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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: p-Chloro-a,a,a-trifluorotoluene
CASRN: ="98-56-6"
Study Number: C10472B
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 1047204
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
104 Vehicle Control Ulcer/Abscess Torso/Dorsal 2 11/08/2012 01/31/11 648.00 No
104 Vehicle Control Thin 11/08/2012 01/31/11 648.00 No
104 Vehicle Control Abnormal Breathing 11/30/2012 01/31/11 670.00 Yes
104 Vehicle Control Ulcer/Abscess Torso/Dorsal 1 11/30/2012 01/31/11 670.00 Yes
104 Vehicle Control Thin 11/30/2012 01/31/11 670.00 Yes
105 Vehicle Control Thin 06/21/2012 01/31/11 508.00 No
105 Vehicle Control Thin 07/19/2012 01/31/11 536.00 No
114 Vehicle Control Lethargic 12/06/2012 01/31/11 676.00 No
114 Vehicle Control Abnormal Breathing 12/06/2012 01/31/11 676.00 Yes
114 Vehicle Control Abnormal Breathing 12/06/2012 01/31/11 676.00 No
114 Vehicle Control Lethargic 12/06/2012 01/31/11 676.00 Yes
116 Vehicle Control Hyperactivity 05/13/2012 01/31/11 469.00 Yes
116 Vehicle Control Head Tilt 05/13/2012 01/31/11 469.00 Yes
118 Vehicle Control Thin 01/31/2013 01/31/11 732.00 Yes
119 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 01/03/2013 01/31/11 704.00 No
119 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 01/18/2013 01/31/11 719.00 Yes
119 Vehicle Control Mass Torso/Dorsal, Large (16mm And Larger) 1 01/18/2013 01/31/11 719.00 Yes
120 Vehicle Control Mass Torso/Lateral, Medium (6mm-15mm) 1 09/13/2012 01/31/11 592.00 No
120 Vehicle Control Mass Head, Large (16mm And Larger) 1 10/11/2012 01/31/11 620.00 No
120 Vehicle Control Mass Head, Large (16mm And Larger) 1 11/02/2012 01/31/11 642.00 Yes
121 Vehicle Control Abnormal Breathing 08/16/2012 01/31/11 564.00 Yes
121 Vehicle Control Thin 08/16/2012 01/31/11 564.00 No
121 Vehicle Control Thin 08/16/2012 01/31/11 564.00 Yes
121 Vehicle Control Abnormal Breathing 08/16/2012 01/31/11 564.00 No
131 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/19/2012 01/31/11 536.00 No
131 Vehicle Control Thin 07/27/2012 01/31/11 544.00 Yes
131 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/27/2012 01/31/11 544.00 Yes
303 100 ppm Abnormal Breathing 01/30/2013 01/31/11 731.00 Yes
305 100 ppm Abnormal Breathing 06/01/2012 01/31/11 488.00 Yes
305 100 ppm Thin 06/01/2012 01/31/11 488.00 Yes
306 100 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 10/11/2012 01/31/11 620.00 No
306 100 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 10/17/2012 01/31/11 626.00 Yes
308 100 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 12/06/2012 01/31/11 676.00 No
308 100 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 12/21/2012 01/31/11 691.00 Yes
310 100 ppm Thin 07/19/2012 01/31/11 536.00 No
310 100 ppm Head Tilt 07/19/2012 01/31/11 536.00 No
310 100 ppm Thin 08/16/2012 01/31/11 564.00 No
310 100 ppm Thin 08/16/2012 01/31/11 564.00 Yes
310 100 ppm Head Tilt 08/16/2012 01/31/11 564.00 No
310 100 ppm Head Tilt 08/16/2012 01/31/11 564.00 Yes
