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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Perfluorobutane sulfonate (PFBS)
CASRN: ="375-73-5"
Study Number: C07040
Exposure Route: GAVAGE
TDMS Number: 0704001
Sex: Male
Strain and Species: HSD Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus 1000 mg/kg 10 36 210 6 1 Hemorrhage Moderate Dosing Accident
Alimentary System Esophagus 500 mg/kg 10 33 191 29 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Esophagus 1000 mg/kg 10 36 206 25 1 Inflammation Mild, Chronic Natural Death
Alimentary System Esophagus 1000 mg/kg 10 36 210 6 1 Perforation Moderate Dosing Accident
Alimentary System Intestine Large Colon Vehicle Control 10 25 155 29 1 Infiltration Cellular Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 125 mg/kg 10 30 176 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 191 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 192 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 193 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 194 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 195 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 196 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 197 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 198 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 199 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 200 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 201 15 1 Cytoplasmic Alteration Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 202 18 1 Cytoplasmic Alteration Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 203 25 1 Cytoplasmic Alteration Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 204 24 1 Cytoplasmic Alteration Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 205 18 1 Cytoplasmic Alteration Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 36 206 25 1 Cytoplasmic Alteration Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 36 207 21 1 Cytoplasmic Alteration Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 36 208 18 1 Cytoplasmic Alteration Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 36 209 17 1 Cytoplasmic Alteration Minimal Natural Death
Alimentary System Liver Hepatocyte 125 mg/kg 10 29 171 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 125 mg/kg 10 29 172 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 125 mg/kg 10 29 173 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 125 mg/kg 10 29 174 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 125 mg/kg 10 29 175 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 125 mg/kg 10 30 176 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 125 mg/kg 10 30 177 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 125 mg/kg 10 30 178 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 125 mg/kg 10 30 180 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 31 181 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 31 182 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 31 183 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 31 184 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 31 185 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 32 186 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 32 187 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 32 188 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 32 189 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 250 mg/kg 10 32 190 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 191 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 192 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 193 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 194 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 33 195 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 196 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 197 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 198 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 199 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 34 200 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 201 15 1 Hypertrophy Moderate Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 202 18 1 Hypertrophy Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 203 25 1 Hypertrophy Moderate Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 204 24 1 Hypertrophy Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 35 205 18 1 Hypertrophy Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 36 206 25 1 Hypertrophy Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 36 207 21 1 Hypertrophy Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 36 208 18 1 Hypertrophy Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 36 209 17 1 Hypertrophy Mild Natural Death
Alimentary System Liver 1000 mg/kg 10 35 202 18 1 Hemorrhage Mild Natural Death
Alimentary System Liver 62.6 mg/kg 10 28 170 29 1 Hepatodiaphragmatic Nodule Minimal Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 36 207 21 1 Hepatodiaphragmatic Nodule Mild Natural Death
Alimentary System Liver Vehicle Control 10 25 154 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 25 155 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 62.6 mg/kg 10 27 165 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 29 173 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 29 174 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 31 184 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 31 185 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 32 188 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 33 194 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 35 202 18 1 Necrosis Moderate Natural Death
Alimentary System Stomach, Forestomach Epithelium 500 mg/kg 10 33 191 29 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach, Forestomach Epithelium 1000 mg/kg 10 36 210 6 1 Hyperplasia Mild Dosing Accident
Alimentary System Stomach, Forestomach Epithelium 1000 mg/kg 10 35 201 15 1 Hyperplasia Minimal Natural Death
Alimentary System Stomach, Forestomach Epithelium 1000 mg/kg 10 35 202 18 1 Hyperplasia Minimal Natural Death
Alimentary System Stomach, Forestomach Epithelium 1000 mg/kg 10 35 203 25 1 Hyperplasia Minimal Natural Death
Alimentary System Stomach, Forestomach Epithelium 1000 mg/kg 10 36 207 21 1 Hyperplasia Minimal Natural Death
Alimentary System Stomach, Forestomach Epithelium 1000 mg/kg 10 36 208 18 1 Hyperplasia Minimal Natural Death
Alimentary System Stomach, Forestomach 1000 mg/kg 10 36 210 6 1 Inflammation Minimal, Acute Dosing Accident
Cardiovascular System Heart Vehicle Control 10 26 158 29 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 500 mg/kg 10 33 191 29 1 Cardiomyopathy Minimal Terminal Sacrifice
Genital System Epididymis Duct 1000 mg/kg 10 35 201 15 1 Exfoliated Germ Cell Minimal Natural Death
Genital System Epididymis Duct 1000 mg/kg 10 35 202 18 1 Exfoliated Germ Cell Minimal Natural Death
Genital System Testes Germinal Epith 1000 mg/kg 10 36 207 21 1 Degeneration Minimal Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 36 210 6 1 Hypocellularity Mild Dosing Accident
Hematopoietic System Bone Marrow 1000 mg/kg 10 35 201 15 1 Hypocellularity Mild Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 35 202 18 1 Hypocellularity Mild Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 35 203 25 1 Hypocellularity Moderate Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 35 204 24 1 Hypocellularity Moderate Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 35 205 18 1 Hypocellularity Moderate Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 36 206 25 1 Hypocellularity Moderate Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 36 207 21 1 Hypocellularity Moderate Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 36 208 18 1 Hypocellularity Mild Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 36 209 17 1 Hypocellularity Moderate Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 35 201 15 1 Atrophy Moderate Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 35 203 25 1 Atrophy Moderate Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 36 206 25 1 Atrophy Moderate Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 36 207 21 1 Atrophy Marked Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 36 208 18 1 Atrophy Moderate Natural Death
