma Malignant Natural Death