317 100 ppm Lethargic 09/18/2012 01/31/11 597.00 Yes
317 100 ppm Abnormal Breathing 09/18/2012 01/31/11 597.00 Yes
317 100 ppm Thin 09/18/2012 01/31/11 597.00 Yes
321 100 ppm Abnormal Breathing 09/11/2011 01/31/11 224.00 Yes
321 100 ppm Thin 09/11/2011 01/31/11 224.00 Yes
321 100 ppm Lethargic 09/11/2011 01/31/11 224.00 Yes
321 100 ppm Ruffled Fur 09/11/2011 01/31/11 224.00 Yes
324 100 ppm Abnormal Breathing 11/19/2012 01/31/11 659.00 Yes
324 100 ppm Lethargic 11/19/2012 01/31/11 659.00 Yes
327 100 ppm Abnormal Breathing 01/02/2013 01/31/11 703.00 Yes
327 100 ppm Thin 01/02/2013 01/31/11 703.00 Yes
332 100 ppm Thin 12/06/2012 01/31/11 676.00 No
332 100 ppm Thin 12/20/2012 01/31/11 690.00 Yes
337 100 ppm Eye Abnormality 09/13/2012 01/31/11 592.00 No
337 100 ppm Eye Abnormality 10/11/2012 01/31/11 620.00 No
337 100 ppm Eye Abnormality 11/08/2012 01/31/11 648.00 No
337 100 ppm Eye Abnormality 12/06/2012 01/31/11 676.00 No
337 100 ppm Eye Abnormality 01/03/2013 01/31/11 704.00 No
337 100 ppm Eye Abnormality 01/31/2013 01/31/11 732.00 Yes
340 100 ppm Abnormal Breathing 10/02/2012 01/31/11 611.00 Yes
340 100 ppm Ulcer/Abscess Head 1 10/02/2012 01/31/11 611.00 Yes
341 100 ppm Thin 02/01/2013 01/31/11 733.00 Yes
342 100 ppm Thin 12/06/2012 01/31/11 676.00 No
342 100 ppm Thin 01/03/2013 01/31/11 704.00 No
342 100 ppm Abnormal Breathing 01/03/2013 01/31/11 704.00 No
342 100 ppm Thin 01/03/2013 01/31/11 704.00 Yes
342 100 ppm Abnormal Breathing 01/03/2013 01/31/11 704.00 Yes
343 100 ppm Mass Torso/Dorsal, Large (16mm And Larger) 1 11/08/2012 01/31/11 648.00 No
343 100 ppm Thin 11/08/2012 01/31/11 648.00 No
343 100 ppm Thin 11/14/2012 01/31/11 654.00 Yes
343 100 ppm Abnormal Breathing 11/14/2012 01/31/11 654.00 Yes
343 100 ppm Mass Torso/Dorsal, Large (16mm And Larger) 1 11/14/2012 01/31/11 654.00 Yes
344 100 ppm Thin 11/08/2012 01/31/11 648.00 No
345 100 ppm Thin 08/16/2012 01/31/11 564.00 No
345 100 ppm Thin 09/13/2012 01/31/11 592.00 No
345 100 ppm Thin 10/11/2012 01/31/11 620.00 No
345 100 ppm Thin 11/08/2012 01/31/11 648.00 No
345 100 ppm Thin 12/06/2012 01/31/11 676.00 No
345 100 ppm Thin 01/03/2013 01/31/11 704.00 No
345 100 ppm Thin 02/01/2013 01/31/11 733.00 Yes
346 100 ppm Clonic Seizures 07/28/2012 01/31/11 545.00 Yes
346 100 ppm Lethargic 07/28/2012 01/31/11 545.00 Yes
348 100 ppm Thin 01/05/2012 01/31/11 340.00 No
504 200 ppm Thin 11/08/2012 01/31/11 648.00 No
504 200 ppm Thin 12/06/2012 01/31/11 676.00 No
504 200 ppm Thin 01/03/2013 01/31/11 704.00 No
504 200 ppm Thin 02/01/2013 01/31/11 733.00 Yes
505 200 ppm Eye Abnormality 08/16/2012 01/31/11 564.00 No
505 200 ppm Eye Abnormality 09/13/2012 01/31/11 592.00 No
505 200 ppm Thin 09/25/2012 01/31/11 604.00 Yes
505 200 ppm Eye Abnormality 09/25/2012 01/31/11 604.00 Yes
507 200 ppm Thin 06/16/2012 01/31/11 503.00 Yes
507 200 ppm Ataxia 06/16/2012 01/31/11 503.00 Yes
507 200 ppm Lethargic 06/16/2012 01/31/11 503.00 Yes
507 200 ppm Abnormal Breathing 06/16/2012 01/31/11 503.00 Yes
512 200 ppm Thin 06/21/2012 01/31/11 508.00 No
