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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Perfluorohexanoic acid (PFHXA)
CASRN: ="307-24-4"
Study Number: C20613
Exposure Route: GAVAGE
TDMS Number: 2061301
Sex: Female
Strain and Species: HSD Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 111 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 112 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 113 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 114 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 115 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 24 116 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 24 117 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 24 118 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 24 120 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 111 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 112 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 113 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 114 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 23 115 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 24 116 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 24 117 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 24 118 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 24 120 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 14 70 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 62.6 mg/kg 10 15 71 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 62.6 mg/kg 10 16 77 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 19 95 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 23 111 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Stomach, Forestomach Epithelium 1000 mg/kg 10 23 115 29 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach, Forestomach Epithelium 1000 mg/kg 10 24 120 29 1 Hyperplasia Mild Terminal Sacrifice
Genital System Uterus Bilateral Vehicle Control 10 14 68 29 1 Dilation Moderate Terminal Sacrifice
Genital System Uterus Bilateral 62.6 mg/kg 2 15 75 29 1 Dilation Moderate Terminal Sacrifice
Genital System Uterus Bilateral 62.6 mg/kg 2 16 78 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral 125 mg/kg 1 17 82 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral 250 mg/kg 2 20 96 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral 250 mg/kg 2 20 98 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral 500 mg/kg 3 21 105 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral 500 mg/kg 3 22 107 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral 500 mg/kg 3 22 109 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral 1000 mg/kg 10 23 114 29 1 Dilation Moderate Terminal Sacrifice
Hematopoietic System Spleen 500 mg/kg 10 21 102 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 500 mg/kg 10 21 103 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 23 111 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 23 112 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 23 113 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 23 115 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 24 116 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 24 117 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 24 118 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 24 119 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 24 120 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Respiratory System Lung Bronchiole 1000 mg/kg 10 23 113 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole 1000 mg/kg 10 23 113 29 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 23 113 29 1 Fibrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 62.6 mg/kg 10 15 75 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 17 82 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 17 83 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 18 87 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 19 91 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 19 92 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 19 93 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 19 94 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 19 95 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 20 100 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 20 97 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 20 98 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 20 99 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 21 101 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 21 102 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 21 104 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 21 105 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 106 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 107 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 108 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 109 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 110 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 23 112 29 1 Degeneration Marked Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 23 114 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 23 115 29 1 Degeneration Marked Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 24 117 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 24 119 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 24 120 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 17 82 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 17 83 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 18 87 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 19 91 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 19 93 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 20 97 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 20 99 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 21 101 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 21 104 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 21 105 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 106 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 108 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 109 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 110 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 23 114 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 23 115 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 24 119 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 19 94 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 21 101 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 106 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 108 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 109 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 22 110 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 23 111 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 23 112 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 23 114 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 23 115 29 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 24 116 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 24 117 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 24 119 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 24 120 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 24 120 29 1 Cyst Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 13 65 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 14 68 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 15 71 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 15 75 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 16 77 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 16 80 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 125 mg/kg 10 17 84 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 125 mg/kg 10 18 86 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 125 mg/kg 10 18 87 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 125 mg/kg 10 18 88 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 20 97 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 21 101 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 21 104 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 22 109 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 23 111 29 1 Nephropathy Mild, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 23 113 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 23 114 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 23 115 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 24 116 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 24 118 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 24 119 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 24 120 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice