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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Perfluorooctane Sulfonate
CASRN: ="1763-23-1"
Study Number: C20617
Exposure Route: GAVAGE
TDMS Number: 2061701
Sex: Female
Strain and Species: HSD Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus Vehicle Control 10 61 364 29 1 Degeneration Minimal Terminal Sacrifice
Alimentary System Esophagus Vehicle Control 10 61 364 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 67 395 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 68 396 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 68 397 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 70 406 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 70 407 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 70 408 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 70 409 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 70 410 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 415 25 1 Cytoplasmic Alteration Minimal Natural Death
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 411 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 412 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 413 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 414 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 416 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 417 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 418 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 419 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 420 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 67 395 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 68 399 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 70 406 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 70 409 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 70 410 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 415 25 1 Hypertrophy Mild Natural Death
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 411 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 412 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 413 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 71 414 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 416 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 417 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 418 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 419 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 mg/kg 10 72 420 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte Vehicle Control 10 62 366 29 1 Necrosis Marked, Diffuse Terminal Sacrifice
Alimentary System Liver .312 mg/kg 10 64 376 29 1 Clear Cell Focus Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 62 366 29 1 Congestion Marked, Diffuse Terminal Sacrifice
Alimentary System Liver .312 mg/kg 10 64 376 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .312 mg/kg 10 64 378 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .312 mg/kg 10 64 380 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .625 mg/kg 10 65 381 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .625 mg/kg 10 65 385 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver .625 mg/kg 10 66 388 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 1.25 mg/kg 10 67 391 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 1.25 mg/kg 10 67 392 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 1.25 mg/kg 10 67 394 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 2.5 mg/kg 10 69 405 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 2.5 mg/kg 10 70 409 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 5 mg/kg 10 71 412 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Stomach, Forestomach 5 mg/kg 10 71 415 25 1 Hyperkeratosis Minimal Natural Death
Cardiovascular System Heart Vehicle Control 10 62 367 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Genital System Uterus Bilateral Vehicle Control 10 62 369 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral Vehicle Control 10 62 370 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral 5 mg/kg 10 72 418 29 1 Dilation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow .312 mg/kg 10 64 376 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow .312 mg/kg 10 64 378 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow .625 mg/kg 10 66 389 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 1.25 mg/kg 10 67 392 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 69 402 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 69 403 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 69 404 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 70 406 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 70 409 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 71 415 25 1 Hypocellularity Moderate Natural Death
Hematopoietic System Bone Marrow 5 mg/kg 10 71 411 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 71 412 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 71 413 29 1 Hypocellularity Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 72 416 29 1 Hypocellularity Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 72 417 29 1 Hypocellularity Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 72 418 29 1 Hypocellularity Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 72 419 29 1 Hypocellularity Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 5 mg/kg 10 72 420 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 61 362 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 61 364 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen .312 mg/kg 10 63 371 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen .312 mg/kg 10 63 372 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen .312 mg/kg 10 63 374 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen .625 mg/kg 10 65 381 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen .625 mg/kg 10 66 389 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen .625 mg/kg 10 66 390 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 67 391 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 67 392 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 67 393 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 67 395 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 68 397 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 68 398 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 68 399 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 1.25 mg/kg 10 68 400 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 69 401 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 69 402 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 69 403 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 69 404 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 69 405 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 70 406 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 70 407 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 70 408 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 70 409 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 2.5 mg/kg 10 70 410 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 71 415 25 1 Extramedullary Hematopoiesis Minimal, Decreased Natural Death
Hematopoietic System Spleen 5 mg/kg 10 71 411 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 71 412 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 71 413 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 71 414 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 72 416 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 72 417 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 72 418 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 72 419 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Spleen 5 mg/kg 10 72 420 29 1 Extramedullary Hematopoiesis Minimal, Decreased Terminal Sacrifice
Hematopoietic System Thymus 5 mg/kg 10 71 415 25 1 Atrophy Moderate Natural Death
Respiratory System Lung 5 mg/kg 10 71 413 29 1 Inflammation Moderate, Focal, Granulomatous Terminal Sacrifice
Respiratory System Nose Respirat Epith 2.5 mg/kg 10 69 401 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Urinary System Kidney Renal Tubule .312 mg/kg 10 63 372 29 1 Mineral Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule .625 mg/kg 10 66 387 29 1 Mineral Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 1.25 mg/kg 10 68 397 29 1 Mineral Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 5 mg/kg 10 72 416 29 1 Mineral Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 62 366 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 62 369 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .312 mg/kg 10 64 378 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .625 mg/kg 10 66 386 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney .625 mg/kg 10 66 388 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 67 391 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 68 398 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 68 399 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 2.5 mg/kg 10 69 401 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 5 mg/kg 10 71 411 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 5 mg/kg 10 71 414 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice