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Current Search Critera

Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: 2,3-Pentanedione
CASRN: ="600-14-6"
Study Number: C08010
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 0801001
Sex: Male
Strain and Species: Wistar Han Rats

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
201 6.25 ppm Ulcer/Abscess Torso/Ventral 1 10/01/2010 9/13/10 19.00 No
201 6.25 ppm Ulcer/Abscess Torso/Lateral 1 10/01/2010 9/13/10 19.00 No
201 6.25 ppm Ulcer/Abscess Torso/Ventral 1 10/15/2010 9/13/10 33.00 No
201 6.25 ppm Ulcer/Abscess Torso/Lateral 1 10/22/2010 9/13/10 40.00 No
201 6.25 ppm Ulcer/Abscess Torso/Lateral 1 10/29/2010 9/13/10 47.00 No
605 25 ppm Ulcer/Abscess Torso/Lateral 1 10/15/2010 9/13/10 33.00 No
801 50 ppm Sneezing 11/26/2010 9/13/10 75.00 No
802 50 ppm Abnormal Breathing 10/08/2010 9/13/10 26.00 No
802 50 ppm Sneezing 10/08/2010 9/13/10 26.00 No
802 50 ppm Abnormal Breathing 12/03/2010 9/13/10 82.00 No
802 50 ppm Abnormal Breathing 12/10/2010 9/13/10 89.00 No
802 50 ppm Abnormal Breathing 12/14/2010 9/13/10 93.00 Yes
803 50 ppm Sneezing 10/08/2010 9/13/10 26.00 No
803 50 ppm Sneezing 10/22/2010 9/13/10 40.00 No
803 50 ppm Sneezing 12/10/2010 9/13/10 89.00 No
803 50 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
804 50 ppm Abnormal Breathing 10/01/2010 9/13/10 19.00 No
804 50 ppm Sneezing 10/22/2010 9/13/10 40.00 No
804 50 ppm Sneezing 11/05/2010 9/13/10 54.00 No
804 50 ppm Eye Abnormality 11/19/2010 9/13/10 68.00 No
804 50 ppm Eye Abnormality 11/26/2010 9/13/10 75.00 No
805 50 ppm Sneezing 11/12/2010 9/13/10 61.00 No
805 50 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
806 50 ppm Sneezing 10/08/2010 9/13/10 26.00 No
806 50 ppm Sneezing 10/15/2010 9/13/10 33.00 No
806 50 ppm Sneezing 10/29/2010 9/13/10 47.00 No
806 50 ppm Sneezing 11/12/2010 9/13/10 61.00 No
806 50 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
807 50 ppm Sneezing 10/15/2010 9/13/10 33.00 No
807 50 ppm Eye Abnormality 11/19/2010 9/13/10 68.00 No
807 50 ppm Eye Abnormality 11/26/2010 9/13/10 75.00 No
807 50 ppm Sneezing 11/26/2010 9/13/10 75.00 No
807 50 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
808 50 ppm Sneezing 10/08/2010 9/13/10 26.00 No
808 50 ppm Sneezing 10/29/2010 9/13/10 47.00 No
808 50 ppm Eye Abnormality 11/12/2010 9/13/10 61.00 No
808 50 ppm Eye Abnormality 11/19/2010 9/13/10 68.00 No
808 50 ppm Eye Abnormality 11/26/2010 9/13/10 75.00 No
808 50 ppm Eye Abnormality 12/03/2010 9/13/10 82.00 No
808 50 ppm Eye Abnormality 12/10/2010 9/13/10 89.00 No
808 50 ppm Sneezing 12/10/2010 9/13/10 89.00 No
808 50 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
808 50 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
809 50 ppm Sneezing 11/19/2010 9/13/10 68.00 No
809 50 ppm Sneezing 11/26/2010 9/13/10 75.00 No
809 50 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
810 50 ppm Eye Abnormality 11/19/2010 9/13/10 68.00 No
810 50 ppm Eye Abnormality 11/26/2010 9/13/10 75.00 No
810 50 ppm Eye Abnormality 12/03/2010 9/13/10 82.00 No
810 50 ppm Eye Abnormality 12/10/2010 9/13/10 89.00 No
