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DART-02: Developmental and Reproductive Toxicity

Growth and Clinical Finding Tables (I), Pathology Tables (PA), Developmental and Reproductive Tables (R) from NTP Developmental and Reproductive Toxicity Studies

West Virginia Chemical Spill

Supporting data files and reports are from studies conducted by NTP on chemicals associated with the Elk River spill in West Virginia. These data were used as the basis for the updates that NTP released in 2014-2016 ( The data and results for this study have been peer reviewed by an external expert.

If you need help accessing these data, please contact

Summary data PDF files originally released on October 2, 2015, were replaced on December 9, 2015, with versions with new formats. There are no changes to the data; the new files have a different format for improved readability. The Chemical Methods file was updated on July 8, 2016. The Materials and Methods files were updated on July 12, 2016.

Updated graph (I03) for higher quality image. Fetal summary (R10 and R11) and gross pathology (PA46) data tables were updated to reflect new statistics (October 15, 2018)

Note: The study data are being disseminated prior to external peer review under applicable information quality guidelines and do not represent and should not be construed to represent any final NTP determination or policy.

DART-02: 4-Methylcyclohexanemethanol (MCHM)

Prenatal Developmental Toxicity Dose Range Finding Study - Rats

Prenatal Developmental Toxicity Study- Rats