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Early Life Exposure to Metal Mixtures and Neuroimaging of Internalizing Behaviors in Childhood

Grant Number:
Principal Investigator:
Horton, Megan K
Institution:
Icahn School of Medicine at Mount Sinai
Most Recent Award Year:
2018
Lifestage of Participants:
Exposure: Prenatal; Infant (0-1 year); Youth (1-18 years)
Assessment: Youth (1-18 years, specifically 10-11 years of age)
Exposures:
Metals: Lead; Manganese; Zinc
Mixtures:
Health Outcomes:
Mental Health Outcomes: Internalizing behaviors (depression, anxiety)
Neurological/Cognitive Outcomes: Structural and functional changes in the brain
Biological Sample:
Teeth
Other Participant Data:
Validated self and parental reports of anxiety and depression; MRI to asses structural and functional changes in the brain
Abstract:

Related NIEHS-Funded Study Populations

Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT)

Principal Investigator:
Hu, Howard; Peterson, Karen; Hernandez-Avila, Mauricio; Tellez-Rojo, Martha Maria | Study Population Page Study Population c49
Institution:
University of Michigan
Location:
Mexico City, Mexico
Number of Participants::
1,653
Brief Description::
This is a group of three sequentially-enrolled, on-going, epidemiologic birth cohort studies in Mexico City with an original aim to investigate the impact of lead on child development. The research aims have since expanded to include a wide range health outcomes and environmental, nutritional, behavioral, genetic, and epigenetic risk factors. More than 1,600 mother-child pairs enrolled in the study beginning in 1994, some of whom have been followed for over two decades.
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