Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Project 4: Epidemiology, Biomarkers and Exposure Assessment of Metals

Parent Title:
Sources and Protracted Effects of Early Life Exposure to Arsenic and Mercury
Grant Number:
Principal Investigator:
Karagas, Margaret Rita (Contact); Chen, Celia
Dartmouth College
Most Recent Award Year:
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Adulthood (mother)
Assessment: Adulthood (mother)
Metals: Arsenic; Lead; Manganese; Mercury/methylmercury; Zinc
Nutrition/Diet/Supplements: Selenium
Health Outcomes:
Birth Outcomes: Birthweight; Gestational age
Cardiovascular Outcomes: Maternal blood pressure
Metabolic Outcomes: Maternal glucose metabolism
Other: Maternal-infant inflammatory markers
Biological Sample:
Toenails (mother, child); Hair (mother); Urine (mother, child)
Environmental Sample:
Drinking water sample
Genes or Other DNA Products Studied:
Arsenic metabolism genes (e.g., GSTO1, GSTO2, AS3T, PNP); Polymorphisms in one carbon metabolism genes

Related NIEHS-Funded Study Populations

The New Hampshire Birth Cohort Study

Principal Investigator:
Dartmouth College
New Hampshire; Vermont
Number of Participants::
2,000+ Mother-infant pairs
Brief Description::
This is a prospective pregnancy cohort study of mothers who use private wells for household water in New Hampshire designed to evaluate maternal/child health impacts of arsenic and other contaminants. The study has recruited over 2,500 mother-infant pairs (over 4,000 individuals) since 2009.
to Top