810 50 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
1001 100 ppm Sneezing 10/08/2010 9/13/10 26.00 No
1001 100 ppm Sneezing 10/15/2010 9/13/10 33.00 No
1001 100 ppm Sneezing 10/22/2010 9/13/10 40.00 No
1001 100 ppm Sneezing 10/29/2010 9/13/10 47.00 No
1001 100 ppm Sneezing 11/05/2010 9/13/10 54.00 No
1001 100 ppm Sneezing 11/12/2010 9/13/10 61.00 No
1001 100 ppm Sneezing 11/19/2010 9/13/10 68.00 No
1001 100 ppm Sneezing 11/26/2010 9/13/10 75.00 No
1001 100 ppm Sneezing 12/03/2010 9/13/10 82.00 No
1001 100 ppm Sneezing 12/10/2010 9/13/10 89.00 No
1001 100 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
1002 100 ppm Sneezing 11/05/2010 9/13/10 54.00 No
1002 100 ppm Sneezing 11/12/2010 9/13/10 61.00 No
1002 100 ppm Sneezing 11/19/2010 9/13/10 68.00 No
1002 100 ppm Sneezing 11/26/2010 9/13/10 75.00 No
1002 100 ppm Abnormal Breathing 12/10/2010 9/13/10 89.00 No
1002 100 ppm Sneezing 12/10/2010 9/13/10 89.00 No
1002 100 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
1002 100 ppm Abnormal Breathing 12/14/2010 9/13/10 93.00 Yes
1003 100 ppm Sneezing 10/29/2010 9/13/10 47.00 No
1003 100 ppm Sneezing 11/19/2010 9/13/10 68.00 No
1003 100 ppm Eye Abnormality 11/26/2010 9/13/10 75.00 No
1003 100 ppm Eye Abnormality 12/03/2010 9/13/10 82.00 No
1003 100 ppm Sneezing 12/03/2010 9/13/10 82.00 No
1003 100 ppm Eye Abnormality 12/10/2010 9/13/10 89.00 No
1003 100 ppm Sneezing 12/10/2010 9/13/10 89.00 No
1003 100 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
1003 100 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
1004 100 ppm Sneezing 10/08/2010 9/13/10 26.00 No
1004 100 ppm Sneezing 10/22/2010 9/13/10 40.00 No
1004 100 ppm Sneezing 11/05/2010 9/13/10 54.00 No
1004 100 ppm Sneezing 11/19/2010 9/13/10 68.00 No
1004 100 ppm Sneezing 11/26/2010 9/13/10 75.00 No
1004 100 ppm Sneezing 12/03/2010 9/13/10 82.00 No
1004 100 ppm Eye Abnormality 12/10/2010 9/13/10 89.00 No
1004 100 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
1004 100 ppm Abnormal Breathing 12/14/2010 9/13/10 93.00 Yes
1004 100 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
1005 100 ppm Sneezing 10/08/2010 9/13/10 26.00 No
1005 100 ppm Sneezing 10/15/2010 9/13/10 33.00 No
1005 100 ppm Sneezing 10/22/2010 9/13/10 40.00 No
1005 100 ppm Sneezing 10/29/2010 9/13/10 47.00 No
1005 100 ppm Sneezing 11/05/2010 9/13/10 54.00 No
1005 100 ppm Sneezing 11/12/2010 9/13/10 61.00 No
1005 100 ppm Sneezing 11/19/2010 9/13/10 68.00 No
1005 100 ppm Sneezing 11/26/2010 9/13/10 75.00 No
1005 100 ppm Sneezing 12/10/2010 9/13/10 89.00 No
1005 100 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
1006 100 ppm Sneezing 10/29/2010 9/13/10 47.00 No
1006 100 ppm Sneezing 11/05/2010 9/13/10 54.00 No
1006 100 ppm Eye Abnormality 11/12/2010 9/13/10 61.00 No
1006 100 ppm Eye Abnormality 11/19/2010 9/13/10 68.00 No
1006 100 ppm Eye Abnormality 11/26/2010 9/13/10 75.00 No
1006 100 ppm Sneezing 12/03/2010 9/13/10 82.00 No
1006 100 ppm Eye Abnormality 12/03/2010 9/13/10 82.00 No
1006 100 ppm Sneezing 12/10/2010 9/13/10 89.00 No
1006 100 ppm Abnormal Breathing 12/10/2010 9/13/10 89.00 No
1006 100 ppm Eye Abnormality 12/10/2010 9/13/10 89.00 No
