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Your Environment. Your Health.

Fetal Lead Exposure, Genes, and Neurodevelopment

Grant Number:
Principal Investigator:
Hu, Howard
Institution:
University of Michigan
Most Recent Award Year:
2006
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Youth (1-18 years, specifically up to 2 years of age); Adulthood (mother)
Assessment: Youth (1-18 years, specifically 2-15 years of age)
Exposures:
Metals: Lead
Health Outcomes:
Neurological/Cognitive Outcomes: Attention deficit hyperactivity disorder (ADHD); Neurobehavioral outcomes; Aggression
Biological Sample:
Plasma (mother, child)
Other Participant Data:
Bayley Scales of Mental Development and Cambridge Automated Neuropsychological Test Battery to measure cognition and behavior; Pre-pulse inhibition tests; School performance; Measures of cholesterol metabolism in mother and child
Genes or Other DNA Products Studied:
Polymorphic gene variants of cholesterol metabolism (APOE, lipoprotein E2 receptors, lipoprotein lipase and CYP46)
Abstract:

Related NIEHS-Funded Study Populations

Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT)

Principal Investigator:
Hu, Howard; Peterson, Karen; Hernandez-Avila, Mauricio; Tellez-Rojo, Martha Maria | Study Population Page Study Population c49
Institution:
University of Michigan
Location:
Mexico City, Mexico
Number of Participants::
1,653
Brief Description::
This is a group of three sequentially-enrolled, on-going, epidemiologic birth cohort studies in Mexico City with an original aim to investigate the impact of lead on child development. The research aims have since expanded to include a wide range health outcomes and environmental, nutritional, behavioral, genetic, and epigenetic risk factors. More than 1,600 mother-child pairs enrolled in the study beginning in 1994, some of whom have been followed for over two decades.
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