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Your Environment. Your Health.

Project 4: Epidemiology, Biomarkers and Exposure Assessment of Metals

Parent Title:
Sources and Protracted Effects of Early Life Exposure to Arsenic and Mercury
Grant Number:
Principal Investigator:
Karagas, Margaret Rita (Contact); Chen, Celia
Institution:
Dartmouth College
Most Recent Award Year:
2008
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Adulthood (mother)
Assessment: Adulthood (mother)
Exposures:
Metals: Arsenic; Lead; Manganese; Mercury/methylmercury; Zinc
Mixtures:
Nutrition/Diet/Supplements: Selenium
Health Outcomes:
Birth Outcomes: Birthweight; Gestational age
Cardiovascular Outcomes: Maternal blood pressure
Metabolic Outcomes: Maternal glucose metabolism
Other: Maternal-infant inflammatory markers
Biological Sample:
Toenails (mother, child); Hair (mother); Urine (mother, child)
Environmental Sample:
Drinking water sample
Genes or Other DNA Products Studied:
Arsenic metabolism genes (e.g., GSTO1, GSTO2, AS3T, PNP); Polymorphisms in one carbon metabolism genes
Abstract:

Related NIEHS-Funded Study Populations

The New Hampshire Birth Cohort Study

Principal Investigator:
Institution:
Dartmouth College
Location:
New Hampshire; Vermont
Number of Participants::
2,000+ Mother-infant pairs
Brief Description::
This is a prospective pregnancy cohort study of mothers who use private wells for household water in New Hampshire designed to evaluate maternal/child health impacts of arsenic and other contaminants. The study has recruited over 2,500 mother-infant pairs (over 4,000 individuals) since 2009.
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