If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Perfluorooctanoic Acid
CASRN: ="335-67-1"
Study Number: C91070B
Exposure Route: GAVAGE
TDMS Number: 9107001
Sex: Female
Strain and Species: HSD Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus 100 mg/kg 10 112 670 29 1 Fibrosis Mild Terminal Sacrifice
Alimentary System Esophagus 100 mg/kg 10 112 670 29 1 Inflammation Minimal, Histiocytic Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 107 641 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 107 642 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 107 643 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 107 644 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 107 645 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 108 646 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 108 647 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 108 648 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 108 649 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 108 650 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 109 651 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 109 652 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 109 653 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 109 654 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 109 655 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 110 656 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 110 657 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 110 658 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 110 659 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 110 660 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 669 8 1 Cytoplasmic Alteration Minimal Natural Death
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 661 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 662 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 663 29 1 Cytoplasmic Alteration Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 664 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 665 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 666 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 667 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 668 29 1 Cytoplasmic Alteration Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 670 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 109 653 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 mg/kg 10 109 654 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 669 8 1 Hypertrophy Mild Natural Death
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 661 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 662 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 663 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 664 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 111 665 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 666 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 667 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 668 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 mg/kg 10 112 670 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver 12.5 mg/kg 10 106 636 29 1 Clear Cell Focus Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 101 614 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 6.25 mg/kg 10 104 627 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 12.5 mg/kg 10 105 632 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 25 mg/kg 10 108 649 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 50 mg/kg 10 109 655 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Pancreas Vehicle Control 10 101 612 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Alimentary System Stomach, Forestomach Mucosa 100 mg/kg 10 112 670 29 1 Hyperplasia Mild Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 100 mg/kg 10 112 669 8 1 Atrophy Moderate Natural Death
Endocrine System Thyroid Gland Follicular Cel 50 mg/kg 10 110 656 29 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 100 mg/kg 10 111 661 29 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 100 mg/kg 10 111 662 29 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 100 mg/kg 10 111 663 29 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 100 mg/kg 10 111 664 29 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 100 mg/kg 10 112 666 29 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 100 mg/kg 10 112 667 29 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 100 mg/kg 10 112 668 29 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 100 mg/kg 10 112 670 29 1 Hypertrophy Minimal Terminal Sacrifice
Genital System Uterus 12.5 mg/kg 1 105 635 29 1 Cyst Terminal Sacrifice
Hematopoietic System Bone Marrow 50 mg/kg 10 109 652 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 100 mg/kg 10 112 669 8 1 Hypocellularity Mild Natural Death
Hematopoietic System Lymph Node Mesenteric 100 mg/kg 10 112 669 8 1 Atrophy Mild Natural Death
Hematopoietic System Lymph Node Mesenteric 100 mg/kg 10 112 669 8 1 Infiltration Cellular Marked, Histiocyte Natural Death
Hematopoietic System Lymph Node Mesenteric, Lymphocyte 100 mg/kg 10 112 669 8 1 Apoptosis Moderate Natural Death
Hematopoietic System Spleen White Pulp 100 mg/kg 10 112 669 8 1 Atrophy Marked Natural Death
Hematopoietic System Thymus 100 mg/kg 10 112 669 8 1 Atrophy Marked Natural Death
Respiratory System Lung 100 mg/kg 10 111 665 29 1 Fibrosis Minimal, Focal Terminal Sacrifice
Respiratory System Lung 100 mg/kg 10 111 663 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Respiratory System Lung 100 mg/kg 10 111 665 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 mg/kg 10 108 646 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 mg/kg 10 108 650 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 109 651 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 109 653 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 109 654 29 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 656 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 657 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 658 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 659 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 660 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 112 669 8 1 Degeneration Moderate Natural Death
Respiratory System Nose Olfactory Epi 100 mg/kg 10 111 661 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 111 662 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 111 663 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 111 664 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 111 665 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 112 666 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 112 668 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 112 670 29 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 mg/kg 10 108 646 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 25 mg/kg 10 108 650 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 109 651 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 109 653 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 109 654 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 656 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 657 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 658 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 659 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 110 660 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 50 mg/kg 10 109 654 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 112 669 8 1 Inflammation Mild, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 100 mg/kg 10 111 661 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 111 662 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 111 663 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 111 665 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 100 mg/kg 10 112 670 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose Respirat Epith 12.5 mg/kg 10 105 631 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 12.5 mg/kg 10 105 632 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 12.5 mg/kg 10 106 637 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 12.5 mg/kg 10 106 638 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 mg/kg 10 110 657 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 mg/kg 10 110 658 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 mg/kg 10 110 660 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 661 29 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 662 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 663 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 664 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 665 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 112 666 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 112 668 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 112 670 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 12.5 mg/kg 10 105 631 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 12.5 mg/kg 10 105 632 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 12.5 mg/kg 10 106 637 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 12.5 mg/kg 10 106 638 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 25 mg/kg 10 108 649 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 mg/kg 10 109 652 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 mg/kg 10 109 653 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 mg/kg 10 110 657 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 mg/kg 10 110 658 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 mg/kg 10 110 659 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 50 mg/kg 10 110 660 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 112 669 8 1 Inflammation Minimal, Chronic Active Natural Death
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 661 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 662 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 663 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 664 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 111 665 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 112 666 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 112 668 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 100 mg/kg 10 112 670 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Urinary System Kidney Renal Tubule 100 mg/kg 10 112 669 8 1 Necrosis Mild Natural Death
Urinary System Kidney Renal Tubule 100 mg/kg 10 112 669 8 1 Regeneration Minimal Natural Death
Urinary System Kidney Vehicle Control 10 101 611 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 102 616 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 102 617 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 102 618 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 102 620 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 6.25 mg/kg 10 103 621 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 6.25 mg/kg 10 103 623 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 6.25 mg/kg 10 104 627 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 12.5 mg/kg 10 105 632 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 12.5 mg/kg 10 105 635 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 25 mg/kg 10 107 641 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 50 mg/kg 10 109 653 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 50 mg/kg 10 109 655 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 50 mg/kg 10 110 656 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 50 mg/kg 10 110 657 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 50 mg/kg 10 110 658 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 100 mg/kg 10 111 662 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 100 mg/kg 10 112 666 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 100 mg/kg 10 112 668 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 100 mg/kg 10 112 670 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice