Alimentary System |
Liver |
|
Vehicle Control |
10 |
61 |
61 |
93 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
61 |
62 |
93 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
62 |
69 |
93 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
10 |
67 |
93 |
93 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
10 |
67 |
94 |
93 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
10 |
68 |
97 |
93 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
10 |
69 |
101 |
65 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
50 MG/KG |
10 |
69 |
103 |
72 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
50 MG/KG |
10 |
70 |
106 |
83 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
50 MG/KG |
10 |
70 |
110 |
75 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
75 MG/KG |
10 |
72 |
118 |
51 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
75 MG/KG |
10 |
72 |
120 |
49 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
75 MG/KG |
10 |
72 |
119 |
42 |
1 |
Hepatodiaphragmatic Nodule |
|
Natural Death |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
10 |
61 |
63 |
93 |
1 |
Atrophy |
Mild, Focal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
10 |
61 |
62 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
10 |
62 |
67 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
10 |
62 |
67 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
50 MG/KG |
10 |
70 |
106 |
83 |
1 |
Accessory Adrenal Cortical Nodule |
Mild |
Natural Death |
Genital System |
Uterus |
|
12.5 MG/KG |
10 |
65 |
84 |
93 |
1 |
Dilatation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
10 |
62 |
66 |
93 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
25 MG/KG |
10 |
68 |
100 |
93 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
6.25 MG/KG |
1 |
63 |
71 |
93 |
1 |
Hyperplasia |
Minimal, Focal, Lymphoid |
Terminal Sacrifice |
Nervous System |
Brain |
|
50 MG/KG |
10 |
69 |
104 |
93 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
10 |
69 |
103 |
72 |
1 |
Congestion |
Mild |
Natural Death |
Respiratory System |
Lung |
|
50 MG/KG |
10 |
70 |
106 |
83 |
1 |
Congestion |
Minimal |
Natural Death |
Respiratory System |
Lung |
|
75 MG/KG |
10 |
71 |
111 |
51 |
1 |
Congestion |
Mild |
Natural Death |
Respiratory System |
Lung |
|
75 MG/KG |
10 |
71 |
112 |
49 |
1 |
Congestion |
Minimal |
Natural Death |
Respiratory System |
Lung |
|
75 MG/KG |
10 |
72 |
116 |
56 |
1 |
Congestion |
Mild |
Natural Death |
Respiratory System |
Lung |
|
50 MG/KG |
10 |
69 |
101 |
65 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Respiratory System |
Lung |
|
50 MG/KG |
10 |
69 |
105 |
75 |
1 |
Hemorrhage |
Minimal |
Natural Death |
Respiratory System |
Lung |
|
25 MG/KG |
10 |
67 |
92 |
93 |
1 |
Infiltration Cellular |
Mild, Focal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
25 MG/KG |
10 |
67 |
92 |
93 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
62 |
67 |
93 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
61 |
61 |
93 |
1 |
Casts Protein |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
61 |
63 |
93 |
1 |
Casts Protein |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
62 |
68 |
93 |
1 |
Casts Protein |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
61 |
65 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
10 |
70 |
106 |
83 |
1 |
Nephropathy |
Minimal |
Natural Death |