512 200 ppm Thin 07/19/2012 01/31/11 536.00 No
512 200 ppm Thin 08/16/2012 01/31/11 564.00 No
512 200 ppm Thin 08/28/2012 01/31/11 576.00 Yes
512 200 ppm Abnormal Breathing 08/28/2012 01/31/11 576.00 Yes
518 200 ppm Clonic Seizures 06/23/2011 01/31/11 144.00 No
518 200 ppm Thin 07/27/2012 01/31/11 544.00 Yes
518 200 ppm Abnormal Breathing 07/27/2012 01/31/11 544.00 Yes
520 200 ppm Thin 02/01/2013 01/31/11 733.00 Yes
521 200 ppm Nasal/Eye Discharge 01/28/2013 01/31/11 729.00 Yes
522 200 ppm Thin 01/03/2013 01/31/11 704.00 No
522 200 ppm Thin 01/22/2013 01/31/11 723.00 Yes
526 200 ppm Lethargic 08/14/2012 01/31/11 562.00 Yes
535 200 ppm Lethargic 09/16/2012 01/31/11 595.00 Yes
535 200 ppm Abnormal Breathing 09/16/2012 01/31/11 595.00 Yes
536 200 ppm Eye Abnormality 07/19/2012 01/31/11 536.00 No
536 200 ppm Eye Abnormality 08/16/2012 01/31/11 564.00 No
536 200 ppm Eye Abnormality 09/13/2012 01/31/11 592.00 No
536 200 ppm Eye Abnormality 10/11/2012 01/31/11 620.00 No
536 200 ppm Eye Abnormality 11/08/2012 01/31/11 648.00 No
536 200 ppm Eye Abnormality 12/06/2012 01/31/11 676.00 No
536 200 ppm Eye Abnormality 01/03/2013 01/31/11 704.00 No
536 200 ppm Eye Abnormality 01/30/2013 01/31/11 731.00 Yes
540 200 ppm Abnormal Breathing 11/01/2012 01/31/11 641.00 Yes
546 200 ppm Abnormal Breathing 07/09/2012 01/31/11 526.00 Yes
547 200 ppm Eye Abnormality 02/01/2013 01/31/11 733.00 Yes
550 200 ppm Mass Torso/Lateral, Medium (6mm-15mm) 1 03/29/2012 01/31/11 424.00 No
550 200 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 04/26/2012 01/31/11 452.00 No
550 200 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 05/24/2012 01/31/11 480.00 Yes
550 200 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 05/24/2012 01/31/11 480.00 No
702 400 ppm Lethargic 09/17/2012 01/31/11 596.00 Yes
702 400 ppm Abnormal Breathing 09/17/2012 01/31/11 596.00 Yes
703 400 ppm Eye Abnormality 06/21/2012 01/31/11 508.00 No
703 400 ppm Eye Abnormality 07/19/2012 01/31/11 536.00 No
703 400 ppm Eye Abnormality 08/16/2012 01/31/11 564.00 No
703 400 ppm Eye Abnormality 09/13/2012 01/31/11 592.00 No
703 400 ppm Eye Abnormality 10/11/2012 01/31/11 620.00 No
703 400 ppm Eye Abnormality 11/08/2012 01/31/11 648.00 No
703 400 ppm Eye Abnormality 12/06/2012 01/31/11 676.00 No
703 400 ppm Eye Abnormality 01/03/2013 01/31/11 704.00 No
703 400 ppm Eye Abnormality 02/01/2013 01/31/11 733.00 Yes
706 400 ppm Abnormal Breathing 01/23/2013 01/31/11 724.00 Yes
706 400 ppm Lethargic 01/23/2013 01/31/11 724.00 Yes
707 400 ppm Abnormal Breathing 10/19/2012 01/31/11 628.00 Yes
707 400 ppm Thin 10/19/2012 01/31/11 628.00 Yes
711 400 ppm Lethargic 01/15/2013 01/31/11 716.00 Yes
711 400 ppm Ataxia 01/15/2013 01/31/11 716.00 Yes
711 400 ppm Abnormal Breathing 01/15/2013 01/31/11 716.00 Yes
712 400 ppm Thin 02/02/2012 01/31/11 368.00 No
712 400 ppm Mass Torso/Ventral, Medium (6mm-15mm) 3 02/02/2012 01/31/11 368.00 No
712 400 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 02/02/2012 01/31/11 368.00 No
712 400 ppm Thin 02/08/2012 01/31/11 374.00 Yes
712 400 ppm Mass Torso/Ventral, Large (16mm And Larger) 1 02/08/2012 01/31/11 374.00 Yes
715 400 ppm Lethargic 12/03/2012 01/31/11 673.00 Yes
715 400 ppm Abnormal Breathing 12/03/2012 01/31/11 673.00 Yes
716 400 ppm Eye Abnormality 09/13/2012 01/31/11 592.00 No
716 400 ppm Eye Abnormality 10/11/2012 01/31/11 620.00 No
716 400 ppm Eye Abnormality 11/08/2012 01/31/11 648.00 No
716 400 ppm Eye Abnormality 12/06/2012 01/31/11 676.00 No
716 400 ppm Eye Abnormality 01/03/2013 01/31/11 704.00 No
716 400 ppm Eye Abnormality 01/31/2013 01/31/11 732.00 Yes
717 400 ppm Abnormal Breathing 07/13/2012 01/31/11 530.00 Yes
717 400 ppm Thin 07/13/2012 01/31/11 530.00 Yes
717 400 ppm Head Tilt 07/13/2012 01/31/11 530.00 Yes
722 400 ppm Thin 12/06/2012 01/31/11 676.00 No
722 400 ppm Thin 01/03/2013 01/31/11 704.00 No
722 400 ppm Thin 01/18/2013 01/31/11 719.00 Yes
723 400 ppm Abnormal Breathing 10/11/2012 01/31/11 620.00 No
723 400 ppm Thin 10/11/2012 01/31/11 620.00 No
723 400 ppm Thin 11/08/2012 01/31/11 648.00 No
723 400 ppm Abnormal Breathing 11/08/2012 01/31/11 648.00 Yes
723 400 ppm Abnormal Breathing 11/08/2012 01/31/11 648.00 No
723 400 ppm Thin 11/08/2012 01/31/11 648.00 Yes
725 400 ppm Thin 05/24/2012 01/31/11 480.00 No
725 400 ppm Thin 05/24/2012 01/31/11 480.00 Yes
725 400 ppm Abnormal Breathing 05/24/2012 01/31/11 480.00 Yes
725 400 ppm Abnormal Breathing 05/24/2012 01/31/11 480.00 No
727 400 ppm Thin 11/08/2012 01/31/11 648.00 No
727 400 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 11/08/2012 01/31/11 648.00 No
727 400 ppm Mass Torso/Lateral, Large (16mm And Larger) 1 11/29/2012 01/31/11 669.00 Yes
727 400 ppm Thin 11/29/2012 01/31/11 669.00 Yes
728 400 ppm Thin 12/06/2012 01/31/11 676.00 No
728 400 ppm Thin 01/03/2013 01/31/11 704.00 No
728 400 ppm Thin 01/31/2013 01/31/11 732.00 Yes
729 400 ppm Thin 03/01/2012 01/31/11 396.00 No
729 400 ppm Thin 03/29/2012 01/31/11 424.00 No
729 400 ppm Thin 04/26/2012 01/31/11 452.00 No
729 400 ppm Thin 05/24/2012 01/31/11 480.00 No
729 400 ppm Thin 01/31/2013 01/31/11 732.00 Yes
730 400 ppm Thin 01/31/2013 01/31/11 732.00 Yes
730 400 ppm Abnormal Breathing 01/31/2013 01/31/11 732.00 Yes
730 400 ppm Lethargic 01/31/2013 01/31/11 732.00 Yes
734 400 ppm Thin 11/12/2012 01/31/11 652.00 Yes
734 400 ppm Lethargic 11/12/2012 01/31/11 652.00 Yes
734 400 ppm Abnormal Breathing 11/12/2012 01/31/11 652.00 Yes
735 400 ppm Clonic Seizures 06/23/2011 01/31/11 144.00 No
738 400 ppm Thin 11/08/2012 01/31/11 648.00 No
738 400 ppm Thin 11/23/2012 01/31/11 663.00 Yes
742 400 ppm Clonic Seizures 08/18/2011 01/31/11 200.00 No
743 400 ppm Thin 08/16/2012 01/31/11 564.00 No
743 400 ppm Abnormal Breathing 08/22/2012 01/31/11 570.00 Yes
743 400 ppm Thin 08/22/2012 01/31/11 570.00 Yes
745 400 ppm Abnormal Breathing 01/22/2013 01/31/11 723.00 Yes
749 400 ppm Clonic Seizures 06/23/2011 01/31/11 144.00 No
750 400 ppm Thin 11/02/2012 01/31/11 642.00 Yes
750 400 ppm Ulcer/Abscess Torso/Lateral 1 11/02/2012 01/31/11 642.00 Yes
750 400 ppm Abnormal Breathing 11/02/2012 01/31/11 642.00 Yes