Respiratory System Lung Alveolar Epith 500 mg/kg 10 34 196 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Alveolar Epith 1000 mg/kg 10 35 203 25 1 Hyperplasia Mild Natural Death
Respiratory System Lung Perivascular 1000 mg/kg 10 36 210 6 1 Inflammation Minimal, Acute Dosing Accident
Respiratory System Lung Vehicle Control 10 26 158 29 1 Erythrophagocytosis Minimal Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 34 196 29 1 Erythrophagocytosis Minimal Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 35 203 25 1 Fibrosis Mild Natural Death
Respiratory System Lung 1000 mg/kg 10 36 210 6 1 Hemorrhage Mild Dosing Accident
Respiratory System Lung 1000 mg/kg 10 35 203 25 1 Hemorrhage Mild Natural Death
Respiratory System Lung Vehicle Control 10 26 158 29 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 33 193 29 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 34 196 29 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 26 158 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 35 203 25 1 Inflammation Mild, Chronic Active Natural Death
Respiratory System Nose Olfactory Epi 125 mg/kg 10 29 173 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 29 175 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 30 176 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 31 181 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 31 182 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 31 184 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 31 185 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 32 186 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 32 187 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 32 188 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 191 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 192 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 193 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 194 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 195 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 34 196 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 34 197 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 34 198 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 34 200 29 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 210 6 1 Degeneration Mild Dosing Accident
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 201 15 1 Degeneration Mild Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 202 18 1 Degeneration Mild Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 203 25 1 Degeneration Mild Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 204 24 1 Degeneration Moderate Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 205 18 1 Degeneration Mild Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 206 25 1 Degeneration Moderate Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 207 21 1 Degeneration Moderate Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 209 17 1 Degeneration Mild Natural Death
Respiratory System Nose Olfactory Epi 125 mg/kg 10 29 175 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 30 176 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 31 181 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 31 182 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 31 185 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 32 187 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 32 188 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 191 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 192 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 193 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 194 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 195 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 34 196 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 34 197 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 34 198 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 34 200 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 210 6 1 Hyperplasia Mild Dosing Accident
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 201 15 1 Hyperplasia Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 206 25 1 Hyperplasia Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 207 21 1 Hyperplasia Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 209 17 1 Hyperplasia Mild Natural Death
Respiratory System Nose Olfactory Epi 250 mg/kg 10 31 184 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 32 188 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 33 194 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 34 200 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 210 6 1 Inflammation Moderate, Suppurative Dosing Accident
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 201 15 1 Inflammation Moderate, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 202 18 1 Inflammation Minimal, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 203 25 1 Inflammation Mild, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 204 24 1 Inflammation Marked, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 205 18 1 Inflammation Mild, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 206 25 1 Inflammation Moderate, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 207 21 1 Inflammation Moderate, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 209 17 1 Inflammation Minimal, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 210 6 1 Necrosis Mild Dosing Accident
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 202 18 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 203 25 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 204 24 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 35 205 18 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 207 21 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 36 209 17 1 Necrosis Moderate Natural Death
Special Senses System Harderian Gland Vehicle Control 10 25 153 29 1 Infiltration Cellular Mild, Mononuclear Cl Terminal Sacrifice
Urinary System Kidney Papilla 1000 mg/kg 10 35 201 15 1 Necrosis Mild Natural Death
Urinary System Kidney Vehicle Control 10 25 151 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 25 153 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 25 154 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 25 155 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 26 157 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 26 158 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 27 162 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 27 163 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 28 167 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 28 169 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 125 mg/kg 10 29 175 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 125 mg/kg 10 30 176 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 31 181 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 31 184 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 31 185 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 32 186 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 32 187 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 32 189 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 33 193 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 33 195 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 34 197 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 35 201 15 1 Nephropathy Minimal, Chronicprogr Natural Death
Urinary System Kidney 1000 mg/kg 10 36 206 25 1 Nephropathy Minimal, Chronicprogr Natural Death
Urinary System Kidney 1000 mg/kg 10 36 209 17 1 Nephropathy Minimal, Chronicprogr Natural Death