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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Acetoin
CASRN: ="513-86-0"
Study Number: C20724
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 2072403
Sex: Male
Strain and Species: Wistar Han Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver 50 ppm 1 6 208 93 1 Atrophy Minimal Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 2 8 93 1 Atrophy Mild Terminal Sacrifice
Alimentary System Pancreas Vehicle Control 10 2 7 93 1 Atrophy Minimal Terminal Sacrifice
Alimentary System Pancreas 800 ppm 10 21 1004 93 1 Atrophy Minimal Terminal Sacrifice
Cardiovascular System Heart 800 ppm 10 21 1003 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 800 ppm 10 22 1006 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 800 ppm 10 22 1010 93 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 10 93 1 Necrosis Minimal, Acute Terminal Sacrifice
Endocrine System Pituitary Gland 800 ppm 10 21 1001 93 1 Cyst Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 1 5 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Hematopoietic System Spleen 800 ppm 10 22 1009 93 1 Accessory Spleen Terminal Sacrifice
Respiratory System Larynx Squam Epithel 800 ppm 10 22 1010 93 1 Erosion Minimal Terminal Sacrifice
Respiratory System Larynx Squam Epithel Vehicle Control 10 1 3 93 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Larynx Vehicle Control 10 2 8 93 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Larynx 800 ppm 10 21 1002 93 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Larynx 800 ppm 10 22 1006 93 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Larynx 800 ppm 10 22 1010 93 1 Inflammation Minimal, Acute Terminal Sacrifice
Respiratory System Lung 800 ppm 10 22 1007 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 800 ppm 10 22 1010 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 800 ppm 10 21 1003 93 1 Metaplasia, Osseous Minimal, Osseous Terminal Sacrifice
Urinary System Kidney Cortex Vehicle Control 10 1 2 93 1 Cyst Minimal Terminal Sacrifice
Urinary System Kidney Pelvis Vehicle Control 10 1 5 93 1 Dilatation Marked Terminal Sacrifice
Urinary System Kidney Pelvis 200 ppm 2 13 605 93 1 Dilatation Moderate Terminal Sacrifice
Urinary System Kidney Pelvis 200 ppm 2 14 610 93 1 Dilatation Moderate Terminal Sacrifice
Urinary System Kidney Pelvis 800 ppm 10 22 1008 93 1 Dilatation Mild Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 2 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 5 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 800 ppm 10 21 1002 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 800 ppm 10 21 1004 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 800 ppm 10 22 1010 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Urinary Bladder 100 ppm 1 10 406 93 1 Calculus Gross Observation Terminal Sacrifice
Urinary System Urinary Bladder 200 ppm 1 14 606 93 1 Calculus Gross Observation Terminal Sacrifice