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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Perfluorobutane sulfonate (PFBS)
CASRN: ="375-73-5"
Study Number: C07040
Exposure Route: GAVAGE
TDMS Number: 0704001
Sex: Female
Strain and Species: HSD Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus 500 mg/kg 10 46 257 29 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Esophagus 1000 mg/kg 10 47 261 27 1 Inflammation Mild, Chronic Natural Death
Alimentary System Esophagus 1000 mg/kg 10 47 262 22 1 Inflammation Minimal, Chronic Natural Death
Alimentary System Esophagus 1000 mg/kg 10 47 265 29 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Bile Duct 250 mg/kg 10 43 243 29 1 Cyst Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 45 251 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 45 252 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 45 253 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 45 254 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 256 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 257 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 258 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 259 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 260 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 261 27 1 Cytoplasmic Alteration Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 262 22 1 Cytoplasmic Alteration Moderate Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 263 20 1 Cytoplasmic Alteration Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 266 22 1 Cytoplasmic Alteration Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 267 16 1 Cytoplasmic Alteration Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 268 23 1 Cytoplasmic Alteration Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 269 21 1 Cytoplasmic Alteration Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 270 27 1 Cytoplasmic Alteration Marked Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 264 29 1 Cytoplasmic Alteration Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 265 29 1 Cytoplasmic Alteration Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 45 251 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 45 253 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 45 254 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 256 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 257 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 258 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 259 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 mg/kg 10 46 260 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 261 27 1 Hypertrophy Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 262 22 1 Hypertrophy Moderate Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 263 20 1 Hypertrophy Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 266 22 1 Hypertrophy Mild Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 267 16 1 Hypertrophy Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 268 23 1 Hypertrophy Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 269 21 1 Hypertrophy Minimal Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 48 270 27 1 Hypertrophy Marked Natural Death
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 264 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1000 mg/kg 10 47 265 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 37 213 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 250 mg/kg 10 44 246 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 10 48 268 23 1 Necrosis Minimal Natural Death
Alimentary System Liver 1000 mg/kg 10 48 270 27 1 Necrosis Minimal Natural Death
Alimentary System Liver 1000 mg/kg 10 47 265 29 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Stomach, Forestomach 500 mg/kg 10 46 257 29 1 Ulcer Mild Terminal Sacrifice
Cardiovascular System Heart Epicardium 1000 mg/kg 10 47 265 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Cardiovascular System Heart Myocardium 1000 mg/kg 10 47 265 29 1 Necrosis Minimal Terminal Sacrifice
Cardiovascular System Heart 1000 mg/kg 10 48 266 22 1 Cardiomyopathy Minimal Natural Death
Genital System Uterus Bilateral 125 mg/kg 1 42 239 29 1 Dilation Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 1000 mg/kg 10 47 262 22 1 Hypocellularity Mild Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 47 263 20 1 Hypocellularity Moderate Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 48 266 22 1 Hypocellularity Moderate Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 48 267 16 1 Hypocellularity Marked Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 48 268 23 1 Hypocellularity Moderate Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 48 269 21 1 Hypocellularity Mild Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 48 270 27 1 Hypocellularity Marked Natural Death
Hematopoietic System Bone Marrow 1000 mg/kg 10 47 264 29 1 Hypocellularity Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 1000 mg/kg 10 47 265 29 1 Hypocellularity Moderate Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 1000 mg/kg 10 48 269 21 1 Necrosis Minimal, Lymphoid Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 47 262 22 1 Atrophy Mild Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 47 263 20 1 Atrophy Moderate Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 48 267 16 1 Atrophy Marked Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 48 268 23 1 Atrophy Moderate Natural Death
Hematopoietic System Thymus 1000 mg/kg 10 47 265 29 1 Atrophy Moderate Terminal Sacrifice
Hematopoietic System Thymus 1000 mg/kg 10 47 265 29 1 Necrosis Mild, Lymphoid Terminal Sacrifice
Integumentary System Skin 250 mg/kg 1 44 249 25 1 Hemorrhage Moderate Natural Death
Respiratory System Lung 500 mg/kg 10 45 255 21 1 Erythrophagocytosis Minimal Natural Death
Respiratory System Lung 1000 mg/kg 10 47 265 29 1 Erythrophagocytosis Minimal Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 47 265 29 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung 500 mg/kg 10 45 255 21 1 Inflammation Minimal, Chronic Active Natural Death
Respiratory System Lung 500 mg/kg 10 45 251 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 10 47 265 29 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 41 233 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 41 234 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 42 239 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 42 240 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 44 249 25 1 Degeneration Minimal Natural Death
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 241 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 242 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 243 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 244 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 245 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 44 246 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 44 247 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 44 250 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 255 21 1 Degeneration Mild Natural Death
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 251 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 252 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 253 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 256 29 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 257 29 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 258 29 1 Degeneration Marked Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 259 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 260 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 262 22 1 Degeneration Mild Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 263 20 1 Degeneration Mild Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 266 22 1 Degeneration Marked Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 268 23 1 Degeneration Mild Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 270 27 1 Degeneration Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 264 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 265 29 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 44 249 25 1 Hyperplasia Minimal Natural Death
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 241 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 242 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 243 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 244 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 43 245 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 44 246 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 44 247 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 255 21 1 Hyperplasia Minimal Natural Death
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 251 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 252 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 253 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 256 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 257 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 258 29 1 Hyperplasia Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 259 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 500 mg/kg 10 46 260 29 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 268 23 1 Hyperplasia Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 269 21 1 Hyperplasia Mild Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 270 27 1 Hyperplasia Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 265 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 125 mg/kg 10 41 233 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 250 mg/kg 10 44 249 25 1 Inflammation Minimal, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 255 21 1 Inflammation Mild, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 500 mg/kg 10 45 253 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 262 22 1 Inflammation Moderate, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 263 20 1 Inflammation Mild, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 266 22 1 Inflammation Moderate, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 267 16 1 Inflammation Moderate, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 268 23 1 Inflammation Moderate, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 269 21 1 Inflammation Moderate, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 270 27 1 Inflammation Mild, Suppurative Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 265 29 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 262 22 1 Necrosis Mild Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 263 20 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 267 16 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 268 23 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 48 269 21 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 1000 mg/kg 10 47 265 29 1 Necrosis Minimal Terminal Sacrifice
Urinary System Kidney Papilla 1000 mg/kg 10 47 263 20 1 Necrosis Mild Natural Death
Urinary System Kidney Papilla 1000 mg/kg 10 48 267 16 1 Necrosis Mild Natural Death
Urinary System Kidney Papilla 1000 mg/kg 10 48 268 23 1 Necrosis Minimal Natural Death
Urinary System Kidney Papilla 1000 mg/kg 10 48 269 21 1 Necrosis Minimal Natural Death
Urinary System Kidney 62.6 mg/kg 10 39 225 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 40 226 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 40 228 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 62.6 mg/kg 10 40 230 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 44 249 25 1 Nephropathy Minimal, Chronicprogr Natural Death
Urinary System Kidney 250 mg/kg 10 43 245 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 250 mg/kg 10 44 247 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 500 mg/kg 10 46 256 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1000 mg/kg 10 47 263 20 1 Nephropathy Minimal, Chronicprogr Natural Death
Urinary System Kidney 1000 mg/kg 10 48 267 16 1 Nephropathy Minimal, Chronicprogr Natural Death
Urinary System Kidney 1000 mg/kg 10 48 268 23 1 Nephropathy Minimal, Chronicprogr Natural Death