1006 100 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
1006 100 ppm Abnormal Breathing 12/14/2010 9/13/10 93.00 Yes
1006 100 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
1007 100 ppm Sneezing 10/08/2010 9/13/10 26.00 No
1007 100 ppm Sneezing 10/15/2010 9/13/10 33.00 No
1007 100 ppm Sneezing 11/05/2010 9/13/10 54.00 No
1007 100 ppm Sneezing 11/12/2010 9/13/10 61.00 No
1007 100 ppm Sneezing 11/19/2010 9/13/10 68.00 No
1007 100 ppm Sneezing 11/26/2010 9/13/10 75.00 No
1007 100 ppm Eye Abnormality 12/10/2010 9/13/10 89.00 No
1007 100 ppm Sneezing 12/10/2010 9/13/10 89.00 No
1007 100 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
1007 100 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
1008 100 ppm Sneezing 10/29/2010 9/13/10 47.00 No
1008 100 ppm Sneezing 11/05/2010 9/13/10 54.00 No
1008 100 ppm Eye Abnormality 11/12/2010 9/13/10 61.00 No
1008 100 ppm Eye Abnormality 11/19/2010 9/13/10 68.00 No
1008 100 ppm Sneezing 11/19/2010 9/13/10 68.00 No
1008 100 ppm Sneezing 11/26/2010 9/13/10 75.00 No
1008 100 ppm Eye Abnormality 11/26/2010 9/13/10 75.00 No
1008 100 ppm Eye Abnormality 12/03/2010 9/13/10 82.00 No
1008 100 ppm Abnormal Breathing 12/10/2010 9/13/10 89.00 No
1008 100 ppm Eye Abnormality 12/10/2010 9/13/10 89.00 No
1008 100 ppm Abnormal Breathing 12/14/2010 9/13/10 93.00 Yes
1008 100 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
1009 100 ppm Sneezing 10/08/2010 9/13/10 26.00 No
1009 100 ppm Sneezing 10/22/2010 9/13/10 40.00 No
1009 100 ppm Abnormal Breathing 10/22/2010 9/13/10 40.00 No
1009 100 ppm Sneezing 10/29/2010 9/13/10 47.00 No
1009 100 ppm Abnormal Breathing 10/29/2010 9/13/10 47.00 No
1009 100 ppm Sneezing 11/05/2010 9/13/10 54.00 No
1009 100 ppm Abnormal Breathing 11/05/2010 9/13/10 54.00 No
1009 100 ppm Sneezing 11/12/2010 9/13/10 61.00 No
1009 100 ppm Abnormal Breathing 11/12/2010 9/13/10 61.00 No
1009 100 ppm Sneezing 11/19/2010 9/13/10 68.00 No
1009 100 ppm Eye Abnormality 11/19/2010 9/13/10 68.00 No
1009 100 ppm Eye Abnormality 11/26/2010 9/13/10 75.00 No
1009 100 ppm Sneezing 11/26/2010 9/13/10 75.00 No
1009 100 ppm Sneezing 12/03/2010 9/13/10 82.00 No
1009 100 ppm Eye Abnormality 12/03/2010 9/13/10 82.00 No
1009 100 ppm Abnormal Breathing 12/10/2010 9/13/10 89.00 No
1009 100 ppm Sneezing 12/10/2010 9/13/10 89.00 No
1009 100 ppm Eye Abnormality 12/10/2010 9/13/10 89.00 No
1009 100 ppm Abnormal Breathing 12/14/2010 9/13/10 93.00 Yes
1009 100 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes
1009 100 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
1010 100 ppm Sneezing 10/29/2010 9/13/10 47.00 No
1010 100 ppm Sneezing 11/05/2010 9/13/10 54.00 No
1010 100 ppm Eye Abnormality 11/12/2010 9/13/10 61.00 No
1010 100 ppm Eye Abnormality 11/19/2010 9/13/10 68.00 No
1010 100 ppm Eye Abnormality 11/26/2010 9/13/10 75.00 No
1010 100 ppm Sneezing 11/26/2010 9/13/10 75.00 No
1010 100 ppm Eye Abnormality 12/03/2010 9/13/10 82.00 No
1010 100 ppm Sneezing 12/10/2010 9/13/10 89.00 No
1010 100 ppm Eye Abnormality 12/10/2010 9/13/10 89.00 No
1010 100 ppm Eye Abnormality 12/14/2010 9/13/10 93.00 Yes
1010 100 ppm Sneezing 12/14/2010 9/13/10 93.00 Yes