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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Perfluorohexanoic acid (PFHXA)
CASRN: ="307-24-4"
Study Number: C20613
Exposure Route: GAVAGE
TDMS Number: 2061301
Sex: Male
Strain and Species: HSD Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus 1000 mg/kg 10 12 59 29 1 Inflammation Mild, Focal, Suppurative Terminal Sacrifice
Alimentary System Esophagus 1000 mg/kg 10 12 59 29 1 Ulcer Moderate, Focal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 9 42 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 9 45 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 51 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 52 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 53 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 54 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 55 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 56 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 57 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 58 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 59 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 60 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 10 46 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 10 47 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 10 48 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 10 49 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 10 50 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 9 41 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 9 42 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 9 43 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 9 45 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 51 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 52 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 53 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 54 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 11 55 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 56 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 57 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 58 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 59 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 60 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 12 59 29 1 Necrosis Moderate Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 42 29 1 Clear Cell Focus Terminal Sacrifice
Alimentary System Liver 125 mg/kg 10 5 25 29 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 10 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 6 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 7 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 62.6 mg/kg 10 4 20 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 7 35 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 8 37 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 47 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 48 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 10 49 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 43 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 500 mg/kg 10 9 44 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Stomach, Forestomach Epithelium 1000 mg/kg 10 12 59 29 1 Ulcer Mild Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 4 29 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 1 29 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Genital System Epididymis Duct 1000 mg/kg 10 12 59 29 1 Exfoliated Germ Cell Minimal Terminal Sacrifice
Genital System Testes Germinal Epith 125 mg/kg 10 6 27 29 1 Atrophy Mild Terminal Sacrifice
Genital System Testes Interstit Cell 1000 mg/kg 10 12 60 29 1 Atrophy Minimal Terminal Sacrifice
Genital System Testes Seminif Tub Vehicle Control 10 2 8 29 1 Spermatid Retention Minimal Terminal Sacrifice
Genital System Testes Seminif Tub 1000 mg/kg 10 11 55 29 1 Spermatid Retention Mild Terminal Sacrifice
Genital System Testes Seminif Tub 1000 mg/kg 10 12 60 29 1 Spermatid Retention Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 62.6 mg/kg 1 3 13 29 1 Inflammation Marked, Granulomatous Terminal Sacrifice
Hematopoietic System Spleen 500 mg/kg 10 10 46 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 500 mg/kg 10 10 48 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 500 mg/kg 10 10 49 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 500 mg/kg 10 10 50 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 500 mg/kg 10 9 42 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 500 mg/kg 10 9 44 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 11 51 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 11 52 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 11 53 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 11 54 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 11 55 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 12 56 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 12 57 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 12 58 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 12 59 29 1 Increased Extramedullary Hematopoiesis Minimal Terminal Sacrifice
Hematopoietic System Spleen 1000 mg/kg 10 12 60 29 1 Increased Extramedullary Hematopoiesis Mild Terminal Sacrifice
Respiratory System Lung Bronchiole 1000 mg/kg 10 12 60 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Lung Bronchiole 1000 mg/kg 10 12 60 29 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 12 60 29 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 5 21 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 7 31 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 7 32 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 7 33 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 8 36 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 8 38 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 8 40 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 46 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 49 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 50 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 9 42 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 9 43 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 9 45 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 11 51 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 11 52 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 11 53 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 12 56 29 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 12 59 29 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 12 60 29 1 Degeneration Marked Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 7 31 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 7 32 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 7 33 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 8 36 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 8 38 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 8 40 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 46 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 48 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 49 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 50 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 9 43 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 11 51 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 11 52 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 11 53 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 12 56 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 12 59 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 12 60 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 46 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 49 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 10 50 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 11 51 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 11 52 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 11 53 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 12 56 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 12 59 29 1 Inflammation Mild, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 12 60 29 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 9 42 29 1 Cyst Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 5 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 6 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 9 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 3 11 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 3 13 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 3 14 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 3 15 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 4 17 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 4 18 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 4 19 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 4 20 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 125 mg/kg 10 5 22 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 125 mg/kg 10 5 23 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 125 mg/kg 10 5 25 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 7 31 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 7 32 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 7 34 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 7 35 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 8 36 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 8 37 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 8 38 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 8 39 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 9 43 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 9 45 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 11 51 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 11 53 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 11 55 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 56 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 57 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 12 59 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice