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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Wyeth 14,643 (WY)
CASRN: ="50892-23-4"
Study Number: C91069
Exposure Route: GAVAGE
TDMS Number: 9106901
Sex: Female
Strain and Species: HSD Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus Muscularis 25 mg/kg 10 87 522 29 1 Degeneration Minimal Terminal Sacrifice
Alimentary System Esophagus Muscularis 25 mg/kg 10 87 522 29 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Esophagus 25 mg/kg 10 88 526 29 1 Inflammation Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 6.25 mg/kg 10 83 503 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 6.25 mg/kg 10 83 505 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 6.25 mg/kg 10 84 506 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 6.25 mg/kg 10 84 507 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 6.25 mg/kg 10 84 508 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 6.25 mg/kg 10 84 509 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 6.25 mg/kg 10 84 510 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 85 511 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 85 512 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 85 513 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 85 514 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 85 515 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 86 516 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 86 517 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 86 518 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 86 519 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 86 520 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 521 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 522 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 523 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 524 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 525 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 88 526 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 88 527 29 1 Cytoplasmic Alteration Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 88 528 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 88 529 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 88 530 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 86 518 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 12.5 mg/kg 10 86 520 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 521 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 522 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 523 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 524 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 87 525 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 88 526 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 88 527 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 25 mg/kg 10 88 528 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 81 494 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 12.5 mg/kg 10 85 514 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Alimentary System Liver 12.5 mg/kg 10 85 514 29 1 Necrosis Mild Terminal Sacrifice
Alimentary System Liver 25 mg/kg 10 88 526 29 1 Necrosis Mild, Focal Terminal Sacrifice
Alimentary System Pancreas Vehicle Control 10 81 492 29 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Pancreas 12.5 mg/kg 10 86 516 29 1 Inflammation Minimal, Chronic Terminal Sacrifice
Cardiovascular System Heart 25 mg/kg 10 88 530 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Genital System Ovary 6.25 mg/kg 10 84 509 29 1 Cyst Terminal Sacrifice
Genital System Ovary 6.25 mg/kg 10 84 507 29 1 Hematocyst Terminal Sacrifice
Genital System Uterus 25 mg/kg 10 87 523 29 1 Cyst Terminal Sacrifice
Genital System Uterus 25 mg/kg 10 87 525 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus 25 mg/kg 10 88 526 29 1 Dilation Mild Terminal Sacrifice
Respiratory System Lung Alveolar Epith 25 mg/kg 10 88 529 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Lung Alveolar Epith Vehicle Control 10 82 499 29 1 Hypertrophy Minimal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 81 494 29 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 82 499 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 81 492 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 81 494 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 81 495 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 82 496 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 82 498 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 6.25 mg/kg 10 83 501 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 6.25 mg/kg 10 83 502 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 6.25 mg/kg 10 84 507 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 12.5 mg/kg 10 85 514 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 12.5 mg/kg 10 86 516 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 12.5 mg/kg 10 86 517 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 25 mg/kg 10 87 522 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 25 mg/kg 10 87 524 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 25 mg/kg 10 87 525 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 25 mg/kg 10 88 526 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 25 mg/kg 10 88 529 29 1 Nephropathy Mild, Chronicprogr Terminal Sacrifice
Urinary System Kidney 25 mg/kg 10 88 530 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice